2026 ICD-10-CM Diagnosis Code D72.810Lymphocytopenia

ICD-10-CM Codes›D50–D89›D70-D77›D72

ICD-10-CM D72.810
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D72.810 is a billable ICD-10-CM diagnosis code for lymphocytopenia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diseases of white blood cells.

Code Identity

ICD-10-CM Code
D72.810
Billable Status
Yes — Valid for Submission
Code Describes
Lymphocytopenia
Short Description
Lymphocytopenia
Same as the full description in the CMS dataset.
Parent Code
D72.81
Decreased white blood cell count

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD70-D77Other disorders of blood and blood-forming organs
CategoryD72Other disorders of white blood cells
This CodeD72.810Lymphocytopenia

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Abnormal lymphocyte destruction
  • Acquired lymphocytopenia
  • Autoimmune leukopenia
  • CD4 T lymphocyte deficiency
  • Cellular immune defect
  • Decreased lymphocyte production
  • Episodic lymphocytopenia
  • Idiopathic CD4 lymphocytopenia
  • Immune defect
  • Immune dysregulation, inflammatory bowel disease, arthritis, recurrent infection, lymphopenia syndrome
  • Lymphocyte abnormality
  • Lymphocyte count below reference range
  • Lymphocyte depletion
  • Lymphocyte finding
  • Lymphocytopenia
  • Lymphocytopenia due to COVID-19
  • Lymphopenia due to infection
  • Neonatal lymphocytopenia
  • Non-malignant lymphocyte AND/OR plasma cell disorder
  • T lymphocyte disorder
  • T-lymphocyte deficiency

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Decreased lymphocytes

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Alymphocytosis
    • Decrease(d)
      • lymphocytes
    • Lymphocytopenia
    • Lymphopenia

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD007
Diseases of white blood cells
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hodgkin Disease

    a malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. in the classical variant, giant usually multinucleate hodgkin's and reed-sternberg cells are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.

  • Lymphocyte Depletion

    immunosuppression by reduction of circulating lymphocytes or by t-cell depletion of bone marrow. the former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. the latter is performed ex vivo on bone marrow before its transplantation.

  • Reed-Sternberg Cells

    large cells, usually multinucleate, whose presence is a common histologic characteristic of classical hodgkin disease.

Patient EducationClinical

Blood Disorders

Your blood is living tissue made up of liquid and solids. The liquid part, called plasma, is made of water, salts and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells and platelets.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D72.810 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
288.51 Lymphocytopenia
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D72.810Overview

Is D72.810 (Decreased white blood cell count) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report lymphocytopenia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D72.810 group to?

When lymphocytopenia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D72.810?

Under the General Equivalence Mappings, lymphocytopenia converts to ICD-9-CM 288.51 (lymphocytopenia). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.