2026 ICD-10-CM Diagnosis Code Z17.1Estrogen receptor negative status [ER-]

ICD-10-CM Codes›Z00–Z99›Z17›Z17

ICD-10-CM Z17.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z17.1 is a billable ICD-10-CM diagnosis code for estrogen receptor negative status [ER-]. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. Coders also document this condition as estrogen receptor negative neoplasm. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Genetic susceptibility to disease.

Code Identity

ICD-10-CM Code
Z17.1
Billable Status
Yes — Valid for Submission
Code Describes
Estrogen receptor negative status [ER-]
Short Description
Estrogen receptor negative status [ER-]
Same as the full description in the CMS dataset.
Parent Code
Z17
Estrogen, and other hormones and factors receptor status

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ17Estrogen, and other hormones and factors receptor status
CategoryZ17Estrogen, and other hormones and factors receptor status
This CodeZ17.1Estrogen receptor negative status [ER-]

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z17.1.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z17.1 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Estrogen receptor negative neoplasm
  • Hormone receptor negative neoplasm

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Status(post)
      • estrogen receptor
        • negative

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC029
Genetic susceptibility to disease
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Breast Cancer

Breast cancer is a cancer that starts in breast tissue. It happens when cells in the breast change and grow out of control. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor.

The full article covers:

  • What is breast cancer?
  • What are the types of breast cancer?
  • What causes breast cancer?
  • Who is at risk for breast cancer?
  • What are the signs and symptoms of breast cancer?
  • How is breast cancer diagnosed?
  • What are the treatments for breast cancer?
  • Can breast cancer be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Z17.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V86.1 Estrogen recep neg stat
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z17.1Overview

Is Z17.1 (Estrogen, and other hormones and factors receptor status) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report estrogen receptor negative status [ER-] on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can Z17.1 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because estrogen receptor negative status [ER-] describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z17.1 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for estrogen receptor negative status [ER-] on inpatient claims.

What is the ICD-9 equivalent of Z17.1?

Under the General Equivalence Mappings, estrogen receptor negative status [ER-] converts to ICD-9-CM V86.1 (estrogen recep neg stat). The mapping is approximate, so confirm the match fits the documentation.