2026 ICD-10-CM Diagnosis Code D84.89Other immunodeficiencies

ICD-10-CM Codes›D50–D89›D80-D89›D84

ICD-10-CM D84.89
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D84.89 is a billable ICD-10-CM diagnosis code for other immunodeficiencies. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.

Code Identity

ICD-10-CM Code
D84.89
Billable Status
Yes — Valid for Submission
Code Describes
Other immunodeficiencies
Short Description
Other immunodeficiencies
Same as the full description in the CMS dataset.
Parent Code
D84.8
Other specified immunodeficiencies

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD80-D89Certain disorders involving the immune mechanism
CategoryD84Other immunodeficiencies
This CodeD84.89Other immunodeficiencies

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Absent thumb with short stature and immunodeficiency syndrome
  • Activated PI3K-delta syndrome
  • Adult-onset immunodeficiency
  • Adult-onset immunodeficiency with anti-interferon-gamma autoantibodies
  • Age-related immunodeficiency
  • Aplasia of thumb
  • Autoimmune leukopenia
  • Autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 1 deficiency
  • Autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency
  • Autosomal recessive mendelian susceptibility to mycobacterial disease due to complete RORgamma receptor mutation
  • Autosomal recessive mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 1 deficiency
  • Autosomal recessive mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency
  • Autosomal recessive mendelian susceptibility to mycobacterial disease due to partial JAK1 deficiency
  • Autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity
  • CD4 T lymphocyte deficiency
  • CEBPE-associated autoinflammation, immunodeficiency, neutrophil dysfunction syndrome
  • Cellular immune defect
  • Congenital immunodeficiency involving the hematopoietic system
  • Congenital progressive bone marrow failure, B-cell immunodeficiency, skeletal dysplasia syndrome
  • Constitutional mismatch repair deficiency syndrome
  • Constitutional mismatch repair deficiency syndrome due to PMS2 mutation
  • Cryopyrin associated periodic syndrome
  • Defective immunoglobulin glycosylation
  • Defective phagocytic cell opsonization
  • Early-onset autoimmunity, autoinflammation, immunodeficiency syndrome due to SOCS1 haploinsufficiency
  • FADD-related immunodeficiency
  • Familial cold urticaria
  • Familial hyperinflammatory lymphoproliferative immunodeficiency
  • Griscelli syndrome type 1
  • Griscelli syndrome type 3
  • Heritable disorder of neutrophil function
  • Hypopigmentation-immunodeficiency disease
  • IL21-related infantile inflammatory bowel disease
  • Immune defect
  • Immune dysregulation, inflammatory bowel disease, arthritis, recurrent infection, lymphopenia syndrome
  • Immunodeficiency associated with multiple organ system abnormalities
  • Immunodeficiency due to CD25 deficiency
  • Immunodeficiency due to ficolin 3 deficiency
  • Immunodeficiency with major anomalies
  • Immunoglobulin-associated molecule deficiency
  • Immuno-osseous dysplasia
  • Interleukin-12 deficiency
  • Lichtenstein syndrome
  • Lymphocyte count below reference range
  • Lymphocytopenia
  • Mannan-binding protein deficiency
  • Mannose-binding lectin deficiency
  • MDA5 deficiency
  • Mendelian susceptibility to mycobacterial disease
  • Mendelian susceptibility to mycobacterial disease due to complete interferon gamma receptor 2 deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete ISG15 deficiency
  • Mendelian susceptibility to mycobacterial disease due to partial IRF8 deficiency
  • Mendelian susceptibility to mycobacterial disease due to partial STAT1 deficiency
  • Myelodysplastic syndrome with low blasts
  • Natural-killer cell deficiency
  • Neutrophil immunodeficiency syndrome
  • Phagocytic immunodeficiency
  • PLCG2-associated antibody deficiency and immune dysregulation
  • Predisposition to invasive fungal disease due to CARD9 deficiency
  • Predisposition to severe viral infection due to IRF7 deficiency
  • Predominantly T-cell defect
  • Pyogenic bacterial infection due to MyD88 deficiency
  • Schimke immuno-osseous dysplasia
  • Secretory piece deficiency
  • Skeletal dysplasia, T-cell immunodeficiency, developmental delay syndrome
  • Susceptibility to infection due to TYK2 deficiency
  • T lymphocyte disorder
  • T-cell immunodeficiency with epidermodysplasia verruciformis
  • T-lymphocyte deficiency
  • T-lymphocyte immunodeficiency
  • Transient immunodeficiency of infancy
  • Urticaria caused by cold
  • Warts, immunodeficiency, lymphedema, anogenital dysplasia syndrome

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Deficiency, deficient
      • immunity
        • cell-mediated
    • Immunodeficiency
      • specified type NEC

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD008
Immunity disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Code History & ChangesHistory

Replacement D84.89 replaces the following previously assigned code(s):

  • D84.8 - Other specified immunodeficiencies
FY 2021AddedAdded to the ICD-10-CM code setEffective October 1, 2020.
FY 2022–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D84.89Overview

Is D84.89 (Other specified immunodeficiencies) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other immunodeficiencies on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D84.89 group to?

When other immunodeficiencies is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.