2026 ICD-10-CM Diagnosis Code A49.1Streptococcal infection, unspecified site

ICD-10-CM Codes›A00–B99›A30-A49›A49

ICD-10-CM A49.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

A49.1 is a billable ICD-10-CM diagnosis code for streptococcal infection, unspecified site. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 867 through 869. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Bacterial infections.

Code Identity

ICD-10-CM Code
A49.1
Billable Status
Yes — Valid for Submission
Code Describes
Streptococcal infection, unspecified site
Short Description
Streptococcal infection, unspecified site
Same as the full description in the CMS dataset.
Parent Code
A49
Bacterial infection of unspecified site

Code Classification

ChapterA00–B99Certain infectious and parasitic diseases
SectionA30-A49Other bacterial diseases
CategoryA49Bacterial infection of unspecified site
This CodeA49.1Streptococcal infection, unspecified site

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Bacterial infection caused by Streptococcus milleri group
  • Drug resistant Streptococcus pneumoniae disease
  • Infantile streptococcal infection
  • Infection caused by alpha-hemolytic Streptococcus
  • Infection caused by beta-hemolytic Streptococcus
  • Infection caused by gamma-hemolytic Streptococcus
  • Infection caused by Streptococcus gallolyticus
  • Infection caused by Streptococcus group D
  • Infection caused by Streptococcus group G
  • Infection caused by Streptococcus iniae
  • Infection caused by Streptococcus mitis group
  • Infection caused by Streptococcus suis
  • Infection caused by Streptococcus viridans group
  • Invasive beta-hemolytic streptococcal disease
  • Invasive beta-hemolytic streptococcal disease, non-Group A, non-Group B
  • Invasive drug resistant Streptococcus pneumoniae disease
  • Invasive streptococcal disease
  • Invasive Streptococcus pneumoniae disease
  • Neonatal streptococcal infection
  • Pneumococcal infectious disease
  • Streptococcal infectious disease
  • Streptococcus agalactiae infection
  • Streptococcus anginosus or Streptococcus dysgalactiae subspecies dysgalactiae
  • Streptococcus anginosus or Streptococcus intermedius
  • Streptococcus constellatus or Streptococcus anginosus
  • Streptococcus group B infection of the infant
  • Streptococcus group B infection of the infant - age less than 30 days
  • Streptococcus lutetiensis or Streptococcus bovis
  • Streptococcus mitis or Streptococcus oralis
  • Streptococcus pyogenes infection
  • Streptococcus sanguinis or Streptococcus gordonii

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Infection, infected, infective(opportunistic)
      • pneumococcus, pneumococcal NEC
    • Infection, infected, infective(opportunistic)
      • streptococcal NEC

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INF003
Bacterial infections
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Streptococcal Infections

Strep is short for Streptococcus, a type of bacteria. There are several types. Two of them cause most of the strep infections in people: group A and group B.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert A49.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
041.00 Streptococcus unspecf
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About A49.1Overview

Is A49.1 (Bacterial infection of unspecified site) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report streptococcal infection, unspecified site on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does A49.1 group to?

When streptococcal infection, unspecified site is the principal diagnosis on an inpatient stay, it groups to MS-DRG 867, 868, 869, with relative weights from 0.7297 to 2.0932 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of A49.1?

Under the General Equivalence Mappings, streptococcal infection, unspecified site converts to ICD-9-CM 041.00 (Streptococcus unspecf). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.