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  3. A00–B99
  4. A30-A49
  5. Other sepsis (A41)

Other sepsis (A41)

The A41 ICD-10 code section covers various types of sepsis caused by different bacteria, including staphylococci, Gram-negative organisms, and others. These codes are used specifically to identify and document sepsis infections by their bacterial origin and resistance pattern.

Sepsis codes under A41 differentiate infections such as sepsis due to Staphylococcus aureus with further specificity for methicillin-susceptible (A41.01) and methicillin-resistant strains (A41.02). Other codes cover sepsis from organisms like Hemophilus influenzae (A41.3), anaerobic bacteria (A41.4), and various Gram-negative bacteria including Escherichia coli (A41.51) and Pseudomonas (A41.52). The section also includes codes for sepsis caused by less common or unspecified bacteria (A41.9). These distinctions help medical coders accurately report infections such as “septic shock due to methicillin susceptible Staphylococcus aureus” or “sepsis caused by Gram-negative bacteria,” improving clinical documentation and data tracking for targeted care and epidemiology. The ICD-10 code for other sepsis enables precise identification of bacterial sepsis types beyond more general septicemia codes.

Instructional Notations

Code First

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.

Type 1 Excludes

A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

  • bacteremia NOS R78.81
  • neonatal P36
  • puerperal sepsis O85
  • streptococcal sepsis A40

Type 2 Excludes

A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.

  • sepsis due to in actinomycotic A42.7
  • sepsis due to in anthrax A22.7
  • sepsis due to in candidal B37.7
  • sepsis due to in Erysipelothrix A26.7
  • sepsis due to in extraintestinal yersiniosis A28.2
  • sepsis due to in gonococcal A54.86
  • sepsis due to in herpesviral B00.7
  • sepsis due to in listerial A32.7
  • sepsis due to in melioidosis A24.1
  • sepsis due to in meningococcal A39.2 A39.4
  • sepsis due to in plague A20.7
  • sepsis due to in tularemia A21.7
  • toxic shock syndrome A48.3

Clinical Terms

The following clinical terms provide additional context, helping users better understand the clinical background and common associations for each diagnosis listed in this section. Including related terms alongside ICD-10-CM codes supports coders, billers, and healthcare professionals in improving accuracy, enhancing documentation, and facilitating research or patient education.

Acute Lung Injury

A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).

Burkholderia

A genus of gram-negative, aerobic, rod-shaped bacteria originally classified as members of the PSEUDOMONADACEAE.

Burkholderia Infections

Infections with bacteria of the genus BURKHOLDERIA.

Lemierre Syndrome

A superinfection of the damaged oropharyngeal mucosa by FUSOBACTERIUM NECROPHORUM leading to the secondary septic THROMBOPHLEBITIS of the internal jugular vein.

Neonatal Sepsis

Blood infection that occurs in an infant younger than 90 days old. Early-onset sepsis is seen in the first week of life and most often appears within 24 hours of birth. Late-onset occurs after 1 week and before 3 months of age.

Pregnancy Complications, Infectious

The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.

Puerperal Infection

An infection occurring in PUERPERIUM, the period of 6-8 weeks after giving birth.

Sepsis

Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Sepsis-Associated Encephalopathy

Acute neurological dysfunction during severe SEPSIS in the absence of direct brain infection characterized by systemic inflammation and BLOOD BRAIN BARRIER perturbation.

Systemic Inflammatory Response Syndrome

A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA <36 degrees C; (2) TACHYCARDIA >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.

Transfusion-Related Acute Lung Injury

A rare but serious transfusion-related reaction in which fluid builds up in the lungs unrelated to excessively high infusion rate and/or volume (TRANSFUSION-ASSOCIATED CIRCULATORY OVERLOAD). Signs of Transfusion-Related Acute Lung Injury include pulmonary secretions; hypotension; fever; DYSPNEA; TACHYPNEA; TACHYCARDIA; and CYANOSIS.