2026 ICD-10-CM Diagnosis Code D57.454Sickle-cell thalassemia beta plus with dactylitis

ICD-10-CM Codes›D50–D89›D55-D59›D57

ICD-10-CM D57.454
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D57.454 is a billable ICD-10-CM diagnosis code for sickle-cell thalassemia beta plus with dactylitis. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Sickle cell trait/anemia.

Code Identity

ICD-10-CM Code
D57.454
Billable Status
Yes — Valid for Submission
Code Describes
Sickle-cell thalassemia beta plus with dactylitis
Short Description
Sickle-cell thalassemia beta plus with dactylitis
Same as the full description in the CMS dataset.
Parent Code
D57.45
Sickle-cell thalassemia beta plus with crisis

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD57Sickle-cell disorders
This CodeD57.454Sickle-cell thalassemia beta plus with dactylitis

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Dactylitis
      • sickle-cell
        • Beta plus
    • Disease, diseased
      • hemoglobin or Hb
        • S or SS
          • beta plus
            • with
              • crisis
                • with
                  • dactylitis
    • Disease, diseased
      • sickle-cell
        • thalassemia
          • beta plus
            • with
              • acute chest syndrome
                • with dactylitis
    • Disease, diseased
      • sickle-cell
        • thalassemia
          • beta plus
            • with
              • dactylitis

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD005
Sickle cell trait/anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Code History & ChangesHistory

Replacement D57.454 replaces the following previously assigned code(s):

  • D57.458 - Sickle-cell thalassemia beta plus with crisis with oth comp
FY 2024AddedAdded to the ICD-10-CM code setEffective October 1, 2023.
FY 2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D57.454Overview

Is D57.454 (Sickle-cell thalassemia beta plus with crisis) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report sickle-cell thalassemia beta plus with dactylitis on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D57.454 group to?

When sickle-cell thalassemia beta plus with dactylitis is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.