2026 ICD-10-CM Diagnosis Code T65.841AToxic effect of xylazine, accidental (unintentional), initial encounter
T65.841A is a billable ICD-10-CM diagnosis code for toxic effect of xylazine, accidental (unintentional), initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 917 through 918.
Code Identity
Code Classification
Coding GuidelinesGuidance
The appropriate 7th character is to be added to each code from block Toxic effect of other and unspecified substances (T65). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical InformationClinical
Xylazine
an adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in veterinary medicine.
Table of Drugs and ChemicalsClinical
Code History & ChangesHistory
New Code T65.841A was added to the ICD-10-CM code set for FY 2026, effective October 1, 2025.
Replacement T65.841A replaces the following previously assigned code(s):
- T65.891A - Toxic effect of substances, accidental (unintentional), init
Questions About T65.841AOverview
Is T65.841A (Toxic effect of xylazine, accidental (unintentional)) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report toxic effect of xylazine, accidental (unintentional), initial encounter on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character A in T65.841A mean?
The final character A marks the initial encounter: use it while the patient is receiving active treatment for toxic effect of xylazine, accidental (unintentional), such as an emergency visit or first evaluation.
What MS-DRG does T65.841A group to?
When toxic effect of xylazine, accidental (unintentional), initial encounter is the principal diagnosis on an inpatient stay, it groups to MS-DRG 917, 918, with relative weights from 0.8571 to 1.5684 depending on complications. Higher weights mean higher Medicare reimbursement.
