2026 ICD-10-CM Diagnosis Code T52.1X2SToxic effect of benzene, intentional self-harm, sequela
T52.1X2S is a billable ICD-10-CM diagnosis code for toxic effect of benzene, intentional self-harm, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Mental and substance use disorders; sequela; and Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Present on Admission (POA)Billing
T52.1X2S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Coding GuidelinesGuidance
The appropriate 7th character is to be added to each code from block Toxic effect of organic solvents (T52). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
a non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (adrenocorticotropic hormone) via the release of hypothalamic arginine vasopressin (arginine vasopressin) and corticotropin-releasing hormone. (from j pharmacol exp ther 1997;280(1):416-21)Benzene
toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. it is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. it was formerly used as parasiticide.Benzene Derivatives
organic compounds derived from benzene.Benzeneacetamides
compounds based on benzeneacetamide, that are similar in structure to acetanilides.Benzenesulfonamides
a group of compounds that contain sulfonamide group s-linked to a benzene ring. many benzenesulfonamide derivatives are pharmaceuticals (e.g., bosentan; sulfapyridine; and sulfadiazine; celecoxib) as their sulfonamide moiety target various enzymes (e.g., carbonic anhydrases; acetylcholinesterase; butyrylcholinesterase; and cyclooxynenase 2).Benzenesulfonates
organic salts and esters of benzenesulfonic acid.Benzyl Alcohol
a colorless liquid with a sharp burning taste and slight odor. it is used as a local anesthetic and to reduce pain associated with lidocaine injection. also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.Benzylammonium Compounds
quaternary ammonium compounds based on benzylamines with the general formula phenyl-cn+r3.Dichlorodiphenyl Dichloroethylene
an organochlorine pesticide, it is the ethylene metabolite of ddt.Dinitrochlorobenzene
a skin irritant that may cause dermatitis of both primary and allergic types. contact sensitization with dncb has been used as a measure of cellular immunity. dncb is also used as a reagent for the detection and determination of pyridine compounds.Hexachlorocyclohexane
any of several polyhalogenated organic compounds consisting of a six-carbon ring with one chlorine and one hydrogen attached to each carbon.Ibuprofen
a non-steroidal anti-inflammatory agent with analgesic, antipyretic, and anti-inflammatory propertiesIpodate
ionic monomeric contrast media. usually the sodium or calcium salts are used for examination of the gall bladder and biliary tract. (from martindale, the extra pharmacopoeia, 30th ed, p704)Phenylacetates
derivatives of phenylacetic acid. included under this heading are a variety of acid forms, salts, esters, and amides that contain the benzeneacetic acid structure. note that this class of compounds should not be confused with derivatives of phenyl acetate, which contain the phenol ester of acetic acid.Phenylmethylsulfonyl Fluoride
an enzyme inhibitor that inactivates irc-50 arvin, subtilisin, and the fatty acid synthetase complex.Phloroglucinol
a trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.Sulfamethazine
a sulfanilamide anti-infective agent. it has a spectrum of antimicrobial action similar to other sulfonamides.Sulfathiazole
a sulfathiazole compound that is used as a short-acting anti-infective agent. it is no longer commonly used systemically due to its toxicity, but may still be applied topically in combination with other drugs for the treatment of vaginal and skin infections, and is still used in veterinary medicine.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
| Substance | Accidental | Self-harm | Assault | Undetermined | Adverse Effect | Underdosing |
|---|---|---|---|---|---|---|
| Benzene | T52.1X1 | T52.1X2 | T52.1X3 | T52.1X4 | – | – |
| Benzene::homologues (acetyl) (dimethyl) (methyl) (solvent) | T52.1X1 | T52.1X2 | T52.1X3 | T52.1X4 | – | – |
| Benzol (benzene) | T52.1X1 | T52.1X2 | T52.1X3 | T52.1X4 | – | – |
| Benzol (benzene)::vapor | T52.1X1 | T52.1X2 | T52.1X3 | T52.1X4 | – | – |
| Diphenylmethane dye | T52.1X1 | T52.1X2 | T52.1X3 | T52.1X4 | – | – |
Patient EducationClinical
Poisoning
A poison is any substance that is harmful to your body. You might swallow it, inhale it, inject it, or absorb it through your skin. Any substance can be poisonous if too much is taken. Poisons can include:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T52.1X2S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T52.1X2SOverview
Is T52.1X2S (Toxic effect of benzene, intentional self-harm) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report toxic effect of benzene, intentional self-harm, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T52.1X2S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the toxic effect of benzene, intentional self-harm itself has resolved, not the original event.
What MS-DRG does T52.1X2S group to?
When toxic effect of benzene, intentional self-harm, sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Is T52.1X2S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for toxic effect of benzene, intentional self-harm, sequela on inpatient claims.
What is the ICD-9 equivalent of T52.1X2S?
Under the General Equivalence Mappings, toxic effect of benzene, intentional self-harm, sequela converts to ICD-9-CM 909.1 (late eff nonmed substanc). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
