2026 ICD-10-CM Diagnosis Code R59.0Localized enlarged lymph nodes

ICD-10-CM Codes›R00–R99›R50-R69›R59

ICD-10-CM R59.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R59.0 is a billable ICD-10-CM diagnosis code for localized enlarged lymph nodes. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other general signs and symptoms.

Code Identity

ICD-10-CM Code
R59.0
Billable Status
Yes — Valid for Submission
Code Describes
Localized enlarged lymph nodes
Short Description
Localized enlarged lymph nodes
Same as the full description in the CMS dataset.
Parent Code
R59
Enlarged lymph nodes

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR50-R69General symptoms and signs
CategoryR59Enlarged lymph nodes
This CodeR59.0Localized enlarged lymph nodes

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Anterior auricular lymphadenopathy
  • Anterior cervical lymphadenopathy
  • Anterior mediastinal lymphadenopathy
  • Anterior tibial lymphadenopathy
  • Aortic lymphadenopathy
  • Apical axillary lymphadenopathy
  • Appendicular lymphadenopathy
  • Axillary lymphadenopathy
  • Bilateral hilar adenopathy
  • Bilateral hilar adenopathy syndrome
  • Brachial lymphadenopathy
  • Celiac lymphadenopathy
  • Central axillary lymphadenopathy
  • Cervical lymphadenopathy
  • Colic lymphadenopathy
  • Common duct lymphadenopathy
  • Cubital lymphadenopathy
  • Cystic lymphadenopathy
  • Deep inguinal lymphadenopathy
  • Deep lymphadenopathy
  • Deep popliteal lymphadenopathy
  • Delphian lymphadenopathy
  • Diaphragmatic lymphadenopathy
  • Disorder of intra-abdominal lymph nodes
  • Enlarged submandibular lymph gland
  • Epigastric lymphadenopathy
  • Epitrochlear lymphadenopathy
  • Esophageal lymphadenopathy
  • External iliac lymphadenopathy
  • Facial lymphadenopathy
  • Fibular lymphadenopathy
  • Focal lymphadenopathy
  • Gastro-omental lymphadenopathy
  • Gluteal lymphadenopathy
  • Gut-associated lymphadenopathy
  • Head and neck lymphadenopathy
  • Hepatic lymphadenopathy
  • Hilar lymphadenopathy
  • Hypogastric lymphadenopathy
  • Hypoplastic lymph node
  • Ileocolic lymphadenopathy
  • Iliac lymphadenopathy
  • Inferior auricular lymphadenopathy
  • Inferior gluteal lymphadenopathy
  • Inferior inguinal lymphadenopathy
  • Inferior pancreatic lymphadenopathy
  • Inferior pancreaticoduodenal lymphadenopathy
  • Inferior tracheobronchial lymphadenopathy
  • Infraclavicular lymphadenopathy
  • Inguinal lymphadenopathy
  • Innominate lymphadenopathy
  • Intercostal lymphadenopathy
  • Interiliac lymphadenopathy
  • Intermediate common iliac lymphadenopathy
  • Intermediate external iliac lymphadenopathy
  • Intestinal lymphadenopathy
  • Jugular lymphadenopathy
  • Lateral axillary lymphadenopathy
  • Lateral cervical lymphadenopathy
  • Lateral common iliac lymphadenopathy
  • Lateral external iliac lymphadenopathy
  • Lateral pericardial lymphadenopathy
  • Lateral vesicular lymphadenopathy
  • Left colic lymphadenopathy
  • Left gastric lymphadenopathy
  • Localized enlarged lymph nodes
  • Lower extremity lymphadenopathy
  • Lumbar lymphadenopathy
  • Lymphadenopathy of epiploic foramen
  • Lymphadenopathy of greater curvature of stomach
  • Lymphadenopathy of head AND/OR neck
  • Lymphadenopathy of lesser curvature of stomach
  • Lymphadenopathy of lymph node ring of cardia of stomach
  • Lymphoid hyperplasia of stomach
  • Mandibular lymphadenopathy
  • Medial common iliac lymphadenopathy
  • Medial external iliac lymphadenopathy
  • Medial lacunar lymphadenopathy
  • Mediastinal lymphadenopathy
  • Midcolic lymphadenopathy
  • Obturator lymphadenopathy
  • Occipital lymphadenopathy
  • Pancreatic lymphadenopathy
  • Pancreaticoduodenal lymphadenopathy
  • Pancreaticosplenic lymphadenopathy
  • Paramammary lymphadenopathy
  • Parametrial lymphadenopathy
  • Pararectal lymphadenopathy
  • Parasternal lymphadenopathy
  • Paratracheal lymphadenopathy
  • Paravaginal lymphadenopathy
  • Paravesicular lymphadenopathy
  • Parotid lymphadenopathy
  • Pectoral axillary lymphadenopathy
  • Pelvic lymphadenopathy
  • Popliteal lymphadenopathy
  • Posterior auricular lymphadenopathy
  • Posterior mediastinal lymphadenopathy
  • Posterior tibial lymphadenopathy
  • Prececal lymphadenopathy
  • Prelaryngeal lymphadenopathy
  • Prepericardial lymphadenopathy
  • Presymphysial lymphadenopathy
  • Pretracheal lymphadenopathy
  • Prevertebral lymphadenopathy
  • Prevesicular lymphadenopathy
  • Promontory lymphadenopathy
  • Pulmonary lymphadenopathy
  • Pyloric lymphadenopathy
  • Regional lymphadenopathy caused by Bacillus of Calmette-Guérin
  • Renal hilar lymphadenopathy
  • Retrocecal lymphadenopathy
  • Retroperitoneal lymphadenopathy
  • Retropharyngeal lymphadenopathy
  • Retropyloric lymphadenopathy
  • Right colic lymphadenopathy
  • Sacral lymphadenopathy
  • Scalene lymphadenopathy
  • Signal node
  • Splenic lymphadenopathy
  • Subaortic common iliac lymphadenopathy
  • Submandibular lymphadenopathy
  • Submaxillary lymphadenopathy
  • Submental lymphadenopathy
  • Subpyloric lymphadenopathy
  • Subscapular axillary lymphadenopathy
  • Superficial inguinal lymphadenopathy
  • Superficial popliteal lymphadenopathy
  • Superior gluteal lymphadenopathy
  • Superior lateral inguinal lymphadenopathy
  • Superior medial inguinal lymphadenopathy
  • Superior pancreatic lymphadenopathy
  • Superior pancreaticoduodenal lymphadenopathy
  • Superior rectal lymphadenopathy
  • Superior tracheobronchial lymphadenopathy
  • Supraclavicular lymphadenopathy
  • Suprapyloric lymphadenopathy
  • Thoracic lymphadenopathy
  • Tibial lymphadenopathy
  • Tracheal lymphadenopathy
  • Tracheobronchial lymphadenopathy
  • Upper extremity lymphadenopathy
  • Uterine paracervical lymphadenopathy

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Adenopathy(lymph gland)
      • inguinal
    • Adenopathy(lymph gland)
      • localized
    • Adenopathy(lymph gland)
      • mediastinal
    • Adenopathy(lymph gland)
      • mesentery
    • Adenopathy(lymph gland)
      • tracheobronchial
    • Enlargement, enlarged
      • lymph gland or node
        • localized
    • Hyperplasia, hyperplastic
      • cervical gland
    • Hypertrophy, hypertrophic
      • gland, glandular
        • localized
    • Hypertrophy, hypertrophic
      • hilus gland
    • Hypertrophy, hypertrophic
      • lymph, lymphatic gland
        • localized
    • Lymphadenopathy(generalized)
      • localized
    • Swelling(of)
      • cervical gland
    • Swelling(of)
      • glands
        • localized

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM016
Other general signs and symptoms
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Cervical Lymphadenopathy

    enlargement of the cervical lymph nodes usually due to infections or involvement by malignant neoplasms.

Convert R59.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
785.6 Enlargement lymph nodes
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R59.0Overview

Is R59.0 (Enlarged lymph nodes) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report localized enlarged lymph nodes on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does R59.0 group to?

When localized enlarged lymph nodes is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.

Can R59.0 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the localized enlarged lymph nodes is established, that condition takes the principal position instead.

What is the ICD-9 equivalent of R59.0?

Under the General Equivalence Mappings, localized enlarged lymph nodes converts to ICD-9-CM 785.6 (enlargement lymph nodes). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.