2027 ICD-10-CM Diagnosis Code Z00.6Encounter for examination for normal comparison and control in clinical research program

ICD-10-CM Codes›Z00–Z99›Z00-Z13›Z00

ICD-10-CM Z00.6
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

Z00.6 is a billable ICD-10-CM diagnosis code for encounter for examination for normal comparison and control in clinical research program. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 951. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Medical examination/evaluation.

Code Identity

ICD-10-CM Code
Z00.6
Billable Status
Yes — Valid for Submission
Code Describes
Encounter for examination for normal comparison and control in clinical research program
Short Description
Encntr for exam for nrml cmprsn and ctrl in clncl rsrch prog
Parent Code
Z00
Encounter for general examination without complaint, suspected or reported diagnosis

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ00-Z13Persons encountering health services for examinations
CategoryZ00Encounter for general examination without complaint, suspected or reported diagnosis
This CodeZ00.6Encounter for examination for normal comparison and control in clinical research program

Present on Admission (POA)Billing

Z00.6 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Persons encountering health services for examinations (Z00-Z13).

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to Z00.6: its own notes plus those printed at Z00, block Z00-Z13, and Chapter 21. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Examination of participant or control in clinical research program

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Z00 Encounter for general examination without complaint, suspected or reported diagnosis applies to 13 codes
  • encounter for examination for administrative purposes (Z02.-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Z00 Encounter for general examination without complaint, suspected or reported diagnosis applies to 13 codes
  • encounter for pre-procedural examinations (Z01.81-)
  • special screening examinations (Z11-Z13)
From Block Z00-Z13 Persons encountering health services for examinations applies to 156 codes
  • examinations related to pregnancy and reproduction (Z30-Z36, Z39.-)

Notes

General instructions on how these codes are used.

From Block Z00-Z13 Persons encountering health services for examinations applies to 156 codes
  • Nonspecific abnormal findings disclosed at the time of these examinations are classified to categories R70-R94.
From Chapter 21 (Z00-Z99) Factors influencing health status and contact with health services applies to 1,425 codes
  • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
  • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
  • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name Z00.6, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming Z00.6: they are not reported together with it, unless the two conditions are unrelated.

  • Z02.7 Encounter for issue of medical certificate
    encounter for general medical examination (Z00-Z01, Z02.0-Z02.6, Z02.8-Z02.9) names Z00-Z01, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC014
Medical examination/evaluation
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Clinical Trials

Clinical trials are research studies that test how well new medical approaches work in people. Each study answers scientific questions and tries to find better ways to prevent, screen for, diagnose, or treat a disease. Clinical trials may also compare a new treatment to a treatment that is already available.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Z00.6 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V70.7 Exam-clincal trial
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About Z00.6Overview

Is Z00.6 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report encounter for examination for normal comparison and control in clinical research program on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does Z00.6 group to?

When encounter for examination for normal comparison and control in clinical research program is the principal diagnosis on an inpatient stay, it groups to MS-DRG 951 (other Factors Influencing Health Status), which carries a relative weight of 0.5574. Higher weights mean higher Medicare reimbursement.

Is Z00.6 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for encounter for examination for normal comparison and control in clinical research program on inpatient claims. The code appears in the Persons encountering health services for examinations (Z00-Z13) range of the CMS exempt list.

Can Z00.6 be reported with a code from Z02?

Not as a rule. The Excludes1 note at Z00, which applies to Z00.6, lists "encounter for examination for administrative purposes (Z02.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of Z00.6?

Under the General Equivalence Mappings, encounter for examination for normal comparison and control in clinical research program converts to ICD-9-CM V70.7 (exam-clincal trial). The mapping is a direct match.