2026 ICD-10-CM Diagnosis Code D49.3Neoplasm of unspecified behavior of breast
ICD-10-CM Codes›D50–D89›D49›D49
- Billable — Valid for Submission
- Not Chronic
D49.3 is a billable ICD-10-CM diagnosis code for neoplasm of unspecified behavior of breast. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 600 through 601. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Neoplasm of areola
- Neoplasm of axillary tail of breast
- Neoplasm of breast
- Neoplasm of central portion of breast
- Neoplasm of ectopic site of breast
- Neoplasm of lower inner quadrant of breast
- Neoplasm of lower outer quadrant of breast
- Neoplasm of nipple
- Neoplasm of upper inner quadrant of breast
- Neoplasm of upper outer quadrant of breast
- Surgical margin involvement by tumor present
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Type 1 Excludes
- neoplasm of unspecified behavior of skin of breast D49.2
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
| Site | Malig. Primary | Malig. Secondary | Ca in situ | Benign | Uncertain | Unspec. |
|---|---|---|---|---|---|---|
| areola | C50.0 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) | C50.9 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › areola | C50.0 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › axillary tail | C50.6 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › central portion | C50.1 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › inner | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › lower | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › lower-inner quadrant | C50.3 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › lower-outer quadrant | C50.5 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › midline | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › nipple | C50.0 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › outer | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › tail (axillary) | C50.6 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › upper | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › upper-inner quadrant | C50.2 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › upper-outer quadrant | C50.4 | C79.81 | D05. | D24. | D48.6 | D49.3 |
Patient EducationClinical
Breast Diseases
Breast diseases include various conditions and changes in your breast. Most women experience breast changes at some time. Your age, hormone levels, and medicines you take may cause lumps, bumps, and discharges of fluids that are not breast milk.
The full article covers:
- What are breast diseases?
- What are the symptoms of breast disease?
- How are breast diseases diagnosed?
- What are the treatments for breast disease?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D49.3 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D49.3Overview
Is D49.3 (Neoplasms of unspecified behavior) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report neoplasm of unspecified behavior of breast on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D49.3 group to?
When neoplasm of unspecified behavior of breast is the principal diagnosis on an inpatient stay, it groups to MS-DRG 600, 601, with relative weights from 0.6050 to 1.0416 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D49.3?
Under the General Equivalence Mappings, neoplasm of unspecified behavior of breast converts to ICD-9-CM 239.3 (breast neoplasm NOS). The mapping is a direct match.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
