2026 ICD-10-CM Diagnosis Code D53.1Other megaloblastic anemias, not elsewhere classified

ICD-10-CM Codes›D50–D89›D50-D53›D53

ICD-10-CM D53.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D53.1 is a billable ICD-10-CM diagnosis code for other megaloblastic anemias, not elsewhere classified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Nutritional anemia.

Code Identity

ICD-10-CM Code
D53.1
Billable Status
Yes — Valid for Submission
Code Describes
Other megaloblastic anemias, not elsewhere classified
Short Description
Other megaloblastic anemias, not elsewhere classified
Same as the full description in the CMS dataset.
Parent Code
D53
Other nutritional anemias

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD50-D53Nutritional anemias
CategoryD53Other nutritional anemias
This CodeD53.1Other megaloblastic anemias, not elsewhere classified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acute megaloblastic anemia
  • Acute megaloblastic anemia caused by nitrous oxide
  • Acute megaloblastic anemia due to dialysis
  • Acute megaloblastic anemia due to severe illness
  • Acute megaloblastic anemia secondary to total parenteral nutrition
  • Alcohol induced disorder co-occurrent and due to alcohol dependence
  • Anemia due to multiple mechanisms
  • Anemia in mother complicating pregnancy, childbirth AND/OR puerperium
  • Anemia of pregnancy
  • Combined B12 and folate deficiency anemia
  • Combined deficiency anemia
  • Cystic fibrosis with gastritis and megaloblastic anemia syndrome
  • Diabetes mellitus associated with genetic syndrome
  • Dimorphic anemia
  • Diphyllobothriasis
  • Gastritis caused by Helicobacter
  • Helicobacter pylori-associated gastritis
  • Juvenile type megaloblastic anemia
  • Megaloblastic anemia
  • Megaloblastic anemia caused by drugs
  • Megaloblastic anemia caused by fish tapeworm
  • Megaloblastic anemia due to alcoholism
  • Megaloblastic anemia due to blind loop syndrome
  • Megaloblastic anemia due to celiac disease
  • Megaloblastic anemia due to chronic hemolytic anemia
  • Megaloblastic anemia due to decreased intake of vitamin B>12<
  • Megaloblastic anemia due to dihydrofolate reductase deficiency
  • Megaloblastic anemia due to disease of small intestine
  • Megaloblastic anemia due to error of cobalamin metabolism
  • Megaloblastic anemia due to exfoliative dermatitis
  • Megaloblastic anemia due to gastrectomy
  • Megaloblastic anemia due to hemodialysis
  • Megaloblastic anemia due to hyperalimentation
  • Megaloblastic anemia due to impaired absorption of folate
  • Megaloblastic anemia due to inborn errors of metabolism
  • Megaloblastic anemia due to increased requirements
  • Megaloblastic anemia due to pancreatic insufficiency
  • Megaloblastic anemia due to pregnancy
  • Megaloblastic anemia due to tropical sprue
  • Megaloblastic anemia due to vitamin B>12< deficiency
  • Megaloblastic anemia due to Zollinger-Ellison syndrome
  • Megaloblastic anemia, thiamine-responsive, with diabetes mellitus and sensorineural deafness
  • Megaloblastic erythropoiesis
  • Pernicious anemia
  • RBC's - megaloblasts
  • Red blood cell maturation age - finding
  • Refractory megaloblastic anemia
  • Thiamine-responsive megaloblastic anemia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Megaloblastic anemia NOS

Type 1 Excludes

  • Di Guglielmo's disease C94.0

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • achrestic
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • deficiency
        • combined B12 and folate
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • dimorphic
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • diphasic
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • megaloblastic
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • megaloblastic
        • combined B12 and folate deficiency
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • megaloblastic
        • refractory
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • megaloblastic
        • specified type NEC
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • megalocytic
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • refractory
        • megaloblastic
    • Megalocytic anemia

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD001
Nutritional anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Diphyllobothriasis

    infection with tapeworms of the genus diphyllobothrium.

  • Diphyllobothriasis

    an infection that is caused by the tapeworm diphyllobothrium latum and related species; it is transmitted via consumption of raw or undercooked fish, and symptoms include abdominal discomfort, diarrhea, vomiting, fatigue, weight loss, and vitamin b12 deficiency.

  • Arakawa Syndrome II|Arakawa's Syndrome 2|Arakawa's Syndrome II|Homocystinuria-Megaloblastic Anemia, cblG Complementation Type|Methionine Synthase Deficiency|Methylcobalamin Deficiency, cblG Type|Tetrahydrofolate Methyltransferase Deficiency|Tetrahydrofolate Methyltransferase Deficiency

    a rare autosomal dominant inherited metabolic disorder characterized by deficiency of the enzyme tetrahydrofolate-methyltransferase. it results in the abnormal metabolism of methylcobalamin. signs and symptoms include mental retardation, megaloblastic anemia, hypotonia, epilepsy, and hepatosplenomegaly.

  • Homocystinuria-Megaloblastic Anemia, cblE Complementation Type|HMAE|Methylcobalamin Deficiency, cblE Type

    an autosomal recessive condition caused by mutation(s) in the mtrr gene, encoding methionine synthase reductase. it is characterized by homocystinuria and megaloblastic anemia.

  • Megaloblastic Anemia

    anemia characterized by the presence of unusually large erythroblasts in the bone marrow called megaloblasts. it is usually caused by vitamin b12 or folic acid deficiency. other causes include toxins and drugs.

  • Megaloblastic Anemia 1|Imerslund-Gräsbeck Syndrome|Juvenile Megaloblastic Anemia|MGA-1

    an autosomal recessive disorder caused by mutations in the cubn or amn genes. it is characterized by vitamin b12 deficiency due to selective malabsorption of the vitamin, and usually results in megaloblastic anemia appearing in childhood (but not immediately after birth).

  • Other Megaloblastic Anemias, not Elsewhere Classified|Other megaloblastic anemias, not elsewhere classified

    evidence of other megaloblastic anemias, not elsewhere classified not specified elsewhere.

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D53.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
281.3 Megaloblastic anemia NEC
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D53.1Overview

Is D53.1 (Other nutritional anemias) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other megaloblastic anemias, not elsewhere classified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D53.1 group to?

When other megaloblastic anemias, not elsewhere classified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D53.1?

Under the General Equivalence Mappings, other megaloblastic anemias, not elsewhere classified converts to ICD-9-CM 281.3 (megaloblastic anemia NEC). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.