2026 ICD-10-CM Diagnosis Code D59.31Infection-associated hemolytic-uremic syndrome

ICD-10-CM Codes›D50–D89›D55-D59›D59

ICD-10-CM D59.31
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D59.31 is a billable ICD-10-CM diagnosis code for infection-associated hemolytic-uremic syndrome. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. Coders also document this condition as infection-related hemolytic uremic syndrome. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Bacterial infections and Hemolytic anemia.

Code Identity

ICD-10-CM Code
D59.31
Billable Status
Yes — Valid for Submission
Code Describes
Infection-associated hemolytic-uremic syndrome
Short Description
Infection-associated hemolytic-uremic syndrome
Same as the full description in the CMS dataset.
Parent Code
D59.3
Hemolytic-uremic syndrome

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD59Acquired hemolytic anemia
This CodeD59.31Infection-associated hemolytic-uremic syndrome

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Infection-related hemolytic uremic syndrome

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Shiga toxin-producing E. coli STEC related hemolytic uremic syndrome
  • Typical hemolytic uremic syndrome

Use Additional Code

  • code to identify associated infection, such as :
  • E. coli infection B96.2
  • Human immunodeficiency virus HIV disease B20
  • Pneumococcal meningitis G00.1
  • Pneumococcal pneumonia J13
  • Sepsis due to Streptococcus pneumoniae A40.3
  • Shigella dysenteriae A03.9
  • Streptococcus pneumoniae as the cause of diseases classified elsewhere B95.3

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Syndrome
      • hemolytic-uremic
        • atypical
          • infection-associated
    • Syndrome
      • hemolytic-uremic
        • infection-associated
    • Syndrome
      • hemolytic-uremic
        • Shiga toxin-producing E. coli [STEC] related
    • Syndrome
      • hemolytic-uremic
        • typical

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INF003
Bacterial infections
Default principal diagnosis: inpatient No · outpatient No
CCSR BLD002
Hemolytic anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Code History & ChangesHistory

Replacement D59.31 replaces the following previously assigned code(s):

  • D59.3 - Hemolytic-uremic syndrome
FY 2023AddedAdded to the ICD-10-CM code setEffective October 1, 2022.
FY 2024–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D59.31Overview

Is D59.31 (Hemolytic-uremic syndrome) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report infection-associated hemolytic-uremic syndrome on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D59.31 group to?

When infection-associated hemolytic-uremic syndrome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.