ICD-10-CM Code R59.1

Generalized enlarged lymph nodes

Version 2020 Billable Code No Valid Principal Dx

Valid for Submission

R59.1 is a billable code used to specify a medical diagnosis of generalized enlarged lymph nodes. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code R59.1 might also be used to specify conditions or terms like deep lymphadenopathy, fibrotic lymphadenopathy, finding of sensation of lymph node, generalized enlarged lymph nodes, lymphadenopathy, lymphadenopathy co-occurrent with human immunodeficiency virus infection, etc

According to ICD-10-CM guidelines this code should not to be used as a principal diagnosis code when a related definitive diagnosis has been established.

Short Description:Generalized enlarged lymph nodes
Long Description:Generalized enlarged lymph nodes

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code R59.1:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Lymphadenopathy NOS

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code R59.1 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Deep lymphadenopathy
  • Fibrotic lymphadenopathy
  • Finding of sensation of lymph node
  • Generalized enlarged lymph nodes
  • Lymphadenopathy
  • Lymphadenopathy co-occurrent with human immunodeficiency virus infection
  • O/E - lymph node character
  • O/E - lymph node character
  • O/E - lymph node character
  • O/E - lymph node character
  • O/E - lymph nodes
  • O/E - lymph nodes
  • O/E - lymph nodes
  • O/E - lymph nodes
  • O/E - lymph nodes firm
  • O/E - lymph nodes fluctuant
  • O/E - lymph nodes hard
  • O/E - lymph nodes tethered
  • Pain of lymph node
  • Pain of lymphoreticular structure
  • Paravesicular lymphadenopathy
  • Persistent generalized lymphadenopathy
  • Piringer-Kuchinka's syndrome
  • Postvesicular lymphadenopathy
  • Reactive lymphadenopathy
  • Superficial lymphadenopathy
  • Swelling of lymphoreticular structure
  • Tender lymph node
  • Tenderness of lymphoreticular structure

Diagnostic Related Groups

The ICD-10 code R59.1 is grouped in the following groups for version MS-DRG V37.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2020.


Convert R59.1 to ICD-9

  • 785.6 - Enlargement lymph nodes (Approximate Flag)

Code Classification

  • Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00–R99)
    • General symptoms and signs (R50-R69)
      • Enlarged lymph nodes (R59)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients

Lymphatic Diseases

The lymphatic system is a network of tissues and organs. It is made up of

  • Lymph - a fluid that contains white blood cells that defend against germs
  • Lymph vessels - vessels that carry lymph throughout your body. They are different from blood vessels.
  • Lymph nodes - glands found throughout the lymph vessels. Along with your spleen, these nodes are where white blood cells fight infection.

Your bone marrow and thymus produce the cells in lymph. They are part of the system, too.

The lymphatic system clears away infection and keeps your body fluids in balance. If it's not working properly, fluid builds in your tissues and causes swelling, called lymphedema. Other lymphatic system problems can include infections, blockage, and cancer.

[Learn More]