2027 ICD-10-CM Diagnosis Code D22.121Melanocytic nevi of left upper eyelid, including canthus

ICD-10-CM Codes›C00–D49›D10-D36›D22

ICD-10-CM D22.121
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

D22.121 is a billable ICD-10-CM diagnosis code for melanocytic nevi of left upper eyelid, including canthus. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 124 through 125. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Benign neoplasms.

Code Identity

ICD-10-CM Code
D22.121
Billable Status
Yes — Valid for Submission
Code Describes
Melanocytic nevi of left upper eyelid, including canthus
Short Description
Melanocytic nevi of left upper eyelid, including canthus
Same as the full description in the CMS dataset.
Parent Code
D22.12
Melanocytic nevi of left eyelid, including canthus

Code Classification

ChapterC00–D49Neoplasms
SectionD10-D36Benign neoplasms, except benign neuroendocrine tumors
CategoryD22Melanocytic nevi
This CodeD22.121Melanocytic nevi of left upper eyelid, including canthus

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Benign neoplasm of skin of left upper eyelid
  • Congenital melanocytic nevus of face
  • Congenital melanocytic nevus of skin of left upper eyelid
  • Congenital melanocytic nevus of skin of upper eyelid
  • Epidermal nevus of left upper eyelid
  • Hyperpigmentation of eyelid
  • Hyperpigmentation of left eyelid and periocular area
  • Melanocytic nevus of left upper eyelid
  • Melanocytic nevus of upper eyelid
  • Pigmented hairy epidermal nevus of face
  • Pigmented hairy epidermal nevus of left upper eyelid
  • Pigmented hairy epidermal nevus of upper eyelid

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to D22.121: its own notes plus those printed at D22 and Chapter 2. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From D22 Melanocytic nevi applies to 20 codes
  • atypical nevus
  • blue hairy pigmented nevus
  • nevus NOS

Notes

General instructions on how these codes are used.

From Chapter 2 (C00-D49) Neoplasms applies to 1,730 codes
  • Functional activity
  • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
  • Morphology [Histology]
  • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
  • Primary malignant neoplasms overlapping site boundaries
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
  • Malignant neoplasm of ectopic tissue
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name D22.121, its category, or a range that includes it.

Excludes1 2

These codes carry an Excludes1 note naming D22.121: they are not reported together with it, unless the two conditions are unrelated.

  • D31 Benign neoplasm of eye and adnexa
    benign neoplasm of skin of eyelid (D22.1-, D23.1-) names D22.1-, which includes this code
  • I78.1 Nevus, non-neoplastic
    nevus NOS (D22.-) names D22.-, which includes this code

Excludes2 10

These codes carry an Excludes2 note naming D22.121: its condition is not part of those codes, and both may be reported when the patient has both.

  • D18 Hemangioma and lymphangioma, any site
    blue or pigmented nevus (D22.-) names D22.-, which includes this code
  • D18 Hemangioma and lymphangioma, any site
    nevus NOS (D22.-) names D22.-, which includes this code
  • D23 Other benign neoplasms of skin
    melanocytic nevi (D22.-) names D22.-, which includes this code
  • I78.1 Nevus, non-neoplastic
    blue nevus (D22.-) names D22.-, which includes this code
  • I78.1 Nevus, non-neoplastic
    hairy nevus (D22.-) names D22.-, which includes this code
  • I78.1 Nevus, non-neoplastic
    melanocytic nevus (D22.-) names D22.-, which includes this code
  • I78.1 Nevus, non-neoplastic
    pigmented nevus (D22.-) names D22.-, which includes this code
  • Q82.5 Congenital non-neoplastic nevus
    nevus NOS (D22.-) names D22.-, which includes this code
  • Q82.5 Congenital non-neoplastic nevus
    melanocytic nevus (D22.-) names D22.-, which includes this code
  • Q82.5 Congenital non-neoplastic nevus
    pigmented nevus (D22.-) names D22.-, which includes this code

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO073
Benign neoplasms
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Nevus, Pigmented

    a nevus containing melanin. the term is usually restricted to nevocytic nevi (round or oval collections of melanin-containing nevus cells occurring at the dermoepidermal junction of the skin or in the dermis proper) or moles, but may be applied to other pigmented nevi.

Patient EducationClinical

Birthmarks

Birthmarks are abnormalities of the skin that are present when a baby is born. There are two types of birthmarks. Vascular birthmarks are made up of blood vessels that haven't formed correctly. They are usually red. Two types of vascular birthmarks are hemangiomas and port-wine stains.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code History & ChangesHistory

Replacement D22.121 replaces the following previously assigned code(s):

  • D22.12 - Melanocytic nevi of left eyelid, including canthus
FY 2019AddedAdded to the ICD-10-CM code setEffective October 1, 2018.
FY 2020–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About D22.121Overview

What is the ICD-10 code for melanocytic nevi of left upper eyelid, including canthus?

The ICD-10-CM code for melanocytic nevi of left upper eyelid, including canthus is D22.121 (sometimes written as D22121). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is D22.121 (Melanocytic nevi of left eyelid, including canthus) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report melanocytic nevi of left upper eyelid, including canthus on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does D22.121 group to?

When melanocytic nevi of left upper eyelid, including canthus is the principal diagnosis on an inpatient stay, it groups to MS-DRG 125, 124, with relative weights from 0.7699 to 1.2470 depending on complications. Higher weights mean higher Medicare reimbursement.