2026 ICD-10-CM Diagnosis Code E74.10Disorder of fructose metabolism, unspecified

ICD-10-CM Codes›E00–E89›E70-E88›E74

ICD-10-CM E74.10
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E74.10 is a billable ICD-10-CM diagnosis code for disorder of fructose metabolism, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 391 through 392. Coders also document this condition as acquired intolerance to fructose. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E74.10
Billable Status
Yes — Valid for Submission
Code Describes
Disorder of fructose metabolism, unspecified
Short Description
Disorder of fructose metabolism, unspecified
Same as the full description in the CMS dataset.
Parent Code
E74.1
Disorders of fructose metabolism

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE74Other disorders of carbohydrate metabolism
This CodeE74.10Disorder of fructose metabolism, unspecified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired intolerance to fructose
  • Fructose metabolism disorder
  • Malabsorption syndrome due to acquired intolerance to fructose

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Disorder(of)
      • fructose metabolism
    • Disorder(of)
      • metabolism NOS
        • fructose
    • Disturbance(s)
      • fructose metabolism
    • Intolerance
      • fructose

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Carbohydrate Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E74.10 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
271.2 Hered fructose intoleran
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E74.10Overview

Is E74.10 (Disorders of fructose metabolism) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report disorder of fructose metabolism, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E74.10 group to?

When disorder of fructose metabolism, unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 391, 392, with relative weights from 0.7796 to 1.2683 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E74.10?

Under the General Equivalence Mappings, disorder of fructose metabolism, unspecified converts to ICD-9-CM 271.2 (hered fructose intoleran). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.