Version 2024
No Valid Principal Dx

2024 ICD-10-CM Diagnosis Code R59.1

Generalized enlarged lymph nodes

ICD-10-CM Code:
ICD-10 Code for:
Generalized enlarged lymph nodes
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
    • General symptoms and signs
      • Enlarged lymph nodes

R59.1 is a billable diagnosis code used to specify a medical diagnosis of generalized enlarged lymph nodes. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

According to ICD-10-CM guidelines this code should not to be used as a principal diagnosis code when a related definitive diagnosis has been established.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Deep lymphadenopathy
  • Fibrotic lymphadenopathy
  • Finding of lymph node
  • Generalized enlarged lymph nodes
  • Lymphadenopathy
  • Lymphadenopathy co-occurrent with human immunodeficiency virus infection
  • Paravesicular lymphadenopathy
  • Persistent generalized lymphadenopathy
  • Postvesicular lymphadenopathy
  • Reactive lymphadenopathy
  • Superficial lymphadenopathy
  • Swelling of lymphoreticular structure
  • Tender lymph node
  • Tenderness of lymphoreticular structure
  • Tethering of lymph node

Clinical Classification

Clinical Information

  • AIDS-Related Complex

    a prodromal phase of infection with the human immunodeficiency virus (hiv). laboratory criteria separating aids-related complex (arc) from aids include elevated or hyperactive b-cell humoral immune responses, compared to depressed or normal antibody reactivity in aids; follicular or mixed hyperplasia in arc lymph nodes, leading to lymphocyte degeneration and depletion more typical of aids; evolving succession of histopathological lesions such as localization of kaposi's sarcoma, signaling the transition to the full-blown aids.
  • HIV

    human immunodeficiency virus. a non-taxonomic and historical term referring to any of two species, specifically hiv-1 and/or hiv-2. prior to 1986, this was called human t-lymphotropic virus type iii/lymphadenopathy-associated virus (htlv-iii/lav). from 1986-1990, it was an official species called hiv. since 1991, hiv was no longer considered an official species name; the two species were designated hiv-1 and hiv-2.
  • HIV Antibodies

    antibodies reactive with hiv antigens.
  • HIV Antigens

    antigens associated with specific proteins of the human adult t-cell immunodeficiency virus (hiv); also called htlv-iii-associated and lymphadenopathy-associated virus (lav) antigens.
  • Immunoblastic Lymphadenopathy

    a disorder characterized by proliferation of arborizing small vessels, prominent immunoblastic proliferations and amorphous acidophilic interstitial material. clinical manifestations include fever, sweats, weight loss, generalized lymphadenopathy and frequently hepatosplenomegaly.
  • Lymphadenopathy

    disease of lymph nodes which are abnormal in size, number or consistency.
  • Spotted Fever Group Rickettsiosis

    a group of arthropod-borne diseases caused by spotted fever bio-group members of rickettsia. they are characterized by fever, headache, and petechial (spotted) rash.
  • Lymph Nodes

    they are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
  • Rickettsia

    a genus of gram-negative, aerobic, rod-shaped bacteria often surrounded by a protein microcapsular layer and slime layer. the natural cycle of its organisms generally involves a vertebrate and an invertebrate host. species of the genus are the etiological agents of human diseases, such as typhus.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Lymphadenopathy NOS

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert R59.1 to ICD-9-CM

  • ICD-9-CM Code: 785.6 - Enlargement lymph nodes
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.


[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.