2027 ICD-10-CM Diagnosis Code Z17.411Hormone receptor positive with human epidermal growth factor receptor 2 negative status

ICD-10-CM Codes›Z00–Z99›Z17›Z17

ICD-10-CM Z17.411
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

Z17.411 is a billable ICD-10-CM diagnosis code for hormone receptor positive with human epidermal growth factor receptor 2 negative status. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 951. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. Coders also document this condition as HER2-positive carcinoma of breast. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Genetic susceptibility to disease.

Code Identity

ICD-10-CM Code
Z17.411
Billable Status
Yes — Valid for Submission
Code Describes
Hormone receptor positive with human epidermal growth factor receptor 2 negative status
Short Description
Hormone recept pos w hmn epdrml grth fctr recept 2 neg stat
Parent Code
Z17.41
Hormone receptor positive

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ17Estrogen, and other hormones and factors receptor status
CategoryZ17Estrogen, and other hormones and factors receptor status
This CodeZ17.411Hormone receptor positive with human epidermal growth factor receptor 2 negative status

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z17.411.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z17.411 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Estrogen, and other hormones and factors receptor status (Z17).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • HER2-positive carcinoma of breast
  • Hormone receptor positive and human epidermal growth factor receptor 2 positive malignant neoplasm of breast
  • Hormone receptor positive malignant neoplasm of breast
  • Hormone receptor positive neoplasm

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to Z17.411: its own notes plus those printed at Z17.4, Z17, and Chapter 21. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • HR+ with HER2-

Code First

The underlying condition named in the note is sequenced before this code.

From Z17 Estrogen, and other hormones and factors receptor status applies to 10 codes
  • malignant neoplasm, such as:
  • malignant neoplasm of breast (C50.-)
  • malignant neoplasm of ovary (C56.-)

Notes

General instructions on how these codes are used.

From Z17.4 Combined receptor status applies to 4 codes
  • Assign a code from subcategory Z17.4- when only a combined receptor status is documented
From Z17 Estrogen, and other hormones and factors receptor status applies to 10 codes
From Chapter 21 (Z00-Z99) Factors influencing health status and contact with health services applies to 1,425 codes
  • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
  • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
  • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name Z17.411, its category, or a range that includes it.

Use Additional Code 1

These codes say to use an additional code from the note, and Z17.411 is one of the codes named.

  • C50 Malignant neoplasm of breast
    code to identify estrogen, and other hormones and factors receptor status (Z17.-) names Z17.-, which includes this code

Notes 1

These notes mention Z17.411.

  • Z17.4 Combined receptor status
    Assign a code from subcategory Z17.4- when only a combined receptor status is documented names Z17.4-, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC029
Genetic susceptibility to disease
Default principal diagnosis: inpatient No · outpatient No

Code HistoryHistory

FY 2025AddedAdded to the ICD-10-CM code setEffective October 1, 2024.
FY 2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About Z17.411Overview

Is Z17.411 (Hormone receptor positive) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hormone receptor positive with human epidermal growth factor receptor 2 negative status on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does Z17.411 group to?

On inpatient claims, hormone receptor positive with human epidermal growth factor receptor 2 negative status maps to MS-DRG 951 (other Factors Influencing Health Status), which carries a relative weight of 0.5574. Higher weights mean higher Medicare reimbursement.

Can Z17.411 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because hormone receptor positive with human epidermal growth factor receptor 2 negative status describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z17.411 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for hormone receptor positive with human epidermal growth factor receptor 2 negative status on inpatient claims. The code appears in the Estrogen, and other hormones and factors receptor status (Z17) range of the CMS exempt list.

What is coded first with Z17.411?

The Code First note at Z17, which applies to Z17.411, reads: malignant neoplasm, such as: malignant neoplasm of breast (C50.-); malignant neoplasm of ovary (C56.-). When one of these applies, it is sequenced before Z17.411.