2026 ICD-10-CM Diagnosis Code D35.2Benign neoplasm of pituitary gland

ICD-10-CM Codes›C00–D49›D10-D36›D35

ICD-10-CM D35.2
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D35.2 is a billable ICD-10-CM diagnosis code for benign neoplasm of pituitary gland. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Benign neoplasms.

Code Identity

ICD-10-CM Code
D35.2
Billable Status
Yes — Valid for Submission
Code Describes
Benign neoplasm of pituitary gland
Short Description
Benign neoplasm of pituitary gland
Same as the full description in the CMS dataset.
Parent Code
D35
Benign neoplasm of other and unspecified endocrine glands

Code Classification

ChapterC00–D49Neoplasms
SectionD10-D36Benign neoplasms, except benign neuroendocrine tumors
CategoryD35Benign neoplasm of other and unspecified endocrine glands
This CodeD35.2Benign neoplasm of pituitary gland

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • ACTH-dependent Cushing's syndrome
  • Benign neoplasm of craniopharyngeal duct
  • Benign neoplasm of pituitary gland
  • Benign neoplasm of pituitary gland and craniopharyngeal duct
  • Corticotroph adenoma
  • Dermoid cyst of brain
  • Epidermoid cyst of brain
  • Epidermoid cyst of pituitary gland
  • Familial isolated pituitary adenoma
  • Functioning pituitary neoplasm
  • Functionless pituitary adenoma
  • Functionless pituitary neoplasm
  • Germ cell tumor of the brain
  • Gonadotroph adenoma
  • Granular cell tumor
  • Granular cell tumor of neurohypophysis
  • Hamartoma of brain
  • Hamartoma of hypothalamus
  • Hamartoma of pituitary and hypothalamus
  • Hypercortisolism due to pituitary adenoma
  • Hypopituitarism due to pituitary neoplasm
  • Invasive benign pituitary adenoma
  • Macroprolactinoma
  • Mass of neurohypophysis
  • Microprolactinoma
  • Mixed-functioning pituitary adenoma
  • Neoplasm of craniopharyngeal duct
  • Pituitary adenoma
  • Pituitary adenoma with extrasellar extension
  • Pituitary cyst
  • Pituitary dermoid and epidermoid cysts
  • Pituitary macroadenoma
  • Pituitary macroadenoma with extrasellar extension
  • Pituitary mesoadenoma
  • Pituitary microadenoma
  • Prolactinoma
  • Secondary hyperprolactinemia
  • Secondary hyperprolactinemia due to prolactin-secreting tumor
  • Somatomammotropinoma
  • Somatotroph adenoma
  • Spindle cell oncocytoma of posterior pituitary gland
  • Suprasellar extension of pituitary adenoma
  • Thyrotoxicosis due to inappropriate TSH secretion
  • Thyrotoxicosis due to TSHoma
  • Thyrotroph adenoma
  • Thyrotropin overproduction

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Adenoma
      • acidophil
        • unspecified site
    • Adenoma
      • acidophil-basophil, mixed
        • unspecified site
    • Adenoma
      • basophil
        • unspecified site
    • Adenoma
      • basophil-acidophil, mixed
        • unspecified site
    • Adenoma
      • chromophobe
        • unspecified site
    • Adenoma
      • eosinophil
        • unspecified site
    • Adenoma
      • mucoid cell
        • unspecified site
    • Prolactinoma
      • unspecified site

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO073
Benign neoplasms
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Empty Sella Syndrome

    a condition when the sella turcica is not filled with pituitary tissue. the pituitary gland is either compressed, atrophied, or removed. there are two types: (1) primary empty sella is due a defect in the sella diaphragm leading to arachnoid herniation into the sellar space; (2) secondary empty sella is associated with the removal or treatment of pituitary neoplasms.

  • Sella Turcica

    a bony prominence situated on the upper surface of the body of the sphenoid bone. it houses the pituitary gland.

  • Prolactinoma

    a pituitary adenoma which secretes prolactin, leading to hyperprolactinemia. clinical manifestations include amenorrhea; galactorrhea; impotence; headache; visual disturbances; and cerebrospinal fluid rhinorrhea.

  • Granular Cell Tumor

    unusual tumor affecting any site of the body, but most often encountered in the head and neck. considerable debate has surrounded the histogenesis of this neoplasm; however, it is considered to be a myoblastoma of, usually, a benign nature. it affects women more often than men. when it develops beneath the epidermis or mucous membrane, it can lead to proliferation of the squamous cells and mimic squamous cell carcinoma.

Table of NeoplasmsClinical

Anatomical sites in the Table of Neoplasms that reference this code family.

SiteMalig.
Primary		Malig.
Secondary		Ca
in situ		BenignUncertainUnspec.
craniobuccal pouchC75.2C79.89D09.3D35.2D44.3D49.7
fossa (of) › pituitaryC75.1C79.89D09.3D35.2D44.3D49.7
hypophysisC75.1C79.89D09.3D35.2D44.3D49.7
intrasellarC75.1C79.89D09.3D35.2D44.3D49.7
pituitary (body) (fossa) (gland) (lobe)C75.1C79.89D09.3D35.2D44.3D49.7
Rathke's pouchC75.1C79.89D09.3D35.2D44.3D49.7
sella turcicaC75.1C79.89D09.3D35.2D44.3D49.7

Patient EducationClinical

Benign Tumors

Tumors are abnormal growths in your body. They can be either benign or malignant. Benign tumors aren't cancer. Malignant ones are. Benign tumors grow only in one place. They cannot spread or invade other parts of your body. Even so, they can be dangerous if they press on vital organs, such as your brain.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D35.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
227.3 Benign neo pituitary
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D35.2Overview

Is D35.2 (Benign neoplasm of other and unspecified endocrine glands) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report benign neoplasm of pituitary gland on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D35.2 group to?

When benign neoplasm of pituitary gland is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D35.2?

Under the General Equivalence Mappings, benign neoplasm of pituitary gland converts to ICD-9-CM 227.3 (benign neo pituitary). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.