MS-DRG · FY 2026 v43.0

MS-DRG 391 – Esophagitis, Gastroenteritis and Miscellaneous Digestive Disorders with MCC

A Medical DRG in MDC 06 (Diseases & Disorders of the Digestive System). Inpatient cases group to DRG 391 when the ICD-10-CM principal diagnosis is one of the 250 codes listed below and a secondary diagnosis on the major complication or comorbidity (MCC) list is present. Its FY 2026 relative weight is 1.2683 with a geometric mean length of stay of 3.8 days.

Medical DRG – assigned by principal diagnosis✓ Official CMS v43.0 dataset
1.2683
Relative Weight
3.8
Geometric Mean LOS (days)
5.1
Arithmetic Mean LOS (days)
250
Principal Diagnosis Codes

Severity family

DRG 391with MCCWeight 1.2683 · GMLOS 3.8 daysDRG 392without MCCWeight 0.7796 · GMLOS 2.5 days
How a case is assigned to DRG 391

The grouper first assigns the case to MDC 06 from the principal diagnosis and finds no qualifying operating-room procedure (this is a Medical DRG; ICD-10-PCS codes do not drive assignment here), then applies the severity split from secondary diagnoses: with MCC → 391; without MCC → 392.

ICD-10-CM

Principal Diagnosis Codes 250 codes · 40 categories

250 of 250 shown
A05 Other bacterial foodborne intoxications, not elsewhere classified1 code
  • A05.9 Bacterial foodborne intoxication, unspecified
A08 Viral and other specified intestinal infections9 codes
  • A08.0 Rotaviral enteritis
  • A08.11 Acute gastroenteropathy due to Norwalk agent
  • A08.19 Acute gastroenteropathy due to other small round viruses
  • A08.2 Adenoviral enteritis
  • A08.31 Calicivirus enteritis
  • A08.32 Astrovirus enteritis
  • A08.39 Other viral enteritis
  • A08.4 Viral intestinal infection, unspecified
  • A08.8 Other specified intestinal infections
A09 Infectious gastroenteritis and colitis, unspecified1 code
  • A09 Infectious gastroenteritis and colitis, unspecified
B37 Candidiasis1 code
B68 Taeniasis3 codes
  • B68.0 Taenia solium taeniasis
  • B68.1 Taenia saginata taeniasis
  • B68.9 Taeniasis, unspecified
B70 Diphyllobothriasis and sparganosis1 code
B77 Ascariasis4 codes
  • B77.0 Ascariasis with intestinal complications
  • B77.81 Ascariasis pneumonia
  • B77.89 Ascariasis with other complications
  • B77.9 Ascariasis, unspecified
B78 Strongyloidiasis3 codes
  • B78.0 Intestinal strongyloidiasis
  • B78.7 Disseminated strongyloidiasis
  • B78.9 Strongyloidiasis, unspecified
B79 Trichuriasis1 code
  • B79 Trichuriasis
B80 Enterobiasis1 code
  • B80 Enterobiasis
B81 Other intestinal helminthiases, not elsewhere classified5 codes
  • B81.0 Anisakiasis
  • B81.1 Intestinal capillariasis
  • B81.2 Trichostrongyliasis
  • B81.3 Intestinal angiostrongyliasis
  • B81.8 Other specified intestinal helminthiases
B82 Unspecified intestinal parasitism2 codes
  • B82.0 Intestinal helminthiasis, unspecified
  • B82.9 Intestinal parasitism, unspecified
D18 Hemangioma and lymphangioma, any site1 code
  • D18.03 Hemangioma of intra-abdominal structures
E73 Lactose intolerance4 codes
  • E73.0 Congenital lactase deficiency
  • E73.1 Secondary lactase deficiency
  • E73.8 Other lactose intolerance
  • E73.9 Lactose intolerance, unspecified
E74 Other disorders of carbohydrate metabolism6 codes
  • E74.10 Disorder of fructose metabolism, unspecified
  • E74.11 Essential fructosuria
  • E74.12 Hereditary fructose intolerance
  • E74.19 Other disorders of fructose metabolism
  • E74.31 Sucrase-isomaltase deficiency
  • E74.39 Other disorders of intestinal carbohydrate absorption
I77 Other disorders of arteries and arterioles1 code
  • I77.4 Celiac artery compression syndrome
K20 Esophagitis3 codes
  • K20.0 Eosinophilic esophagitis
  • K20.80 Other esophagitis without bleeding
  • K20.90 Esophagitis, unspecified without bleeding
K21 Gastro-esophageal reflux disease2 codes
  • K21.00 Gastro-esophageal reflux disease with esophagitis, without bleeding
  • K21.9 Gastro-esophageal reflux disease without esophagitis
K22 Other diseases of esophagus8 codes
  • K22.0 Achalasia of cardia
  • K22.2 Esophageal obstruction
  • K22.4 Dyskinesia of esophagus
  • K22.5 Diverticulum of esophagus, acquired
  • K22.81 Esophageal polyp
  • K22.82 Esophagogastric junction polyp
  • K22.89 Other specified disease of esophagus
  • K22.9 Disease of esophagus, unspecified
K23 Disorders of esophagus in diseases classified elsewhere1 code
  • K23 Disorders of esophagus in diseases classified elsewhere
K29 Gastritis and duodenitis9 codes
  • K29.00 Acute gastritis without bleeding
  • K29.20 Alcoholic gastritis without bleeding
  • K29.30 Chronic superficial gastritis without bleeding
  • K29.40 Chronic atrophic gastritis without bleeding
  • K29.50 Unspecified chronic gastritis without bleeding
  • K29.60 Other gastritis without bleeding
  • K29.70 Gastritis, unspecified, without bleeding
  • K29.80 Duodenitis without bleeding
  • K29.90 Gastroduodenitis, unspecified, without bleeding
K30 Functional dyspepsia1 code
  • K30 Functional dyspepsia
K31 Other diseases of stomach and duodenum20 codes
  • K31.0 Acute dilatation of stomach
  • K31.2 Hourglass stricture and stenosis of stomach
  • K31.3 Pylorospasm, not elsewhere classified
  • K31.4 Gastric diverticulum
  • K31.6 Fistula of stomach and duodenum
  • K31.819 Angiodysplasia of stomach and duodenum without bleeding
  • K31.83 Achlorhydria
  • K31.84 Gastroparesis
  • K31.89 Other diseases of stomach and duodenum
  • K31.9 Disease of stomach and duodenum, unspecified
  • K31.A0 Gastric intestinal metaplasia, unspecified
  • K31.A11 Gastric intestinal metaplasia without dysplasia, involving the antrum
  • K31.A12 Gastric intestinal metaplasia without dysplasia, involving the body (corpus)
  • K31.A13 Gastric intestinal metaplasia without dysplasia, involving the fundus
  • K31.A14 Gastric intestinal metaplasia without dysplasia, involving the cardia
  • K31.A15 Gastric intestinal metaplasia without dysplasia, involving multiple sites
  • K31.A19 Gastric intestinal metaplasia without dysplasia, unspecified site
  • K31.A21 Gastric intestinal metaplasia with low grade dysplasia
  • K31.A22 Gastric intestinal metaplasia with high grade dysplasia
  • K31.A29 Gastric intestinal metaplasia with dysplasia, unspecified
K44 Diaphragmatic hernia2 codes
  • K44.0 Diaphragmatic hernia with obstruction, without gangrene
  • K44.9 Diaphragmatic hernia without obstruction or gangrene
K52 Other and unspecified noninfective gastroenteritis and colitis12 codes
  • K52.21 Food protein-induced enterocolitis syndrome
  • K52.22 Food protein-induced enteropathy
  • K52.29 Other allergic and dietetic gastroenteritis and colitis
  • K52.3 Indeterminate colitis
  • K52.81 Eosinophilic gastritis or gastroenteritis
  • K52.82 Eosinophilic colitis
  • K52.831 Collagenous colitis
  • K52.832 Lymphocytic colitis
  • K52.838 Other microscopic colitis
  • K52.839 Microscopic colitis, unspecified
  • K52.89 Other specified noninfective gastroenteritis and colitis
  • K52.9 Noninfective gastroenteritis and colitis, unspecified
K57 Diverticular disease of intestine12 codes
  • K57.00 Diverticulitis of small intestine with perforation and abscess without bleeding
  • K57.10 Diverticulosis of small intestine without perforation or abscess without bleeding
  • K57.12 Diverticulitis of small intestine without perforation or abscess without bleeding
  • K57.20 Diverticulitis of large intestine with perforation and abscess without bleeding
  • K57.30 Diverticulosis of large intestine without perforation or abscess without bleeding
  • K57.32 Diverticulitis of large intestine without perforation or abscess without bleeding
  • K57.40 Diverticulitis of both small and large intestine with perforation and abscess without bleeding
  • K57.50 Diverticulosis of both small and large intestine without perforation or abscess without bleeding
  • K57.52 Diverticulitis of both small and large intestine without perforation or abscess without bleeding
  • K57.80 Diverticulitis of intestine, part unspecified, with perforation and abscess without bleeding
  • K57.90 Diverticulosis of intestine, part unspecified, without perforation or abscess without bleeding
  • K57.92 Diverticulitis of intestine, part unspecified, without perforation or abscess without bleeding
K58 Irritable bowel syndrome5 codes
  • K58.0 Irritable bowel syndrome with diarrhea
  • K58.1 Irritable bowel syndrome with constipation
  • K58.2 Mixed irritable bowel syndrome
  • K58.8 Other irritable bowel syndrome
  • K58.9 Irritable bowel syndrome, unspecified
K59 Other functional intestinal disorders12 codes
  • K59.00 Constipation, unspecified
  • K59.01 Slow transit constipation
  • K59.02 Outlet dysfunction constipation
  • K59.03 Drug induced constipation
  • K59.04 Chronic idiopathic constipation
  • K59.09 Other constipation
  • K59.1 Functional diarrhea
  • K59.2 Neurogenic bowel, not elsewhere classified
  • K59.4 Anal spasm
  • K59.81 Ogilvie syndrome
  • K59.89 Other specified functional intestinal disorders
  • K59.9 Functional intestinal disorder, unspecified
K90 Intestinal malabsorption12 codes
  • K90.0 Celiac disease
  • K90.1 Tropical sprue
  • K90.2 Blind loop syndrome, not elsewhere classified
  • K90.3 Pancreatic steatorrhea
  • K90.41 Non-celiac gluten sensitivity
  • K90.49 Malabsorption due to intolerance, not elsewhere classified
  • K90.821 Short bowel syndrome with colon in continuity
  • K90.822 Short bowel syndrome without colon in continuity
  • K90.829 Short bowel syndrome, unspecified
  • K90.83 Intestinal failure
  • K90.89 Other intestinal malabsorption
  • K90.9 Intestinal malabsorption, unspecified
K91 Intraoperative and postprocedural complications and disorders of digestive system, not elsewhere classified3 codes
  • K91.0 Vomiting following gastrointestinal surgery
  • K91.1 Postgastric surgery syndromes
  • K91.2 Postsurgical malabsorption, not elsewhere classified
K92 Other diseases of digestive system1 code
  • K92.81 Gastrointestinal mucositis (ulcerative)
N80 Endometriosis19 codes
  • N80.50 Endometriosis of intestine, unspecified
  • N80.511 Superficial endometriosis of the rectum
  • N80.512 Deep endometriosis of the rectum
  • N80.519 Endometriosis of the rectum, unspecified depth
  • N80.521 Superficial endometriosis of the sigmoid colon
  • N80.522 Deep endometriosis of the sigmoid colon
  • N80.529 Endometriosis of the sigmoid colon, unspecified depth
  • N80.531 Superficial endometriosis of the cecum
  • N80.532 Deep endometriosis of the cecum
  • N80.539 Endometriosis of the cecum, unspecified depth
  • N80.541 Superficial endometriosis of the appendix
  • N80.542 Deep endometriosis of the appendix
  • N80.549 Endometriosis of the appendix, unspecified depth
  • N80.551 Superficial endometriosis of other parts of the colon
  • N80.552 Deep endometriosis of other parts of the colon
  • N80.559 Endometriosis of other parts of the colon, unspecified depth
  • N80.561 Superficial endometriosis of the small intestine
  • N80.562 Deep endometriosis of the small intestine
  • N80.569 Endometriosis of the small intestine, unspecified depth
R10 Abdominal and pelvic pain42 codes
  • R10.0 Acute abdomen
  • R10.10 Upper abdominal pain, unspecified
  • R10.11 Right upper quadrant pain
  • R10.12 Left upper quadrant pain
  • R10.13 Epigastric pain
  • R10.20 Pelvic and perineal pain unspecified side
  • R10.21 Pelvic and perineal pain right side
  • R10.22 Pelvic and perineal pain left side
  • R10.23 Pelvic and perineal pain bilateral
  • R10.24 Suprapubic pain
  • R10.30 Lower abdominal pain, unspecified
  • R10.31 Right lower quadrant pain
  • R10.32 Left lower quadrant pain
  • R10.33 Periumbilical pain
  • R10.811 Right upper quadrant abdominal tenderness
  • R10.812 Left upper quadrant abdominal tenderness
  • R10.813 Right lower quadrant abdominal tenderness
  • R10.814 Left lower quadrant abdominal tenderness
  • R10.815 Periumbilic abdominal tenderness
  • R10.816 Epigastric abdominal tenderness
  • R10.817 Generalized abdominal tenderness
  • R10.819 Abdominal tenderness, unspecified site
  • R10.821 Right upper quadrant rebound abdominal tenderness
  • R10.822 Left upper quadrant rebound abdominal tenderness
  • R10.823 Right lower quadrant rebound abdominal tenderness
  • R10.824 Left lower quadrant rebound abdominal tenderness
  • R10.825 Periumbilic rebound abdominal tenderness
  • R10.826 Epigastric rebound abdominal tenderness
  • R10.827 Generalized rebound abdominal tenderness
  • R10.829 Rebound abdominal tenderness, unspecified site
  • R10.83 Colic
  • R10.84 Generalized abdominal pain
  • R10.85 Abdominal pain of multiple sites
  • R10.8A1 Right flank tenderness
  • R10.8A2 Left flank tenderness
  • R10.8A3 Suprapubic tenderness
  • R10.8A9 Flank tenderness, unspecified
  • R10.9 Unspecified abdominal pain
  • R10.A0 Flank pain, unspecified side
  • R10.A1 Flank pain, right side
  • R10.A2 Flank pain, left side
  • R10.A3 Flank pain, bilateral
R11 Nausea and vomiting7 codes
R12 Heartburn1 code
R13 Aphagia and dysphagia7 codes
  • R13.0 Aphagia
  • R13.10 Dysphagia, unspecified
  • R13.11 Dysphagia, oral phase
  • R13.12 Dysphagia, oropharyngeal phase
  • R13.13 Dysphagia, pharyngeal phase
  • R13.14 Dysphagia, pharyngoesophageal phase
  • R13.19 Other dysphagia
R14 Flatulence and related conditions4 codes
R15 Fecal incontinence4 codes
R19 Other symptoms and signs involving the digestive system and abdomen17 codes
  • R19.00 Intra-abdominal and pelvic swelling, mass and lump, unspecified site
  • R19.01 Right upper quadrant abdominal swelling, mass and lump
  • R19.02 Left upper quadrant abdominal swelling, mass and lump
  • R19.03 Right lower quadrant abdominal swelling, mass and lump
  • R19.04 Left lower quadrant abdominal swelling, mass and lump
  • R19.05 Periumbilic swelling, mass or lump
  • R19.06 Epigastric swelling, mass or lump
  • R19.07 Generalized intra-abdominal and pelvic swelling, mass and lump
  • R19.09 Other intra-abdominal and pelvic swelling, mass and lump
  • R19.11 Absent bowel sounds
  • R19.12 Hyperactive bowel sounds
  • R19.15 Other abnormal bowel sounds
  • R19.2 Visible peristalsis
  • R19.4 Change in bowel habit
  • R19.5 Other fecal abnormalities
  • R19.7 Diarrhea, unspecified
  • R19.8 Other specified symptoms and signs involving the digestive system and abdomen
R93 Abnormal findings on diagnostic imaging of other body structures2 codes
  • R93.3 Abnormal findings on diagnostic imaging of other parts of digestive tract
  • R93.5 Abnormal findings on diagnostic imaging of other abdominal regions, including retroperitoneum
ICD-10-PCS

Procedure Codes

Procedure codes do not drive assignment for this DRG. DRG 391 is a Medical DRG, assigned from the principal diagnosis above.

Frequently Asked Questions

What is MS-DRG 391?

MS-DRG 391 (Esophagitis, Gastroenteritis and Miscellaneous Digestive Disorders with MCC) is a medical DRG in MDC 06 (Diseases & Disorders of the Digestive System). Its FY 2026 relative weight is 1.2683 with a geometric mean length of stay of 3.8 days.

What is the difference between DRG 391, 392?

All 2 share the same base category; the severity of secondary diagnoses separates them: 391 (with MCC), 392 (without MCC). A major complication or comorbidity (MCC) places the case in the highest-weighted DRG of the family; a CC in the middle; neither in the lowest.

How many diagnosis codes group to DRG 391?

250 ICD-10-CM principal diagnosis codes group to this DRG, spanning 40 three-character categories.

What is the relative weight of DRG 391?

The FY 2026 relative weight of this DRG is 1.2683, meaning reimbursement of roughly 1.27 times the average Medicare inpatient case. Multiply by a hospital's blended base rate for the approximate payment.

← PreviousDRG 390 – Gastrointestinal Obstruction without CC/MCC
Source: CMS ICD-10 MS-DRG v43.0 Definitions Manual and the FY 2026 IPPS Final Rule (Table 5), effective October 1, 2025 through September 30, 2026. We publish the DRG assignments as CMS defines them and add the navigation, search, and code links.