2026 ICD-10-CM Diagnosis Code D84.89Other immunodeficiencies
ICD-10-CM Codes›D50–D89›D80-D89›D84
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Chronic Condition
D84.89 is a billable ICD-10-CM diagnosis code for other immunodeficiencies. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 44 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.
D84.89 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 47 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 47, ESRD (V21) category 47, ESRD (V24) category 47, and RxHCC Part D (V08) category 99 for payment year 2026.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D84.89 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Absent thumb with short stature and immunodeficiency syndrome
- Activated PI3K-delta syndrome
- Adult-onset immunodeficiency
- Adult-onset immunodeficiency with anti-interferon-gamma autoantibodies
- Age-related immunodeficiency
- Aplasia of thumb
- Autoimmune leukopenia
- Autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 1 deficiency
- Autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency
- Autosomal recessive mendelian susceptibility to mycobacterial disease due to complete RORgamma receptor mutation
- Autosomal recessive mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 1 deficiency
- Autosomal recessive mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency
- Autosomal recessive mendelian susceptibility to mycobacterial disease due to partial JAK1 deficiency
- Autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity
- CD4 T lymphocyte deficiency
- CEBPE-associated autoinflammation, immunodeficiency, neutrophil dysfunction syndrome
- Cellular immune defect
- Congenital immunodeficiency involving the hematopoietic system
- Congenital progressive bone marrow failure, B-cell immunodeficiency, skeletal dysplasia syndrome
- Constitutional mismatch repair deficiency syndrome
- Constitutional mismatch repair deficiency syndrome due to PMS2 mutation
- Cryopyrin associated periodic syndrome
- Defective immunoglobulin glycosylation
- Defective phagocytic cell opsonization
- Early-onset autoimmunity, autoinflammation, immunodeficiency syndrome due to SOCS1 haploinsufficiency
- FADD-related immunodeficiency
- Familial cold urticaria
- Familial hyperinflammatory lymphoproliferative immunodeficiency
- Griscelli syndrome type 1
- Griscelli syndrome type 3
- Heritable disorder of neutrophil function
- Hypopigmentation-immunodeficiency disease
- IL21-related infantile inflammatory bowel disease
- Immune defect
- Immune dysregulation, inflammatory bowel disease, arthritis, recurrent infection, lymphopenia syndrome
- Immunodeficiency associated with multiple organ system abnormalities
- Immunodeficiency due to CD25 deficiency
- Immunodeficiency due to ficolin 3 deficiency
- Immunodeficiency with major anomalies
- Immunoglobulin-associated molecule deficiency
- Immuno-osseous dysplasia
- Interleukin-12 deficiency
- Lichtenstein syndrome
- Lymphocyte count below reference range
- Lymphocytopenia
- Mannan-binding protein deficiency
- Mannose-binding lectin deficiency
- MDA5 deficiency
- Mendelian susceptibility to mycobacterial disease
- Mendelian susceptibility to mycobacterial disease due to complete interferon gamma receptor 2 deficiency
- Mendelian susceptibility to mycobacterial disease due to complete ISG15 deficiency
- Mendelian susceptibility to mycobacterial disease due to partial IRF8 deficiency
- Mendelian susceptibility to mycobacterial disease due to partial STAT1 deficiency
- Myelodysplastic syndrome with low blasts
- Natural-killer cell deficiency
- Neutrophil immunodeficiency syndrome
- Phagocytic immunodeficiency
- PLCG2-associated antibody deficiency and immune dysregulation
- Predisposition to invasive fungal disease due to CARD9 deficiency
- Predisposition to severe viral infection due to IRF7 deficiency
- Predominantly T-cell defect
- Pyogenic bacterial infection due to MyD88 deficiency
- Schimke immuno-osseous dysplasia
- Secretory piece deficiency
- Skeletal dysplasia, T-cell immunodeficiency, developmental delay syndrome
- Susceptibility to infection due to TYK2 deficiency
- T lymphocyte disorder
- T-cell immunodeficiency with epidermodysplasia verruciformis
- T-lymphocyte deficiency
- T-lymphocyte immunodeficiency
- Transient immunodeficiency of infancy
- Urticaria caused by cold
- Warts, immunodeficiency, lymphedema, anogenital dysplasia syndrome
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Code History & ChangesHistory
Replacement D84.89 replaces the following previously assigned code(s):
- D84.8 - Other specified immunodeficiencies
Questions About D84.89Overview
What is the ICD-10 code for other immunodeficiencies?
The ICD-10-CM code for other immunodeficiencies is D84.89 (sometimes written as D8489). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is D84.89 (Other specified immunodeficiencies) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other immunodeficiencies on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D84.89 group to?
When other immunodeficiencies is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.
Is D84.89 a CC or MCC?
CMS lists D84.89 as a CC (complication or comorbidity) for FY 2026. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 44 closely related codes in its exclusion list.
Does D84.89 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. D84.89 mapped to HCC 47 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 47 (Disorders of Immunity), ESRD (V21) category 47 (Disorders of Immunity), ESRD (V24) category 47 (Disorders of Immunity), and RxHCC Part D (V08) category 99 (Immune Disorders).
