Hepatomegaly and splenomegaly, not elsewhere classified (R16) ICD-10-CM
The R16 code range covers hepatomegaly and splenomegaly, not elsewhere classified with 4 ICD-10-CM diagnosis codes. 3 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Codes in the R16 Range 4 codes · 3 billable
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the R16 range.
Gaucher Disease
An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
Idiopathic Noncirrhotic Portal Hypertension
Portal hypertension without known risk factors for hypertension, e.g., HEPATIC CIRRHOSIS and SCHISTOSOMIASIS. Idiopathic Noncirrhotic Portal Hypertension is most often associated with pathology in the PORTAL SYSTEM vasculature.
Splenomegaly
Enlargement of the spleen.
About the R16 Code Range
ICD-10 code R16 and its subcodes identify conditions involving enlargement of the liver and/or spleen that are not classified elsewhere. These codes are used when a patient presents with an enlarged liver (hepatomegaly), an enlarged spleen (splenomegaly), or both, without a more specific underlying diagnosis available in other code categories.
The section includes R16.0 for hepatomegaly, also known by terms like "liver palpable" or "large liver," encompassing conditions such as liver enlargement in AIDS or schistosomal liver disease. R16.1 covers splenomegaly, linked with synonyms like "spleen palpable" and related infections or storage diseases causing spleen enlargement. When both liver and spleen are enlarged together, R16.2 applies; this includes conditions described as "hepatosplenomegaly" or neonatal disorders involving both organs. These codes guide coders and healthcare professionals in documenting and billing for cases where organ enlargement is noted but lacks more detailed categorization in ICD-10, facilitating accurate capture of clinical findings.
Questions About This Page
How many billable codes are in the R16 range?
Of the 4 codes in this range, 3 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the R16 range classify?
The range classifies hepatomegaly and splenomegaly, not elsewhere classified. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
