2026 ICD-10-CM Diagnosis Code C83.390Primary central nervous system lymphoma

ICD-10-CM Codes›C00–D49›C81-C96›C83

ICD-10-CM C83.390
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

C83.390 is a billable ICD-10-CM diagnosis code for primary central nervous system lymphoma. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 820 through 825, 840 through 842, 974 through 976. Coders also document this condition as diffuse large B-cell lymphoma of central nervous system. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Non-Hodgkin lymphoma.

Code Identity

ICD-10-CM Code
C83.390
Billable Status
Yes — Valid for Submission
Code Describes
Primary central nervous system lymphoma
Short Description
Primary central nervous system lymphoma
Same as the full description in the CMS dataset.
Parent Code
C83.39
Diffuse large B-cell lymphoma, extranodal and solid organ sites

Code Classification

ChapterC00–D49Neoplasms
SectionC81-C96Malignant neoplasms of lymphoid, hematopoietic and related tissue
CategoryC83Non-follicular lymphoma
This CodeC83.390Primary central nervous system lymphoma

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Diffuse large B-cell lymphoma of central nervous system
  • Non-Hodgkin's lymphoma of central nervous system

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • PCNSL of brain
  • PCNSL of meninges
  • PCNSL of spinal cord
  • PCNSL NOS

Type 1 Excludes

  • Primary central nervous system lymphoma, Burkitt C83.79
  • Primary central nervous system lymphoma, lymphoblastic C83.59
  • Primary central nervous system lymphoma, other C83.89
  • Primary central nervous system lymphoma, peripheral T-cell C84.49

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Lymphoma(of) (malignant)
      • diffuse large cell
        • primary central nervous system (brain) (meninges) (PCNSL) (spinal cord)
    • Lymphoma(of) (malignant)
      • primary central nervous system (brain) (meninges) (PCNSL) (spinal cord)
    • Lymphoma(of) (malignant)
      • primary central nervous system (brain) (meninges) (PCNSL) (spinal cord)
        • diffuse large B-cell

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO058
Non-Hodgkin lymphoma
Default principal diagnosis: inpatient Yes · outpatient Yes

Code History & ChangesHistory

Replacement C83.390 replaces the following previously assigned code(s):

  • Z85.72 - Personal history of non-Hodgkin lymphomas
FY 2025AddedAdded to the ICD-10-CM code setEffective October 1, 2024.
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About C83.390Overview

Is C83.390 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report primary central nervous system lymphoma on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does C83.390 group to?

When primary central nervous system lymphoma is the principal diagnosis on an inpatient stay, it groups to MS-DRG 820, 821, 822, 823, 824, 825, 840, 841, 842, 974, 975, 976, with relative weights from 0.8945 to 5.8648 depending on complications. Higher weights mean higher Medicare reimbursement.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.