2026 ICD-10-CM Diagnosis Code A53.9Syphilis, unspecified

AHRQ’s CCSR groups this code into broader clinical categories.

• Longitudinal Studies

  studies in which variables relating to an individual or group of individuals are assessed over a period of time.

• Neurosyphilis

  infections of the central nervous system caused by treponema pallidum which present with a variety of clinical syndromes. the initial phase of infection usually causes a mild or asymptomatic meningeal reaction. the meningovascular form may present acutely as brain infarction. the infection may also remain subclinical for several years. late syndromes include general paresis; tabes dorsalis; meningeal syphilis; syphilitic optic atrophy; and spinal syphilis. general paresis is characterized by progressive dementia; dysarthria; tremor; myoclonus; seizures; and argyll-robertson pupils. (adams et al., principles of neurology, 6th ed, pp722-8)

• Syphilis

  a contagious venereal disease caused by the spirochete treponema pallidum.

• Syphilis Serodiagnosis

  serologic tests for syphilis.

• Syphilis, Cardiovascular

  cardiovascular manifestations of syphilis, an infection of treponema pallidum. in the late stage of syphilis, sometimes 20-30 years after the initial infection, damages are often seen in the blood vessels including the aorta and the aortic valve. clinical signs include syphilitic aortitis, aortic insufficiency, or aortic aneurysm.

• Syphilis, Congenital

  syphilis acquired in utero and manifested by any of several characteristic tooth (hutchinson's teeth) or bone malformations and by active mucocutaneous syphilis at birth or shortly thereafter. ocular and neurologic changes may also occur.

• Syphilis, Cutaneous

  cutaneous lesions arising from infection with treponema pallidum. in the primary stage, 18-21 days following infection, one or more chancres appear. if untreated, the subsequent stages of the disease appear as syphilids. these eruptions are superficial, nondestructive, exanthematic, transient, macular roseolas that may later be maculopapular or papular polymorphous or scaly, pustular, pigmented eruptions.(arnold, odom, and james, andrew's diseases of the skin, 8th ed, p409)

• Syphilis, Latent

  the stage of syphilis that occurs following the primary (chancre) and secondary stages. the patient is asymptomatic at the latent stage but remains seropositive for the spirochete.

• Tabes Dorsalis

  parenchymatous neurosyphilis marked by slowly progressive degeneration of the posterior columns, posterior roots, and ganglia of the spinal cord. the condition tends to present 15 to 20 years after the initial infection and is characterized by lightening-like pains in the lower extremities, urinary incontinence; ataxia; severely impaired position and vibratory sense, abnormal gait (see gait disorders, neurologic), optic atrophy; argyll-robertson pupils, hypotonia, hyperreflexia, and trophic joint degeneration (charcot's joint; see arthropathy, neurogenic). (from adams et al., principles of neurology, 6th ed, p726)

• Anetoderma

  benign dermatosis caused by a loss of dermal elastic tissue resulting in localized sac-like areas of flaccid skin. it can be either primary (idiopathic) or secondary to other skin conditions, penicillamine use, or premature birth.

• Treponema pallidum

  the causative agent of venereal and non-venereal syphilis as well as yaws.

• Late Latent Congenital Syphilis

  the occurrence of syphilis symptoms in individuals who were infected before or during birth and have not exhibited signs of the disease for over a year.

• Cardiovascular Syphilis|Cardiovascular syphilis, unspecified

  complications of syphilis seen in the cardiovascular system. these may include aortitis, aortic valve insufficiency with regurgitation, coronary artery stenosis, aortic root aneurysm and mucinous myocarditis.

• Congenital Syphilis

  a life-threatening bacterial infection of the newborn caused by treponema pallidum. it is transmitted to the infant from a mother with syphilis through the placenta during pregnancy. signs and symptoms include irritability, fever, failure to thrive, saddle nose, cutaneous rash, and pneumonia.

• Early Latent Syphilis

  latent syphilis when infection was acquired less than twelve months previously.

• Late Latent Syphilis

  latent syphilis when infection was acquired more than twelve months previously.

• Latent Syphilis

  a stage of syphilis characterized by the serologic evidence of infection by treponema pallidum without evidence of accompanying signs or symptoms related to the disease.

• Nephrotic Syndrome - Syphilis Associated|Syphilis Associated Nephrotic Syndrome

  nephrotic syndrome associated with a syphilis infection.

• Neurosyphilis

  infection of the brain or spinal cord by treponema pallidum. it occurs many years following the original infection which remained untreated. signs and symptoms include abnormal gait, blindness, depression, paralysis, seizures and dementia.

• Other Cardiovascular Syphilis|Other cardiovascular syphilis

  evidence of other cardiovascular syphilis not specified elsewhere.

• Primary Syphilis

  the subclinical or symptomatic stage of syphilis, occurring at an average of three weeks after contact with an infected individual. it manifests with one or more painless, indurated ulcers (chancres) of the skin or mucous membranes at the site of inoculation. these lesions heal spontaneously within a few weeks.

• Secondary Syphilis

  the secondary stage of syphilis typically that is characterized by generalized rash (including palms and soles), mucocutaneous lesions, and lymphadenopathy. it usually begins one to two months after the primary stage.

• Syphilis

  a contagious bacterial infection caused by the spirochete treponema pallidum. it is a sexually transmitted disorder, although it can also be transmitted from the mother to the fetus in utero. typically, it is initially manifested with a single sore which heals without treatment. if the infection is left untreated, the initial stage is followed by skin rash and mucous membrane lesions. a late stage follows, which is characterized by damage of the internal organs, including the nervous system.

• Syphilis of Liver and Other Viscera|Syphilis of liver and Other viscera

  evidence of syphilis of liver and other viscera.

• Tertiary Syphilis|Late Syphilis

  a stage of syphilis that occurs fifteen to thirty years after the initial infection; it can include gumma formation and cardiovascular or central nervous system involvement (neurosyphilis).

• Anetoderma

  a dermatologic condition characterized by focal loss of elastic tissue. clinically it presents with atrophic depressions or saccular outpouchings of the skin.

Syphilis

Syphilis is a sexually transmitted infection (STI) caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy.

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