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  2. ICD-10-CM Codes List
  3. R00–R99
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  5. Hepatomegaly and splenomegaly, not elsewhere classified (R16)

Hepatomegaly and splenomegaly, not elsewhere classified (R16)

ICD-10 code R16 and its subcodes identify conditions involving enlargement of the liver and/or spleen that are not classified elsewhere. These codes are used when a patient presents with an enlarged liver (hepatomegaly), an enlarged spleen (splenomegaly), or both, without a more specific underlying diagnosis available in other code categories.

The section includes R16.0 for hepatomegaly, also known by terms like "liver palpable" or "large liver," encompassing conditions such as liver enlargement in AIDS or schistosomal liver disease. R16.1 covers splenomegaly, linked with synonyms like "spleen palpable" and related infections or storage diseases causing spleen enlargement. When both liver and spleen are enlarged together, R16.2 applies; this includes conditions described as "hepatosplenomegaly" or neonatal disorders involving both organs. These codes guide coders and healthcare professionals in documenting and billing for cases where organ enlargement is noted but lacks more detailed categorization in ICD-10, facilitating accurate capture of clinical findings.

Clinical Terms

The following clinical terms provide additional context, helping users better understand the clinical background and common associations for each diagnosis listed in this section. Including related terms alongside ICD-10-CM codes supports coders, billers, and healthcare professionals in improving accuracy, enhancing documentation, and facilitating research or patient education.

Gaucher Disease

An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.

Idiopathic Noncirrhotic Portal Hypertension

Portal hypertension without known risk factors for hypertension, e.g., HEPATIC CIRRHOSIS and SCHISTOSOMIASIS. Idiopathic Noncirrhotic Portal Hypertension is most often associated with pathology in the PORTAL SYSTEM vasculature.

Splenomegaly

Enlargement of the spleen.