2026 ICD-10-CM Diagnosis Code D72.18Eosinophilia in diseases classified elsewhere

ICD-10-CM Codes›D50–D89›D70-D77›D72

ICD-10-CM D72.18
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D72.18 is a billable ICD-10-CM diagnosis code for eosinophilia in diseases classified elsewhere. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. The code is a manifestation code that cannot be reported as the principal diagnosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diseases of white blood cells.

Code Identity

ICD-10-CM Code
D72.18
Billable Status
Yes — Valid for Submission
Code Describes
Eosinophilia in diseases classified elsewhere
Short Description
Eosinophilia in diseases classified elsewhere
Same as the full description in the CMS dataset.
Parent Code
D72.1
Eosinophilia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD70-D77Other disorders of blood and blood-forming organs
CategoryD72Other disorders of white blood cells
This CodeD72.18Eosinophilia in diseases classified elsewhere

Code EditsBilling

Medicare Code Editor checks that affect claim validity for D72.18.

Manifestation diagnoses
Manifestation codes describe the manifestation of an underlying disease, not the disease itself, and therefore should not be used as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Aggressive lymphadenopathic mastocytosis with eosinophilia
  • Disorder of eosinophil
  • Disseminated eosinophilic collagen disease
  • Eosinophilia due to infectious disease
  • Episodic angioedema with eosinophilia
  • Episodic eosinophilia
  • Hereditary eosinophilia
  • Malignant mastocytosis
  • Omenn syndrome
  • Systemic mast cell disease

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Code First

  • underlying disease, such as:
  • chronic myelomonocytic leukemia C93.1

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Eosinophilia(allergic) (idiopathic) (secondary)
      • in disease classified elsewhere

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD007
Diseases of white blood cells
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • Omenn Syndrome

    a genetically heterogenous autosomal recessive severe combined immunodeficiency syndrome. caused by mutation(s) in the rag-1, rag-2, and dclre1c genes. it is characterized by the presence of alopecia, erythroderma, desquamation, lymphadenopathy, and chronic diarrhea.

  • Severe Combined Immunodeficiency due to RAG Deficiency with Omenn Syndrome|SCID, T-B-NK+ (RAG mutation) without Omenn Syndrome

    t-cell negative (t-), b-cell negative (b-) severe combined immunodeficiency (scid) caused by missense mutation(s) in the rag1 and/or rag2 genes, from which proteins encoded for by these gene(s) retain partial biologic activity that result in a less severe form of classical t-b-scid, along with clinical features of omenn syndrome.

  • Severe Combined Immunodeficiency due to RAG Deficiency without Omenn Syndrome|SCID, T-B-NK+ (RAG mutation) without Omenn Syndrome

    a rare severe combined immunodeficiency disorder caused by null mutations in recombination activating gene rag1 or rag2. phenotypically, it is toward the more severe end of the clinical spectrum due to complete arrest of t and b-cell development, without the clinical features of omenn syndrome.

Patient EducationClinical

Eosinophilic Disorders

Eosinophils are a type of white blood cell. They help fight off infections and play a role in your body's immune response. They can also build up and cause inflammation.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code History & ChangesHistory

Replacement D72.18 replaces the following previously assigned code(s):

  • D72.1 - Eosinophilia
FY 2021AddedAdded to the ICD-10-CM code setEffective October 1, 2020.
FY 2022–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D72.18Overview

Is D72.18 (Eosinophilia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report eosinophilia in diseases classified elsewhere on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D72.18 group to?

On inpatient claims, eosinophilia in diseases classified elsewhere maps to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.

Can D72.18 be a principal diagnosis?

No. This is a manifestation code: eosinophilia in diseases classified elsewhere describes the manifestation of an underlying disease rather than the disease itself, so the underlying condition is sequenced first.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.