R59.9 - Enlarged lymph nodes, unspecified

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

• Castleman disease
• Firm lymph node
• Fluctuant lymph node
• Hyperplastic lymph node
• Lymphoid hyperplasia
• Pulmonary venous hypertension due to compression of pulmonary great vein
• Pulmonary venous hypertension due to compression of pulmonary great vein by lymphadenopathy
• Shotty lymph node

Clinical Information

• Castleman Disease-. large benign, hyperplastic lymph nodes. the more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. plasma cells are often present and represent another subtype with the plasma cells containing igm and immunoglobulin a.
• Atypical Gastric Lymphoid Hyperplasia|Atypical Gastric Lymphoid Hyperplasia of Stomach|Atypical Gastric Lymphoid Hyperplasia of the Stomach-. an atypical lymphoid hyperplasia involving the gastric mucosa.
• Atypical Lymphoproliferative Disorder|Atypical Lymphoid Hyperplasia-. a lymphoproliferative disorder characterized by the presence of an atypical lymphocytic infiltrate.
• Benign Lymphoid Hyperplasia-. a polyclonal proliferation of lymphocytes without evidence of cytologic atypia.
• Castleman Disease, Hyaline-Vascular Type|Angiofollicular Lymphoid Hyperplasia, Hyaline-Vascular Type|Castleman's Disease, Hyaline-Vascular Type-. the commonest type of castleman disease. it is seen most commonly in the mediastinum. histologically this is characterized by hyalinized germinal centers surrounded by small lymphocytes in a concentric fashion, giving an onion skin appearance.
• Castleman Disease, Plasma Cell Type|Angiofollicular Lymphoid Hyperplasia, Plasma Cell Type|Castleman's Disease, Plasma Cell Type-. castleman disease characterized by the presence of prominent hyalinized vessels in the germinal centers and prominent sheets of plasma cells in the interfollicular areas.
• Castleman Disease|AFLH|Angiofollicular Lymphoid Hyperplasia|Castleman's Disease|Castleman's Tumor|Castleman's disease|GLNH|Giant Lymph Node Hyperplasia-. a disorder characterized by lymphoid hyperplasia in the lymph nodes. there are two histologic variants recognized: the hyaline-vascular type and the plasma cell type. in the hyaline vascular type there are hyalinized vessels present in the lymphoid follicles. in the plasma cell type there is pronounced plasma cell proliferation. clinically, the disease may be localized; manifested with localized lymphadenopathy, or multicentric; manifested with generalized lymphadenopathy, fever, organomegaly, and sometimes poems syndrome. in contrast to patients with localized disease who are usually cured following resection of the lesion, patients with the multicentric form of the disease may follow a progressive clinical course, complicated by infection, kaposi sarcoma or lymphoma.
• Cervical Florid Reactive Lymphoid Hyperplasia-. a dense, superficial benign lymphoid cell proliferation in the cervix. it almost always occurs in premenopausal women. it is composed of a mixture of large and small lymphocytes including immunoblasts. plasma cells and neutrophils are also present. immunohistochemical studies reveal a mixture of b and t lymphocytes, and polytypic plasma cells.
• Conjunctival Reactive Lymphoid Hyperplasia-. a polyclonal proliferation of lymphoid tissue in the conjunctiva that typically occurs in young adults. it usually presents as a unilateral, red or orange, painless swelling and is probably caused by chronic antigen stimulation. (who 2018)
• Epithelioid Hemangioma|Angiolymphoid Hyperplasia with Eosinophilia|Epithelioid hemangioma|Histiocytoid Hemangioma|Histiocytoid hemangioma-. a hemangioma characterized by the presence of epithelioid endothelial cells.
• Follicular Bronchitis/Bronchiolitis|Follicular Hyperplasia of BALT|Pulmonary Lymphoid Hyperplasia-. a non-neoplastic disorder characterized by the formation of reactive lymphoid follicles adjacent to distal bronchi and bronchioles. it presents with mild shortness of breath and is associated with immunodeficiency syndromes and collagen vascular disorders.
• Lacrimal Gland Reactive Lymphoid Hyperplasia-. a polyclonal proliferation of lymphoid tissue in the lacrimal gland. it usually presents as painless palpable masses leading to globe displacement, decreased motility, diplopia, and ptosis. it has a tendency to involve bilateral lacrimal glands. there is a higher incidence in females and in the setting of autoimmune disease. (who 2018)
• Localized Castleman Disease|Localized Angiofollicular Lymphoid Hyperplasia|Localized Angiofollicular Lymphoid Hyperplasia-. angiofollicular lymphoid hyperplasia that presents with localized lymphadenopathy.
• Lymphoid Hyperplasia-. a benign or malignant, diffuse and/or follicular lymphocytic proliferation.
• Multicentric Castleman Disease|Multicentric Angiofollicular Lymphoid Hyperplasia|Multicentric Angiofollicular Lymphoid Hyperplasia|Multicentric Castleman's Disease-. a form of angiofollicular lymphoid hyperplasia characterized by fever, generalized lymphadenopathy, hypergammaglobulinemia, and dysfunction of multiple organs. other signs and symptoms include anemia, thrombocytopenia, hepatomegaly, peripheral neuropathy and pleural effusions. morphologically, in the majority of cases the lymph nodes show features of angiofollicular lymphoid hyperplasia of the plasma cell type. in a minority of cases, changes of angiofollicular lymphoid hyperplasia of the hyaline-vascular type are seen. in contrast to patients with localized disease who are usually cured following resection of the lesion, patients with the multicentric form of the disease may follow a progressive clinical course, complicated by infection, kaposi sarcoma, or lymphoma.
• Nodular Lymphoid Hyperplasia of Lung-. a rare, reactive lesion in the lung parenchyma. it is characterized by the formation of a single or several nodules that are composed of lymphocytic infiltrates with reactive germinal centers.
• Primary Choroidal Non-Hodgkin Lymphoma|Choroidal Reactive Lymphoid Hyperplasia|Primary Choroidal Lymphoma-. an indolent, low-grade b-cell non-hodgkin lymphoma that arises from the choroid. it is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. lymphoid follicles with germinal centers may be present. in the past these tumors were termed 'reactive lymphoid hyperplasia'. now they are considered low-grade b-cell lymphomas, most commonly extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.
• Primary Uveal Non-Hodgkin Lymphoma|Primary Uveal Lymphoma|Uveal Reactive Lymphoid Hyperplasia-. an indolent, low-grade b-cell non-hodgkin lymphoma that arises from the choroid, iris, or ciliary body. it is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. lymphoid follicles with germinal centers may be present. in the past these tumors were termed 'reactive lymphoid hyperplasia'. now they are considered low-grade b-cell lymphomas, most commonly extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.
• Skin Epithelioid Hemangioma|Angiolymphoid Cutaneous Hyperplasia|Angiolymphoid Hyperplasia of Skin|Angiolymphoid Hyperplasia of the Skin|Epithelioid Hemangioma of Skin|Epithelioid Hemangioma of the Skin|Histiocytoid Hemangioma of Skin|Histiocytoid Hemangioma of the Skin-. a hemangioma arising from the skin. it is characterized by the presence of epithelioid endothelial cells.

Diagnostic Related Groups - MS-DRG Mapping

The is diagnosis code is grouped in the following groups for version MS-DRG V40.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC). applicable from 10/01/2022 through 09/30/2023.

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Patient Education

Lymphatic Diseases

The lymphatic system is a network of tissues and organs. It is made up of:

• Lymph - a fluid that contains white blood cells that defend against germs
• Lymph vessels - vessels that carry lymph throughout your body. They are different from blood vessels.
• Lymph nodes - glands found throughout the lymph vessels. Along with your spleen, these nodes are where white blood cells fight infection.

Your bone marrow and thymus produce the cells in lymph. They are part of the system, too.

The lymphatic system clears away infection and keeps your body fluids in balance. If it's not working properly, fluid builds in your tissues and causes swelling, called lymphedema. Other lymphatic system problems can include infections, blockage, and cancer.

Code History

• FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
• FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
• FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
• FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
• FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
• FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
• FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
• FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)