2026 ICD-10-CM Diagnosis Code L81.4Other melanin hyperpigmentation

AHRQ’s CCSR groups this code into broader clinical categories.

• Melanosis

  disorders of increased melanin pigmentation that develop without preceding inflammatory disease.

• Acquired Benign Epithelial Melanosis of the Conjunctiva

  benign epithelial melanosis of the conjunctiva that is not present at birth.

• Benign Epithelial Melanosis of the Conjunctiva|Complexion-Related Melanosis|Constitutional Melanosis

  a benign melanocytic lesion that arises from the conjunctiva and is characterized by the presence of increased melanin pigmentation within the conjunctival melanocytes. atypical features such as mitotic activity, nuclear enlargement, and prominent nucleoli are absent. it is usually bilateral and is frequently seen in people with fitzpatrick skin types iv -vi. in white populations the occurrence is low. the prognosis is very good and malignant transformation to melanocytic intraepithelial neoplasia and/or melanoma is very rare.

• Congenital Benign Epithelial Melanosis of the Conjunctiva

  benign epithelial melanosis of the conjunctiva that is present at birth.

• Guttate Hypomelanosis|Guttate hypomelanosis

  a benign skin condition characterized by white or whitish spots or patches on sun-exposed areas of the skin due to decreased melanin production.

• Becker Nevus|Becker's Nevus|Linear Papular Ectodermal-Mesodermal Hamartoma|Melanosis Neviformis|Pigmented Hairy Epidermal Nevus|Pigmented Hairy Nevus of Becker|Progressive Cribriform and Zosteriform Hyperpigmentation

  a benign lesion that is sometimes congenital and consists of an overgrowth of the epidermis and the presence of melanin-containing cells. it is found mostly in males and typically develops during childhood or adolescence, becoming darker and more hairy after puberty.

• Conjunctival Melanocytic Intraepithelial Lesion|C-MIL|C-MIN|Conjunctival Melanocytic Intraepithelial Neoplasia|Conjunctival Primary Acquired Melanosis with Atypia|PAM with Atypia|Primary Acquired Melanosis with Atypia

  a spectrum of neoplastic changes that occur in the conjunctiva and range from melanocytic hyperplasia through degrees of atypia to melanoma in situ. the lesions are generally unilateral but often multifocal and appear as flat, irregular brown discolorations of the conjunctiva. they usually affect middle-aged and elderly caucasians. (who 2018)

• High Grade Conjunctival Melanocytic Intraepithelial Lesion|High Grade C-MIL|High-Grade C-MIL|High-Grade Conjunctival Melanocytic Intraepithelial Lesion|PAM with Moderate to Severe Atypia|Primary Acquired Melanosis with Moderate to Severe Atypia

  conjunctival melanocytic intraepithelial lesion characterized by the presence of moderate to severe atypia.

• Intraepithelial Melanocytic Hyperplasia|Benign Acquired Melanosis

  a hyperplasia of the intraepithelial melanocytes.

• Low Grade Conjunctival Melanocytic Intraepithelial Lesion|Low Grade C-MIL|Low-Grade C-MIL|Low-Grade Conjunctival Melanocytic Intraepithelial Lesion|PAM with Mild Atypia|Primary Acquired Melanosis with Mild Atypia

  conjunctival melanocytic intraepithelial lesion characterized by the presence of mild atypia.

• Melanoma in Precancerous Melanosis|Malignant Cutaneous (Skin) Melanoma in Precancerous Melanosis|Malignant Melanoma in Precancerous Melanosis|Malignant melanoma in precancerous melanosis

  a melanoma arising from an atypical intraepithelial melanocytic hyperplasia.

• Melanosis

  a benign congenital or acquired lesion that arises from mucosal sites and is characterized by melanin pigment deposition in the basilar keratinocytes. it may be associated with a slight proliferation of junctional melanocytes. it presents as a single or multiple pigmented macules or patches in the external genitalia, anorectal region, distal urinary tract, and oral cavity.

• Meningeal Melanocytosis|Diffuse Melanocytosis|Diffuse Melanosis|Diffuse Meningeal Melanocytosis|Diffuse melanocytosis

  a diffuse or multifocal proliferation of uniform nevoid polygonal cells in the leptomeninges. cells may spread into the virchow-robin spaces without frank invasion of the brain. diffuse melanocytosis carries a poor prognosis even in the absence of histologic malignancy. (who)

• Neurocutaneous Melanosis|NCM|Neurocutaneous Melanocytosis

  a congenital condition characterized by the presence of giant and/or multiple satellite congenital melanocytic nevi in the skin and benign melanocytic pigmentation of the leptomeninges.

• Nevus of Ito|Hypomelanosis of Ito|Ito's Nevus

  a large brown, blue, or gray hamartoma of dermal melanocytes, usually on the shoulder and upper arm that is most commonly found in asian populations and in females. it is sometimes associated with sensory changes in the involved skin area, but very rarely becomes cancerous.

• Ocular Melanocytosis|Melanosis Oculi

  a congenital abnormality characterized by the presence of an increased population of non-proliferating hyperpigmented melanocytes in the sclera, iris, ciliary body, choroid, and orbit. patients present with hyperchromic heterochromia.

• Racial Melanosis|BCEM|Benign Conjunctival Epithelial Melanosis|CAM|Complexion-Associated Melanosis|Conjunctival Hypermelanosis|Primary Conjunctival Hypermelanosis

  a benign conjunctival finding noted especially among darker pigmented individuals. while it is typically found perilimbally and bilaterally, it can also cover the conjunctivae extensively and may present asymmetrically. the flat, non-cystic pigmentation may increase in size with age. it is rare to have this finding evolve into conjunctival melanoma.

• Transient Neonatal Pustular Melanosis

  a benign, self-limited eruption of vesicles, pustules and macules seen in newborns. the fluid-filled lesions typically rupture and resolve within 48 hours while the macular lesions may persist for months.

Skin Pigmentation Disorders

Pigmentation means coloring. Skin pigmentation disorders affect the color of your skin. Your skin gets its color from a pigment called melanin. Special cells in the skin make melanin. When these cells become damaged or unhealthy, it affects melanin production. Some pigmentation disorders affect just patches of skin.

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