2026 ICD-10-CM Diagnosis Code R16.2Hepatomegaly with splenomegaly, not elsewhere classified

ICD-10-CM Codes›R00–R99›R10-R19›R16

ICD-10-CM R16.2
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R16.2 is a billable ICD-10-CM diagnosis code for hepatomegaly with splenomegaly, not elsewhere classified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 441 through 443. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. Coders also document this condition as cutaneous syndrome with ichthyosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Abdominal pain and other digestive/abdomen signs and symptoms.

Code Identity

ICD-10-CM Code
R16.2
Billable Status
Yes — Valid for Submission
Code Describes
Hepatomegaly with splenomegaly, not elsewhere classified
Short Description
Hepatomegaly with splenomegaly, not elsewhere classified
Same as the full description in the CMS dataset.
Parent Code
R16
Hepatomegaly and splenomegaly, not elsewhere classified

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR10-R19Symptoms and signs involving the digestive system and abdomen
CategoryR16Hepatomegaly and splenomegaly, not elsewhere classified
This CodeR16.2Hepatomegaly with splenomegaly, not elsewhere classified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Cutaneous syndrome with ichthyosis
  • Disorder of hematopoietic system in newborn
  • Hepatosplenomegaly
  • Ichthyosis, cerebellar degeneration and hepatosplenomegaly
  • Neonatal hepatosplenomegaly

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Hepatosplenomegaly NOS

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Hepatomegaly
      • with splenomegaly
    • Hepatosplenomegaly
    • Splenomegaly, splenomegalia(Bengal) (cryptogenic) (idiopathic) (tropical)
      • with hepatomegaly

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM006
Abdominal pain and other digestive/abdomen signs and symptoms
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hepatosplenomegaly

    an abnormal enlargement of both the liver and spleen.

Patient EducationClinical

Liver Diseases

Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert R16.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
789.1 Hepatomegaly
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
789.2 Splenomegaly
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R16.2Overview

Is R16.2 (Hepatomegaly and splenomegaly, not elsewhere classified) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hepatomegaly with splenomegaly, not elsewhere classified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does R16.2 group to?

When hepatomegaly with splenomegaly, not elsewhere classified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 441, 442, 443, with relative weights from 0.6997 to 1.7947 depending on complications. Higher weights mean higher Medicare reimbursement.

Can R16.2 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the hepatomegaly with splenomegaly, not elsewhere classified is established, that condition takes the principal position instead.

What is the ICD-9 equivalent of R16.2?

Under the General Equivalence Mappings, hepatomegaly with splenomegaly, not elsewhere classified converts to ICD-9-CM 789.1 (hepatomegaly) and 789.2 (splenomegaly). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.