2026 ICD-10-CM Diagnosis Code R74.8Abnormal levels of other serum enzymes
ICD-10-CM Codes›R00–R99›R70-R79›R74
- Billable — Valid for Submission
- Not Chronic
R74.8 is a billable ICD-10-CM diagnosis code for abnormal levels of other serum enzymes. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 947 through 948. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Abnormal findings without diagnosis.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Absence of renin secretion
- Absent renal function
- Alkaline phosphatase above reference range
- Alkaline phosphatase bone isoenzyme above reference range
- Alkaline phosphatase bone isoenzyme below reference range
- Creatine kinase below reference range
- Creatine kinase level above reference range
- Deficiency of alkaline phosphatase
- Finding of gamma-glutamyl transferase level
- Finding of plasma creatine kinase level
- Finding of serum creatine kinase level
- Gamma-enolase level above reference range
- Gamma-glutamyl transferase above reference range
- Gamma-glutamyl transferase below reference range
- Gamma-glutamyl transferase level outside reference range
- High lipase level in serum
- Intestinal alkaline phosphatase above reference range
- Intestinal alkaline phosphatase below reference range
- Isolated asymptomatic elevation of creatine phosphokinase
- Liver enzymes level above reference range
- Liver enzymes level above reference range due to cystic fibrosis
- Low alkaline phosphatase due to chronic kidney disease
- Pancreatic enzyme level above reference range
- Placental alkaline phosphatase above reference range
- Placental alkaline phosphatase below reference range
- Plasma creatine kinase above reference range
- Plasma creatine kinase below reference range
- Serum 5-nucleotidase level above reference range
- Serum acid phosphatase above reference range
- Serum acid phosphatase below reference range
- Serum alkaline phosphatase above reference range
- Serum alkaline phosphatase below reference range
- Serum alkaline phosphatase level - finding
- Serum amylase above reference range
- Serum amylase outside reference range
- Serum creatine kinase above reference range
- Serum creatine kinase below reference range
- Serum lactate dehydrogenase level above reference range
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Abnormal level of acid phosphatase
- Abnormal level of alkaline phosphatase
- Abnormal level of amylase
- Abnormal level of lipase triacylglycerol lipase
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Abnormal, abnormality, abnormalities - See Also: Anomaly;
- acid phosphatase - R74.8
- alkaline phosphatase - R74.8
- amylase - R74.8
- specified NEC - R74.8
- lipase - R74.8
- triacylglycerol lipase - R74.8
- alkaline phosphatase - R74.8
- hepatic enzyme - R74.8
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Abnormal, abnormality, abnormalities
- serum level (of)
- acid phosphatase
- Abnormal, abnormality, abnormalities
- serum level (of)
- alkaline phosphatase
- Abnormal, abnormality, abnormalities
- serum level (of)
- amylase
- Abnormal, abnormality, abnormalities
- serum level (of)
- enzymes
- specified NEC
- Abnormal, abnormality, abnormalities
- serum level (of)
- lipase
- Abnormal, abnormality, abnormalities
- serum level (of)
- triacylglycerol lipase
- Elevated, elevation
- liver function
- test
- alkaline phosphatase
- Elevated, elevation
- liver function
- test
- hepatic enzyme
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Convert R74.8 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About R74.8Overview
Is R74.8 (Abnormal serum enzyme levels) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report abnormal levels of other serum enzymes on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does R74.8 group to?
When abnormal levels of other serum enzymes is the principal diagnosis on an inpatient stay, it groups to MS-DRG 947, 948, with relative weights from 0.8005 to 1.2694 depending on complications. Higher weights mean higher Medicare reimbursement.
Can R74.8 be a principal diagnosis?
Use it with care. This is a symptom code, so once a definitive diagnosis explaining the abnormal levels of other serum enzymes is established, that condition takes the principal position instead.
What is the ICD-9 equivalent of R74.8?
Under the General Equivalence Mappings, abnormal levels of other serum enzymes converts to ICD-9-CM 790.5 (abn serum enzy level NEC). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
