2026 ICD-10-CM Diagnosis Code D68.61Antiphospholipid syndrome
ICD-10-CM Codes›D50–D89›D65-D69›D68
- Billable — Valid for Submission
- Chronic Condition
D68.61 is a billable ICD-10-CM diagnosis code for antiphospholipid syndrome. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Coagulation and hemorrhagic disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Antiphospholipid syndrome
- Antiphospholipid syndrome in pregnancy
- Catastrophic antiphospholipid syndrome
- Chorea due to antiphospholipid syndrome
- Chorea due to immunological disorder
- Myelitis due to anti-phospholipid syndrome
- Neonatal antiphospholipid syndrome
- Primary antiphospholipid syndrome
- Primary antiphospholipid syndrome with multisystem involvement
- Secondary antiphospholipid syndrome
- Secondary antiphospholipid syndrome with multisystem involvement
- Thrombophilia associated with pregnancy
- White matter disease due to anti-phospholipid syndrome
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Anticardiolipin syndrome
- Antiphospholipid antibody syndrome
Type 1 Excludes
- anti-phospholipid antibody, finding without diagnosis R76.0
Type 2 Excludes
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Antibody
- anticardiolipin - R76.0
- with
- hypercoagulable state - D68.61
- antiphosphatidylglycerol - R76.0
- with
- hypercoagulable state - D68.61
- antiphosphatidylinositol - R76.0
- with
- hypercoagulable state - D68.61
- antiphosphatidylserine - R76.0
- with
- hypercoagulable state - D68.61
- with
- hypercoagulable state - D68.61
- Anticardiolipin syndrome - D68.61
- Syndrome - See Also: Disease;
- anticardiolipin (-antibody) - D68.61
- antiphospholipid (-antibody) - D68.61
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Antibody
- anticardiolipin
- with
- hypercoagulable state
- Antibody
- antiphosphatidylglycerol
- with
- hypercoagulable state
- Antibody
- antiphosphatidylinositol
- with
- hypercoagulable state
- Antibody
- antiphosphatidylserine
- with
- hypercoagulable state
- Antibody
- antiphospholipid
- with
- hypercoagulable state
- Anticardiolipin syndrome
- Antiphospholipid
- antibody
- syndrome
- Syndrome
- anticardiolipin (-antibody)
- Syndrome
- antiphospholipid (-antibody)
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Antiphospholipid Syndrome
the presence of antibodies directed against phospholipids (antibodies, antiphospholipid). the condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. in pregnancy it can cause abortion. of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (antibodies, anticardiolipin). present also are high levels of lupus anticoagulant (lupus coagulation inhibitor).
Patient EducationClinical
Bleeding Disorders
Normally, if you get hurt, your body forms a blood clot to stop the bleeding. For blood to clot, your body needs cells called platelets and proteins known as clotting factors. If you have a bleeding disorder, you either do not have enough platelets or clotting factors or they don't work the way they should.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D68.61 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D68.61Overview
Is D68.61 (Other thrombophilia) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report antiphospholipid syndrome on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D68.61 group to?
When antiphospholipid syndrome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D68.61?
Under the General Equivalence Mappings, antiphospholipid syndrome converts to ICD-9-CM 289.81 (prim hypercoagulable st). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
