2026 ICD-10-CM Diagnosis Code R80.1Persistent proteinuria, unspecified

ICD-10-CM Codes›R00–R99›R80-R82›R80

ICD-10-CM R80.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R80.1 is a billable ICD-10-CM diagnosis code for persistent proteinuria, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 695 through 696. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Proteinuria.

Code Identity

ICD-10-CM Code
R80.1
Billable Status
Yes — Valid for Submission
Code Describes
Persistent proteinuria, unspecified
Short Description
Persistent proteinuria, unspecified
Same as the full description in the CMS dataset.
Parent Code
R80
Proteinuria

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR80-R82Abnormal findings on examination of urine, without diagnosis
CategoryR80Proteinuria
This CodeR80.1Persistent proteinuria, unspecified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Microalbuminuria
  • Microalbuminuria due to type 1 diabetes mellitus
  • Microalbuminuria due to type 2 diabetes mellitus
  • Microalbuminuric diabetic nephropathy
  • Persistent albuminuria
  • Persistent microalbuminuria due to type 1 diabetes mellitus
  • Persistent microalbuminuria due to type 2 diabetes mellitus
  • Persistent proteinuria
  • Persistent proteinuria due to type 1 diabetes mellitus
  • Persistent proteinuria due to type 2 diabetes mellitus
  • Proteinuria due to type 1 diabetes mellitus
  • Proteinuria due to type 2 diabetes mellitus

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Proteinuria
      • persistent

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR GEN010
Proteinuria
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Pre-Eclampsia

    a complication of pregnancy, characterized by a complex of symptoms including maternal hypertension and proteinuria with or without pathological edema. symptoms may range between mild and severe. pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.

  • Proteinuria

    the presence of proteins in the urine, an indicator of kidney diseases.

  • Kidney Diseases

    pathological processes of the kidney or its component tissues.

  • Overflow Proteinuria|Overflow proteinuria

    a pathologic condition that occurs when the plasma concentration of low-molecular weight proteins exceeds the tubular capacity to reabsorb the filtered proteins.

  • Grade 1 Proteinuria, CTCAE|Grade 1 Proteinuria|Grade 1 Proteinuria

    1+ proteinuria; urinary protein > or = to uln-<1.0 g/24 hrs

  • Grade 2 Proteinuria, CTCAE|Grade 2 Proteinuria|Grade 2 Proteinuria

    adult: 2+ and 3+ proteinuria; urinary protein 1.0-<3.5 g/24 hrs; pediatric: urine p/c (protein/creatinine) ratio 0.5-1.9

  • Grade 3 Proteinuria, CTCAE|Grade 3 Proteinuria|Grade 3 Proteinuria

    adult: urinary protein >=3.5 g/24 hrs; 4+ proteinuria; pediatric: urine p/c (protein/creatinine) ratio >1.9

  • Maternal Proteinuria

    the presence of excessive protein, chiefly albumin but also globulin, in the urine of a pregnant woman.

  • Nephrotic Range Proteinuria

    in children, urine protein greater than or equal to 40mg/m^2/h; alternatively, greater than or equal to 0.25gm/mmol creatinine or 2gm/gm creatinine obtained from a first morning specimen.

  • Proteinuria

    the presence of abnormal amounts of protein in the urine.

  • Proteinuria, CTCAE 5.0|Proteinuria|Proteinuria

    a disorder characterized by laboratory test results that indicate the presence of excessive protein in the urine. it is predominantly albumin, but also globulin.

Patient EducationClinical

Urine and Urination

Your kidneys make urine by filtering wastes and extra water from your blood. The waste is called urea. Your blood carries it to the kidneys. From the kidneys, urine travels down two thin tubes called ureters to the bladder. The bladder stores urine until you are ready to urinate.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert R80.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
791.0 Proteinuria
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R80.1Overview

Is R80.1 (Proteinuria) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report persistent proteinuria, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does R80.1 group to?

When persistent proteinuria, unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 695, 696, with relative weights from 0.6890 to 1.1438 depending on complications. Higher weights mean higher Medicare reimbursement.

Can R80.1 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the persistent proteinuria, unspecified is established, that condition takes the principal position instead.

What is the ICD-9 equivalent of R80.1?

Under the General Equivalence Mappings, persistent proteinuria, unspecified converts to ICD-9-CM 791.0 (proteinuria). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.