2026 ICD-10-CM Diagnosis Code B10.81Human herpesvirus 6 infection

ICD-10-CM Codes›A00–B99›B10›B10

ICD-10-CM B10.81
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

B10.81 is a billable ICD-10-CM diagnosis code for human herpesvirus 6 infection. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 606 through 607. Coders also document this condition as human herpes virus 6 infection of skin. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Viral infection.

Code Identity

ICD-10-CM Code
B10.81
Billable Status
Yes — Valid for Submission
Code Describes
Human herpesvirus 6 infection
Short Description
Human herpesvirus 6 infection
Same as the full description in the CMS dataset.
Parent Code
B10.8
Other human herpesvirus infection

Code Classification

ChapterA00–B99Certain infectious and parasitic diseases
SectionB10Other human herpesviruses
CategoryB10Other human herpesviruses
This CodeB10.81Human herpesvirus 6 infection

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Human herpes virus 6 infection of skin
  • Infection by human herpesvirus 6
  • Infection caused by Roseolovirus
  • Infectious mononucleosis caused by human herpesvirus 6

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Herpes, herpesvirus, herpetic
      • human
        • 6
          • specified NEC

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INF008
Viral infection
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Viral Infections

Viruses are very tiny germs. They are made of genetic material (either DNA or RNA) inside of a protein coating. There are a huge number of viruses on earth. Only a small number of them can infect humans. Those viruses can infect our cells, which may cause disease.

The full article covers:

  • What are viruses?
  • How are viruses spread?
  • How do viruses cause disease?
  • What are the treatments for viral infections?
  • Can viral infections be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert B10.81 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
058.81 Human herpesvirus 6 infc
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About B10.81Overview

Is B10.81 (Other human herpesvirus infection) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report human herpesvirus 6 infection on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does B10.81 group to?

When human herpesvirus 6 infection is the principal diagnosis on an inpatient stay, it groups to MS-DRG 606, 607, with relative weights from 0.9064 to 1.5132 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of B10.81?

Under the General Equivalence Mappings, human herpesvirus 6 infection converts to ICD-9-CM 058.81 (human herpesvirus 6 infc). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.