2027 ICD-10-CM Diagnosis Code D49.3Neoplasm of unspecified behavior of breast
ICD-10-CM Codes›C00–D49›D49›D49
- Billable — Valid for Submission
- Not Chronic
D49.3 is a billable ICD-10-CM diagnosis code for neoplasm of unspecified behavior of breast. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 600 through 601. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Neoplasm of areola
- Neoplasm of axillary tail of breast
- Neoplasm of breast
- Neoplasm of central portion of breast
- Neoplasm of ectopic site of breast
- Neoplasm of lower inner quadrant of breast
- Neoplasm of lower outer quadrant of breast
- Neoplasm of nipple
- Neoplasm of upper inner quadrant of breast
- Neoplasm of upper outer quadrant of breast
- Surgical margin involvement by tumor present
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D49.3: its own notes plus those printed at D49 and Chapter 2. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- 'growth' NOS
- neoplasm NOS
- new growth NOS
- tumor NOS
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- neoplasm of unspecified behavior of skin of breast (D49.2)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Notes
General instructions on how these codes are used.
- Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D49.3, its category, or a range that includes it.
Excludes1 2
These codes carry an Excludes1 note naming D49.3: they are not reported together with it, unless the two conditions are unrelated.
- D49.2 Neoplasm of unspecified behavior of bone, soft tissue, and skinneoplasm of unspecified behavior of connective tissue of breast (D49.3)
- Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromesneoplasms of unspecified behavior (D49.-) names D49.-, which includes this code
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
| Site | Malig. Primary | Malig. Secondary | Ca in situ | Benign | Uncertain | Unspec. |
|---|---|---|---|---|---|---|
| areola | C50.0 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) | C50.9 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › areola | C50.0 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › axillary tail | C50.6 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › central portion | C50.1 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › inner | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › lower | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › lower-inner quadrant | C50.3 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › lower-outer quadrant | C50.5 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › midline | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › nipple | C50.0 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › outer | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › tail (axillary) | C50.6 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › upper | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › upper-inner quadrant | C50.2 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › upper-outer quadrant | C50.4 | C79.81 | D05. | D24. | D48.6 | D49.3 |
Patient EducationClinical
Breast Diseases
Breast diseases include various conditions and changes in your breast. Most women experience breast changes at some time. Your age, hormone levels, and medicines you take may cause lumps, bumps, and discharges of fluids that are not breast milk.
The full article covers:
- What are breast diseases?
- What are the symptoms of breast disease?
- How are breast diseases diagnosed?
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Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D49.3 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D49.3Overview
What is the ICD-10 code for neoplasm of unspecified behavior of breast?
The ICD-10-CM code for neoplasm of unspecified behavior of breast is D49.3 (sometimes written as D493). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D49.3 (Neoplasms of unspecified behavior) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report neoplasm of unspecified behavior of breast on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D49.3 group to?
When neoplasm of unspecified behavior of breast is the principal diagnosis on an inpatient stay, it groups to MS-DRG 600, 601, with relative weights from 0.6014 to 0.9971 depending on complications. Higher weights mean higher Medicare reimbursement.
Can D49.3 be reported with D49.2?
Not as a rule. The Excludes1 note on D49.3 lists "neoplasm of unspecified behavior of skin of breast (D49.2)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of D49.3?
Under the General Equivalence Mappings, neoplasm of unspecified behavior of breast converts to ICD-9-CM 239.3 (breast neoplasm NOS). The mapping is a direct match.
