2027 ICD-10-CM Diagnosis Code B10.81Human herpesvirus 6 infection

ICD-10-CM Codes›A00–B99›B10›B10

ICD-10-CM B10.81
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

B10.81 is a billable ICD-10-CM diagnosis code for human herpesvirus 6 infection. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 606 through 607. Coders also document this condition as human herpes virus 6 infection of skin. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Viral infection.

Code Identity

ICD-10-CM Code
B10.81
Billable Status
Yes — Valid for Submission
Code Describes
Human herpesvirus 6 infection
Short Description
Human herpesvirus 6 infection
Same as the full description in the CMS dataset.
Parent Code
B10.8
Other human herpesvirus infection

Code Classification

ChapterA00–B99Certain infectious and parasitic diseases
SectionB10Other human herpesviruses
CategoryB10Other human herpesviruses
This CodeB10.81Human herpesvirus 6 infection

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Human herpes virus 6 infection of skin
  • Infection by human herpesvirus 6
  • Infection caused by Roseolovirus
  • Infectious mononucleosis caused by human herpesvirus 6

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to B10.81: its own notes plus those printed at B10 and Chapter 1. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Chapter 1 (A00-B99) Certain infectious and parasitic diseases applies to 1,068 codes
  • diseases generally recognized as communicable or transmissible

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From B10 Other human herpesviruses applies to 5 codes
From Chapter 1 (A00-B99) Certain infectious and parasitic diseases applies to 1,068 codes
  • carrier or suspected carrier of infectious disease (Z22.-)
  • certain localized infections - see body system-related chapters
  • infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
  • infectious and parasitic diseases specific to the perinatal period (P35-P39)
  • influenza and other acute respiratory infections (J00-J22)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Chapter 1 (A00-B99) Certain infectious and parasitic diseases applies to 1,068 codes
  • code to identify resistance to antimicrobial drugs (Z16.-)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INF008
Viral infection
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • HHV6 Infection

    an infection that is caused by human herpesvirus-6.

Patient EducationClinical

Viral Infections

Viruses are very tiny germs. They are made of genetic material (either DNA or RNA) inside of a protein coating. There are a huge number of viruses on earth. Only a small number of them can infect humans. Those viruses can infect our cells, which may cause disease.

The full article covers:

  • What are viruses?
  • How are viruses spread?
  • How do viruses cause disease?
  • What are the treatments for viral infections?
  • Can viral infections be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert B10.81 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
058.81 Human herpesvirus 6 infc
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About B10.81Overview

What is the ICD-10 code for human herpesvirus 6 infection?

The ICD-10-CM code for human herpesvirus 6 infection is B10.81 (sometimes written as B1081). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is B10.81 (Other human herpesvirus infection) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report human herpesvirus 6 infection on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does B10.81 group to?

When human herpesvirus 6 infection is the principal diagnosis on an inpatient stay, it groups to MS-DRG 607, 606, with relative weights from 0.8772 to 1.5721 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of B10.81?

Under the General Equivalence Mappings, human herpesvirus 6 infection converts to ICD-9-CM 058.81 (human herpesvirus 6 infc). The mapping is approximate, so confirm the match fits the documentation.