2027 ICD-10-CM Diagnosis Code R45.1Restlessness and agitation
ICD-10-CM Codes›R00–R99›R40-R46›R45
- Billable — Valid for Submission
- Not Chronic
R45.1 is a billable ICD-10-CM diagnosis code for restlessness and agitation. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 884. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Symptoms of mental and substance use conditions.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Agitated wandering
- Aimless movement
- Aimless overactivity
- Constant movement
- Continuously shifting in seat
- Feeling agitated
- Fidgeting
- Pacing up and down
- Psychomotor agitation
- Reduced level of agitation
- Restlessness
- Restlessness and agitation
- Squirming
- Stress and adjustment reaction
- Stress reaction with psychomotor agitation
- Verbal agitation
- Wandering
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to R45.1: its own notes plus those printed at block R40-R46 and Chapter 18. A note printed at a category, block or chapter applies to every code under it.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Notes
General instructions on how these codes are used.
- This chapter includes symptoms, signs, abnormal results of clinical or other investigative procedures, and ill-defined conditions regarding which no diagnosis classifiable elsewhere is recorded.
- Signs and symptoms that point rather definitely to a given diagnosis have been assigned to a category in other chapters of the classification. In general, categories in this chapter include the less well-defined conditions and symptoms that, without the necessary study of the case to establish a final diagnosis, point perhaps equally to two or more diseases or to two or more systems of the body. Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'. The Alphabetical Index should be consulted to determine which symptoms and signs are to be allocated here and which to other chapters. The residual subcategories, numbered .8, are generally provided for other relevant symptoms that cannot be allocated elsewhere in the classification.
- The conditions and signs or symptoms included in categories R00-R94 consist of:
- (a) cases for which no more specific diagnosis can be made even after all the facts bearing on the case have been investigated;
- (b) signs or symptoms existing at the time of initial encounter that proved to be transient and whose causes could not be determined;
- (c) provisional diagnosis in a patient who failed to return for further investigation or care;
- (d) cases referred elsewhere for investigation or treatment before the diagnosis was made;
- (e) cases in which a more precise diagnosis was not available for any other reason;
- (f) certain symptoms, for which supplementary information is provided, that represent important problems in medical care in their own right.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name R45.1, its category, or a range that includes it.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Agitation R45.1
Restlessness R45.1
agitated R45.1
restlessness R45.1
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Psychomotor Agitation
a feeling of restlessness associated with increased motor activity. this may occur as a manifestation of nervous system drug toxicity or other conditions.
Patient EducationClinical
Anxiety
Anxiety is a feeling of fear, dread, and uneasiness. It might cause you to sweat, feel restless and tense, and have a rapid heartbeat. It can be a normal reaction to stress. For example, you might feel anxious when faced with a difficult problem at work, before taking a test, or before making an important decision.
The full article covers:
- What is anxiety?
- What are anxiety disorders?
- What are the types of anxiety disorders?
- What causes anxiety disorders?
- Who is at risk for anxiety disorders?
- What are the symptoms of anxiety disorders?
- How are anxiety disorders diagnosed?
- What are the treatments for anxiety disorders?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert R45.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About R45.1Overview
What is the ICD-10 code for restlessness and agitation?
The ICD-10-CM code for restlessness and agitation is R45.1 (sometimes written as R451). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is R45.1 (Symptoms and signs involving emotional state) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report restlessness and agitation on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does R45.1 group to?
When restlessness and agitation is the principal diagnosis on an inpatient stay, it groups to MS-DRG 884 (organic Disturbances and Intellectual Disability), which carries a relative weight of 1.5998. Higher weights mean higher Medicare reimbursement.
Can R45.1 be a principal diagnosis?
Use it with care. This is a symptom code, so once a definitive diagnosis explaining the restlessness and agitation is established, that condition takes the principal position instead.
What is the ICD-9 equivalent of R45.1?
Under the General Equivalence Mappings, restlessness and agitation converts to ICD-9-CM 307.9 (special symptom NEC/NOS). The mapping is approximate, so confirm the match fits the documentation.
