2026 ICD-10-CM Diagnosis Code R74Abnormal serum enzyme levels

ICD-10-CM Codes›R00–R99›R70-R79›R74

ICD-10-CM R74
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R74 is a non-billable ICD-10-CM category code for abnormal serum enzyme levels, so it cannot be submitted on claims. Use a more specific code from this category instead, such as R74.01, R74.02, R74.8, and R74.9. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established.

Code Identity

ICD-10-CM Code
R74
Billable Status
No — Non-Billable Category
Code Describes
Abnormal serum enzyme levels
Chapter
R70-R79
Abnormal findings on examination of blood, without diagnosis

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR70-R79Abnormal findings on examination of blood, without diagnosis
CategoryR74Abnormal serum enzyme levels
This CodeR74Abnormal serum enzyme levels

Specific Coding for Abnormal serum enzyme levelsOverview

Non-specific codes like R74 require more characters. Use one of these billable codes instead:

  • R74.0 for Nonspecific elevation of levels of transaminase and lactic acid dehydrogenase [LDH]

  • Use R74.01 for Elevation of levels of liver transaminase levels

  • Use R74.02 for Elevation of levels of lactic acid dehydrogenase [LDH]

  • Use R74.8 for Abnormal levels of other serum enzymes

  • Use R74.9 for Abnormal serum enzyme level, unspecified

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R74Overview

Is R74 (Abnormal serum enzyme levels) a billable code?

No. This is a category header that groups the codes for abnormal serum enzyme levels, and headers cannot be submitted on claims. Claims for abnormal serum enzyme levels need a more specific code from this category, such as R74.01, R74.02, and R74.8.

Can R74 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the abnormal serum enzyme levels is established, that condition takes the principal position instead.