2026 ICD-10-CM Diagnosis Code C54.1Malignant neoplasm of endometrium

ICD-10-CM Codes›C00–D49›C51-C58›C54

ICD-10-CM C54.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

C54.1 is a billable ICD-10-CM diagnosis code for malignant neoplasm of endometrium. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 736 through 741, 754 through 756. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Female reproductive system cancers - endometrium.

Code Identity

ICD-10-CM Code
C54.1
Billable Status
Yes — Valid for Submission
Code Describes
Malignant neoplasm of endometrium
Short Description
Malignant neoplasm of endometrium
Same as the full description in the CMS dataset.
Parent Code
C54
Malignant neoplasm of corpus uteri

Code Classification

ChapterC00–D49Neoplasms
SectionC51-C58Malignant neoplasms of female genital organs
CategoryC54Malignant neoplasm of corpus uteri
This CodeC54.1Malignant neoplasm of endometrium

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Abnormal uterine bleeding due to endometrial disorder
  • Abnormal uterine bleeding due to primary malignant neoplasm of endometrium
  • Adenocarcinoma of endometrium
  • Carcinosarcoma of corpus uteri
  • Carcinosarcoma of uterus
  • Complex mixed and stromal malignant neoplasm of endometrium of corpus uteri
  • Endometrial carcinoma
  • Endometrial carcinosarcoma
  • Endometrial stromal tumor
  • Endometrioid carcinoma of endometrium
  • High grade endometrial stromal sarcoma
  • High-grade neuroendocrine carcinoma of corpus uteri
  • Low grade endometrial stromal sarcoma
  • Malignant neoplasm involving left fallopian tube by direct extension from endometrium
  • Malignant neoplasm involving right fallopian tube by direct extension from endometrium
  • Malignant neoplasm involving urinary bladder by direct extension from endometrium
  • Malignant neoplasm of endometrium of corpus uteri
  • Malignant tumor involving an organ by direct extension from endometrium
  • Malignant tumor involving left ovary by direct extension from endometrium
  • Malignant tumor involving rectum by direct extension from endometrium
  • Malignant tumor involving right ovary by direct extension from endometrium
  • Malignant tumor involving vagina by direct extension from endometrium
  • Malignant tumor involving vulva by direct extension from endometrium
  • Metastatic endometrial stromal sarcoma
  • Primary adenosquamous carcinoma of endometrium
  • Primary adenosquamous cell carcinoma
  • Primary carcinosarcoma of corpus uteri
  • Primary carcinosarcoma of uterus
  • Primary endometrial carcinosarcoma
  • Primary endometrioid carcinoma of endometrium
  • Primary malignant clear cell neoplasm of endometrium
  • Primary malignant neoplasm of endometrium
  • Primary malignant neuroendocrine neoplasm of uterus
  • Primary malignant stromal sarcoma of endometrium
  • Primary mixed adenocarcinoma of endometrium
  • Primary mucinous adenocarcinoma of endometrium
  • Primary rhabdomyosarcoma of abdomen
  • Primary rhabdomyosarcoma of endometrium of corpus uteri
  • Primary rhabdomyosarcoma of pelvis
  • Primary serous adenocarcinoma of endometrium
  • Primary small cell neuroendocrine carcinoma of endometrium
  • Primary squamous cell carcinoma of endometrium
  • Primary undifferentiated carcinoma of body of uterus
  • Primary undifferentiated carcinoma of endometrium
  • Rhabdomyosarcoma of corpus uteri
  • Rhabdomyosarcoma of endometrium of corpus uteri
  • Sarcoma of endometrium
  • Serous carcinoma of body of uterus
  • Squamous cell carcinoma of corpus uteri
  • Undifferentiated carcinoma of corpus uteri
  • Undifferentiated carcinoma of endometrium

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Sarcoma(of)
      • endometrial (stromal)
    • Sarcoma(of)
      • stromal (endometrial)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO035
Female reproductive system cancers - endometrium
Default principal diagnosis: inpatient Yes · outpatient Yes

Table of NeoplasmsClinical

Anatomical sites in the Table of Neoplasms that reference this code family.

SiteMalig.
Primary		Malig.
Secondary		Ca
in situ		BenignUncertainUnspec.
endometrium (gland) (stroma)C54.1C79.82D07.0D26.1D39.0D49.59
stroma, endometrialC54.1C79.82D07.0D26.1D39.0D49.59
uterus, uteri, uterine › endometriumC54.1C79.82D07.0D26.1D39.0D49.59

Patient EducationClinical

Uterine Cancer

Uterine cancer is a cancer that forms in tissues of the uterus, which is sometimes called the womb. The uterus is the place where a fetus grows during pregnancy.

The full article covers:

  • What is uterine cancer?
  • Who is more likely to develop uterine cancer?
  • What are the symptoms of uterine cancer?
  • How is uterine cancer diagnosed?
  • What are the treatments for uterine cancer?
  • Can uterine cancer be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert C54.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
182.0 Malig neo corpus uteri
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About C54.1Overview

Is C54.1 (Malignant neoplasm of corpus uteri) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report malignant neoplasm of endometrium on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does C54.1 group to?

When malignant neoplasm of endometrium is the principal diagnosis on an inpatient stay, it groups to MS-DRG 736, 737, 738, 739, 740, 741, 754, 755, 756, with relative weights from 0.9605 to 3.5745 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of C54.1?

Under the General Equivalence Mappings, malignant neoplasm of endometrium converts to ICD-9-CM 182.0 (malig neo corpus uteri). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.