ICD-10-CM Use Additional Code Notes · Chapter 3 · FY 2027 D50-D89

Use Additional Code Notes in Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism ICD-10-CM

A Use Additional Code note means a second code should be added, after this one, to fully describe the condition. In Chapter 3 (D50-D89), notes printed in the chapter name other codes 50 times, and Use Additional Code Notes anywhere in the Tabular List name the chapter’s codes 12 times, covering 6 distinct codes, categories and ranges. Switch views to read the list either way.

✓ From the official FY 2027 ICD-10-CM Tabular ListDefinitions follow the Official Guidelines, Section I.A
50
References in Its Notes
12
References to Its Codes
6
Chapter Codes Named
D50-D89
Chapter 3
Chapter 3

Use Additional Code Notes by the code that carries the note

30 of 30 shown
  • D52.1 Drug-induced folate deficiency anemia
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • D56.0 Alpha thalassemia
    • code, if applicable, for hydrops fetalis due to alpha thalassemia (P56.99)
  • D57 Sickle-cell disorders applies to 43 codes
    • code for any associated fever (R50.81)
  • D57.09 Hb-SS disease with crisis with other specified complication
  • D57.218 Sickle-cell/Hb-C disease with crisis with other specified complication
  • D57.418 Sickle-cell thalassemia, unspecified, with crisis with other specified complication
  • D57.438 Sickle-cell thalassemia beta zero with crisis with other specified complication
  • D57.458 Sickle-cell thalassemia beta plus with crisis with other specified complication
  • D57.818 Other sickle-cell disorders with crisis with other specified complication
  • D59.0 Drug-induced autoimmune hemolytic anemia
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • D59.2 Drug-induced nonautoimmune hemolytic anemia
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • D59.31 Infection-associated hemolytic-uremic syndrome
    • E. coli infection (B96.2-)
    • Human immunodeficiency virus [HIV] disease (B20)
    • Pneumococcal meningitis (G00.1)
    • Pneumococcal pneumonia (J13)
    • Sepsis due to Streptococcus pneumoniae (A40.3)
    • Shigella dysenteriae (A03.9)
    • Streptococcus pneumoniae as the cause of diseases classified elsewhere (B95.3)
  • D59.39 Other hemolytic-uremic syndrome
    • code, if applicable, for adverse effect to identify drug (T36-T50 with fifth or sixth character 5)
  • D61.02 Shwachman-Diamond syndrome
    • code, if applicable, for genetic susceptibility to other malignant neoplasm (Z15.09)
  • D61.1 Drug-induced aplastic anemia
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • D64.2 Secondary sideroblastic anemia due to drugs and toxins
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • D68.32 Hemorrhagic disorder due to extrinsic circulating anticoagulants
    • code for adverse effect, if applicable, to identify drug (T45.515, T45.525)
  • D70 Neutropenia applies to 7 codes
  • D70.1 Agranulocytosis secondary to cancer chemotherapy
    • code for adverse effect, if applicable, to identify drug (T45.1X5)
  • D70.2 Other drug-induced agranulocytosis
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • D72.12 Drug rash with eosinophilia and systemic symptoms syndrome
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • D75.81 Myelofibrosis
    • code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)
    • code for adverse effect, if applicable, to identify drug (T45.1X5)
  • D75.82 Heparin induced thrombocytopenia (HIT) applies to 4 codes
    • code, if applicable, for adverse effect of heparin (T45.515-)
  • D75.84 Other platelet-activating anti-PF4 disorders
    • code, if applicable, for adverse effect of other viral vaccine (T50.B95-)
  • D84.821 Immunodeficiency due to drugs
    • code for adverse effect if applicable, to identify adverse effect of drug (T36-T50 with fifth or six character 5)
    • long term (current) drug therapy systemic steroids (Z79.52)
    • other long term (current) drug therapy (Z79.899)
  • D84.822 Immunodeficiency due to external causes
    • exposure to ionizing radiation (W88)
  • D89.3 Immune reconstitution syndrome
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • D89.44 Hereditary alpha tryptasemia
    • allergy status, other than to drugs and biological substances (Z91.0-)
    • personal history of anaphylaxis (Z87.892)
  • D89.81 Graft-versus-host disease applies to 4 codes
  • D89.83 Cytokine release syndrome applies to 6 codes
    • code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)

The first view lists notes printed in this chapter (a note on a category or block applies to every code beneath it). The second lists codes of this chapter named by Use Additional Code Notes anywhere in the Tabular List, including notes in other chapters.

Questions About Use Additional Code Notes

What does a Use Additional Code note mean?

A Use Additional Code note tells you to add a second code, reported after the code that carries the note, to describe the condition completely. In an etiology/manifestation pair it sits at the etiology code and points to the manifestation (Section I.A.13). The FY 2027 Tabular List has 1,491 of them; 1,174 name other codes, with 1,438 references to 389 distinct codes, categories and ranges.

Where does the additional code go?

After the code carrying the note. For etiology/manifestation pairs the Guidelines are explicit: the etiology is sequenced first, followed by the manifestation code.

Related References

ICD-10-CM Official GuidelinesICD-10-CM Code LookupICD-10-CM Codes ListCode Lists by Tag

Source: FY 2027 ICD-10-CM Tabular List (CMS and NCHS) and the ICD-10-CM Official Guidelines for Coding and Reporting FY 2027, Section I.A. ICD List is not affiliated with CMS or NCHS.