2026 ICD-10-CM Diagnosis Code R50.2Drug induced fever

ICD-10-CM Codes›R00–R99›R50-R69›R50

ICD-10-CM R50.2
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R50.2 is a billable ICD-10-CM diagnosis code for drug induced fever. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. Coders also document this condition as drug-induced hyperpyrexia. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Fever.

Code Identity

ICD-10-CM Code
R50.2
Billable Status
Yes — Valid for Submission
Code Describes
Drug induced fever
Short Description
Drug induced fever
Same as the full description in the CMS dataset.
Parent Code
R50
Fever of other and unknown origin

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR50-R69General symptoms and signs
CategoryR50Fever of other and unknown origin
This CodeR50.2Drug induced fever

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Drug-induced hyperpyrexia
  • Hyperpyrexia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Use Additional Code

  • code for adverse effect, if applicable, to identify drug T36 T50

Type 1 Excludes

  • postvaccination postimmunization fever R50.83

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Drug
      • induced fever
    • Fever(inanition) (of unknown origin) (persistent) (with chills) (with rigor)
      • drug induced
    • Fever(inanition) (of unknown origin) (persistent) (with chills) (with rigor)
      • iodide
    • Fever(inanition) (of unknown origin) (persistent) (with chills) (with rigor)
      • steroid
    • Steroid
      • effects (adverse) (adrenocortical) (iatrogenic)
        • fever

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR SYM002
Fever
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • Hyperpyrexia

    body temperature of 106 degrees fahrenheit (41.1 degrees celsius) or higher.

  • Malignant Hyperthermia Syndrome|Malignant Hyperpyrexia|Malignant Hyperthermia|Malignant Hyperthermia

    a rare disorder characterized by rapid rise of the body temperature, accompanied by rhabdomyolysis and, if untreated, by collapse and death. it occurs in susceptible individuals who receive certain drugs for general anesthesia, gas anesthetics, or succinylcholine. it may be inherited in an autosomal dominant pattern.

Patient EducationClinical

Fever

A fever is a body temperature that is higher than normal. A normal temperature can vary from person to person, but it is usually around 98.6 °F (37 °C). A fever is not a disease. It is usually a sign that your body is trying to fight an illness or infection.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert R50.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
780.60 Fever NOS
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
E947.9 Adv eff medicinal NOS
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R50.2Overview

Is R50.2 (Fever of other and unknown origin) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report drug induced fever on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can R50.2 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the drug induced fever is established, that condition takes the principal position instead.

What is the ICD-9 equivalent of R50.2?

Under the General Equivalence Mappings, drug induced fever converts to ICD-9-CM 780.60 (fever NOS) and E947.9 (adv eff medicinal NOS). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.