2027 ICD-10-CM Diagnosis Code C54.1Malignant neoplasm of endometrium
ICD-10-CM Codes›C00–D49›C51-C58›C54
- Billable — Valid for Submission
- Risk Adjusts — HCC 23
- Chronic Condition
C54.1 is a billable ICD-10-CM diagnosis code for malignant neoplasm of endometrium. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 731 through 733, 754 through 756. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Female reproductive system cancers - endometrium.
For Medicare Advantage risk adjustment, C54.1 maps to CMS-HCC Category 23 (Prostate, Breast, and Other Cancers and Tumors) under the V28 model, adding a risk factor of about 0.186 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
C54.1 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Abnormal uterine bleeding due to endometrial disorder
- Abnormal uterine bleeding due to primary malignant neoplasm of endometrium
- Adenocarcinoma of endometrium
- Carcinosarcoma of corpus uteri
- Carcinosarcoma of uterus
- Complex mixed and stromal malignant neoplasm of endometrium of corpus uteri
- Endometrial carcinoma
- Endometrial carcinosarcoma
- Endometrial stromal tumor
- Endometrioid carcinoma of endometrium
- High grade endometrial stromal sarcoma
- High-grade neuroendocrine carcinoma of corpus uteri
- Low grade endometrial stromal sarcoma
- Malignant neoplasm involving left fallopian tube by direct extension from endometrium
- Malignant neoplasm involving right fallopian tube by direct extension from endometrium
- Malignant neoplasm involving urinary bladder by direct extension from endometrium
- Malignant neoplasm of endometrium of corpus uteri
- Malignant tumor involving an organ by direct extension from endometrium
- Malignant tumor involving left ovary by direct extension from endometrium
- Malignant tumor involving rectum by direct extension from endometrium
- Malignant tumor involving right ovary by direct extension from endometrium
- Malignant tumor involving vagina by direct extension from endometrium
- Malignant tumor involving vulva by direct extension from endometrium
- Metastatic endometrial stromal sarcoma
- Primary adenosquamous carcinoma of endometrium
- Primary adenosquamous cell carcinoma
- Primary carcinosarcoma of corpus uteri
- Primary carcinosarcoma of uterus
- Primary endometrial carcinosarcoma
- Primary endometrioid carcinoma of endometrium
- Primary malignant clear cell neoplasm of endometrium
- Primary malignant neoplasm of endometrium
- Primary malignant neuroendocrine neoplasm of uterus
- Primary malignant stromal sarcoma of endometrium
- Primary mixed adenocarcinoma of endometrium
- Primary mucinous adenocarcinoma of endometrium
- Primary rhabdomyosarcoma of abdomen
- Primary rhabdomyosarcoma of endometrium of corpus uteri
- Primary rhabdomyosarcoma of pelvis
- Primary serous adenocarcinoma of endometrium
- Primary small cell neuroendocrine carcinoma of endometrium
- Primary squamous cell carcinoma of endometrium
- Primary undifferentiated carcinoma of body of uterus
- Primary undifferentiated carcinoma of endometrium
- Rhabdomyosarcoma of corpus uteri
- Rhabdomyosarcoma of endometrium of corpus uteri
- Sarcoma of endometrium
- Serous carcinoma of body of uterus
- Squamous cell carcinoma of corpus uteri
- Undifferentiated carcinoma of corpus uteri
- Undifferentiated carcinoma of endometrium
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to C54.1: its own notes plus those printed at block C51-C58 and Chapter 2. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- malignant neoplasm of skin of female genital organs
Notes
General instructions on how these codes are used.
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name C54.1, its category, or a range that includes it.
Applicable To 2
These notes mention C54.1.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Sarcoma (of) See Also: Neoplasm, connective tissue, malignant;
endometrial (stromal) C54.1
stromal (endometrial) C54.1
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Malignant Endometrial Neoplasm
primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity).
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
Patient EducationClinical
Uterine Cancer
Uterine cancer is a cancer that forms in tissues of the uterus, which is sometimes called the womb. The uterus is the place where a fetus grows during pregnancy.
The full article covers:
- What is uterine cancer?
- Who is more likely to develop uterine cancer?
- What are the symptoms of uterine cancer?
- How is uterine cancer diagnosed?
- What are the treatments for uterine cancer?
- Can uterine cancer be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert C54.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About C54.1Overview
What is the ICD-10 code for malignant neoplasm of endometrium?
The ICD-10-CM code for malignant neoplasm of endometrium is C54.1 (sometimes written as C541). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is C54.1 (Malignant neoplasm of corpus uteri) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report malignant neoplasm of endometrium on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does C54.1 group to?
When malignant neoplasm of endometrium is the principal diagnosis on an inpatient stay, it groups to MS-DRG 732, 755, 756, 754, 733, 731, with relative weights from 0.8583 to 3.5462 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of C54.1?
Under the General Equivalence Mappings, malignant neoplasm of endometrium converts to ICD-9-CM 182.0 (malig neo corpus uteri). The mapping is approximate, so confirm the match fits the documentation.
What HCC is C54.1?
C54.1 (malignant neoplasm of endometrium) maps to CMS-HCC Category 23 (Prostate, Breast, and Other Cancers and Tumors), commonly written as HCC 23, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 12 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. It does not map to any RxHCC in the Part D prescription drug model.
Does C54.1 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, C54.1 adds a risk adjustment factor of about 0.186 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.186 to 0.237 depending on the payment segment). A more severe related category (HCC 17, HCC 18, HCC 19, HCC 20, HCC 21, and HCC 22) supersedes it when both are reported. See the full factor table on the HCC 23 category page.
