2026 ICD-10-CM Diagnosis Code D52.1Drug-induced folate deficiency anemia

ICD-10-CM Codes›D50–D89›D50-D53›D52

ICD-10-CM D52.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D52.1 is a billable ICD-10-CM diagnosis code for drug-induced folate deficiency anemia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. Coders also document this condition as folate deficiency anemia, drug-induced. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Nutritional anemia.

Code Identity

ICD-10-CM Code
D52.1
Billable Status
Yes — Valid for Submission
Code Describes
Drug-induced folate deficiency anemia
Short Description
Drug-induced folate deficiency anemia
Same as the full description in the CMS dataset.
Parent Code
D52
Folate deficiency anemia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD50-D53Nutritional anemias
CategoryD52Folate deficiency anemia
This CodeD52.1Drug-induced folate deficiency anemia

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Folate deficiency anemia, drug-induced

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Use Additional Code

  • code for adverse effect, if applicable, to identify drug T36 T50

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • deficiency
        • folate
          • drug-induced
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • deficiency
        • folic acid
          • drug-induced
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • due to (in) (with)
        • deficiency
          • folate (folic acid)
            • drug-induced

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR BLD001
Nutritional anemia
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D52.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
281.2 Folate-deficiency anemia
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D52.1Overview

Is D52.1 (Folate deficiency anemia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report drug-induced folate deficiency anemia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D52.1 group to?

When drug-induced folate deficiency anemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D52.1?

Under the General Equivalence Mappings, drug-induced folate deficiency anemia converts to ICD-9-CM 281.2 (folate-deficiency anemia). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.