2027 ICD-10-CM Diagnosis Code B16.0Acute hepatitis B with delta-agent with hepatic coma
ICD-10-CM Codes›A00–B99›B15-B19›B16
- Billable — Valid for Submission
- MCC — Major Complication or Comorbidity
- Not Chronic
B16.0 is a billable ICD-10-CM diagnosis code for acute hepatitis B with delta-agent with hepatic coma. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 441 through 443, 791, 793. As a secondary diagnosis, it counts as a major complication or comorbidity (MCC) and places an inpatient stay in the highest severity level of its MS-DRG family. It does not count, however, when the principal diagnosis is one of 40 closely related codes. Coders also document this condition as hepatic coma due to acute hepatitis B. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Coma; stupor; and brain damage, Hepatitis, and Viral infection.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Hepatic coma due to acute hepatitis B
- Hepatic coma due to acute hepatitis B with delta agent
- Hepatic coma due to viral hepatitis
- Hepatic coma due to viral hepatitis B
- Hepatic coma due to viral hepatitis D
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to B16.0: its own notes plus those printed at block B15-B19 and Chapter 1. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- diseases generally recognized as communicable or transmissible
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- sequelae of viral hepatitis (B94.2)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- carrier or suspected carrier of infectious disease (Z22.-)
- certain localized infections - see body system-related chapters
- infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
- infectious and parasitic diseases specific to the perinatal period (P35-P39)
- influenza and other acute respiratory infections (J00-J22)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- code to identify resistance to antimicrobial drugs (Z16.-)
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name B16.0, its category, or a range that includes it.
Applicable To 1
These notes mention B16.0.
- O98.4 Viral hepatitis complicating pregnancy, childbirth and the puerperium
Excludes1 4
These codes carry an Excludes1 note naming B16.0: they are not reported together with it, unless the two conditions are unrelated.
Excludes2 3
These codes carry an Excludes2 note naming B16.0: its condition is not part of those codes, and both may be reported when the patient has both.
- Block K70-K77 Diseases of liver
- K72 Hepatic failure, not elsewhere classified
- T80.6 Other serum reactions
Code First 1
These codes say to code first a condition named in the note, and B16.0 is one of the conditions named.
- M02 Postinfective and reactive arthropathies
Use Additional Code 1
These codes say to use an additional code from the note, and B16.0 is one of the codes named.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Acute Hepatitis B Infection
a new infection by the hepatitis b virus, which can be transmitted by direct contact of infected blood with mucous membranes or open areas of the skin. signs and symptoms may include loss of appetite, joint and muscle pain, low-grade fever and stomach pain. two to six percent of adults progress to a chronic infection, while 90% of infants become chronically ill. a vaccine is available for those at risk.
Patient EducationClinical
Coma
A coma is a deep state of unconsciousness. An individual in a coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as brain injury.
Read the full article at MedlinePlus
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Convert B16.0 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About B16.0Overview
What is the ICD-10 code for acute hepatitis B with delta-agent with hepatic coma?
The ICD-10-CM code for acute hepatitis B with delta-agent with hepatic coma is B16.0 (sometimes written as B160). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is B16.0 (Acute hepatitis B) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report acute hepatitis B with delta-agent with hepatic coma on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does B16.0 group to?
When acute hepatitis B with delta-agent with hepatic coma is the principal diagnosis on an inpatient stay, it groups to MS-DRG 793, 791, 442, 441, 443, with relative weights from 0.6890 to 4.2192 depending on complications. Higher weights mean higher Medicare reimbursement.
Is B16.0 a CC or MCC?
CMS lists B16.0 as an MCC (major complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it places the inpatient stay in the highest-weighted DRG of its severity family. It does not count when the principal diagnosis is one of the 40 closely related codes in its exclusion list.
Can B16.0 be reported with B94.2?
Not as a rule. The Excludes1 note at block B15-B19, which applies to B16.0, lists "sequelae of viral hepatitis (B94.2)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
