2026 ICD-10-CM Diagnosis Code T52.4X4SToxic effect of ketones, undetermined, sequela
T52.4X4S is a billable ICD-10-CM diagnosis code for toxic effect of ketones, undetermined, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Present on Admission (POA)Billing
T52.4X4S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Coding GuidelinesGuidance
The appropriate 7th character is to be added to each code from block Toxic effect of organic solvents (T52). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
| Substance | Accidental | Self-harm | Assault | Undetermined | Adverse Effect | Underdosing |
|---|---|---|---|---|---|---|
| Acetone (oils) | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Acetone (oils)::chlorinated | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Acetone (oils)::vapor | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Acetophenone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Butanone, 2-butanone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Cyclohexanone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Diacetone alcohol | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Hexanone, 2-hexanone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Hexone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Hydroxymethylpentanone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Ketols | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Ketone oils | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| MEK (methyl ethyl ketone) | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::acetate | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::acetone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::acrylate | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::alcohol | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::aminophenol | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::amphetamine | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::androstanolone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::atropine | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::benzene | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::benzoate | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::benzol | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::bromide (gas) | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::bromide (gas)::fumigant | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::butanol | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::carbinol | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::carbonate | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::CCNU | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::cellosolve | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::cellulose | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::chloride (gas) | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::chloroformate | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::cyclohexane | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::cyclohexanol | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::cyclohexanone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::cyclohexyl acetate | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::demeton | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::dihydromorphinone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::ergometrine | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::ergonovine | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::ethyl ketone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::glucamine antimonate | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::hydrazine | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::iodide | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::isobutyl ketone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::isothiocyanate | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::mercaptan | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::morphine NEC | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::nicotinate | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::paraben | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::parafynol | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::parathion | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::peridol | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::phenidate | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::prednisolone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::prednisolone::ENT agent | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::prednisolone::ophthalmic preparation | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::prednisolone::topical NEC | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::propylcarbinol | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::rosaniline NEC | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::salicylate | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::sulfate (fumes) | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::sulfate (fumes)::liquid | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::sulfonal | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::testosterone | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
| Methyl::thiouracil | T52.4X1 | T52.4X2 | T52.4X3 | T52.4X4 | – | – |
Convert T52.4X4S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T52.4X4SOverview
Is T52.4X4S (Toxic effect of ketones, undetermined) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report toxic effect of ketones, undetermined, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T52.4X4S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the toxic effect of ketones, undetermined itself has resolved, not the original event.
What MS-DRG does T52.4X4S group to?
When toxic effect of ketones, undetermined, sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Is T52.4X4S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for toxic effect of ketones, undetermined, sequela on inpatient claims.
What is the ICD-9 equivalent of T52.4X4S?
Under the General Equivalence Mappings, toxic effect of ketones, undetermined, sequela converts to ICD-9-CM 909.1 (late eff nonmed substanc). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
