2025 ICD-10-CM Diagnosis Code Z17.421
Hormone receptor negative with human epidermal growth factor receptor 2 negative status
- ICD-10-CM Code:
- Z17.421
- ICD-10 Code for:
- Hormone recept neg w hmn epdrml grth fctr recept 2 neg stat
- Is Billable?
- Yes - Valid for Submission
- Code Navigator:
Z17.421 is a billable diagnosis code used to specify a medical diagnosis of hormone receptor negative with human epidermal growth factor receptor 2 negative status. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2024 through September 30, 2025. The code is exempt from present on admission (POA) reporting for inpatient admissions to general acute care hospitals.
This code describes a circumstance which influences the patient's health status but not a current illness or injury. The code is unacceptable as a principal diagnosis.
Clinical Information
Advanced Hormone Receptor-Negative Breast Carcinoma|Advanced Hormone Receptor Negative Breast Carcinoma
hormone receptor-negative breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.Hormone Receptor Negative
a finding indicating that the tumor cells in a tissue sample are negative for hormone receptors.Hormone Receptor-Negative Breast Carcinoma|ER and PR Negative Breast Carcinoma|Estrogen Receptor and Progesterone Receptor Negative Breast Carcinoma|Hormone Receptor Negative Breast Adenocarcinoma|Hormone Receptor Negative Breast Carcinoma|Hormone Receptor Negative Breast Carcinoma
breast adenocarcinoma that is negative for hormone receptors.Metastatic Hormone Receptor-Negative Breast Carcinoma|Metastatic Hormone Receptor Negative Breast Carcinoma
hormone receptor-negative breast carcinoma that has spread from its original site of growth to another anatomic site.Recurrent Hormone Receptor-Negative Breast Carcinoma|Recurrent Hormone Receptor Negative Breast Adenocarcinoma|Recurrent Hormone Receptor Negative Breast Carcinoma|Recurrent Hormone Receptor-Negative Breast Adenocarcinoma
the reemergence of hormone receptor-negative breast carcinoma after a period of remission.Refractory Hormone Receptor-Negative Breast Carcinoma|Refractory Hormone Receptor Negative Breast Adenocarcinoma|Refractory Hormone Receptor Negative Breast Carcinoma|Refractory Hormone Receptor-Negative Breast Adenocarcinoma
hormone receptor-negative breast carcinoma that is resistant to treatment.Unresectable Hormone Receptor-Negative Breast Carcinoma|Unresectable Hormone Receptor Negative Breast Carcinoma
hormone receptor-negative breast carcinoma that is not amenable to surgical resection.
New 2025 ICD-10-CM Code
Z17.421 is new to ICD-10-CM code set for the FY 2025, effective October 1, 2024. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2024. This is a new and revised code for the FY 2025 (October 1, 2024 - September 30, 2025).
Tabular List of Diseases and Injuries
The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.
Inclusion Terms
Inclusion TermsThese terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
- HR- with HER2-
- TNBC
- Triple negative breast cancer
Index to Diseases and Injuries References
The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).
- - Status (post) - See Also: Presence (of);
- - Triple - See Also: Accessory;
- - negative breast cancer (TNBC) - Z17.421
Code Edits
The Medicare Code Editor (MCE) detects errors and inconsistencies in ICD-10-CM diagnosis coding that can affect Medicare claim validity. These Medicare code edits help medical coders and billing professionals determine when a diagnosis code is not appropriate as a principal diagnosis, does not meet coverage criteria. Use this list to verify whether a code is valid for Medicare billing and to avoid claim rejections or denials due to diagnosis coding issues.
Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.
Present on Admission (POA)
Z17.421 is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here.
CMS POA Indicator Options and Definitions
POA Indicator: Y
Reason: Diagnosis was present at time of inpatient admission.
CMS Pays CC/MCC DRG? YES
POA Indicator: N
Reason: Diagnosis was not present at time of inpatient admission.
CMS Pays CC/MCC DRG? NO
POA Indicator: U
Reason: Documentation insufficient to determine if the condition was present at the time of inpatient admission.
CMS Pays CC/MCC DRG? NO
POA Indicator: W
Reason: Clinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.
CMS Pays CC/MCC DRG? YES
POA Indicator: 1
Reason: Unreported/Not used - Exempt from POA reporting.
CMS Pays CC/MCC DRG? NO
