Abnormal serum enzyme levels (R74) ICD-10-CM
The R74 code range covers abnormal serum enzyme levels with 6 ICD-10-CM diagnosis codes. 4 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Codes in the R74 Range 6 codes · 4 billable
- R74 Abnormal serum enzyme levelsNon-billable
- R74.0 Nonspecific elevation of levels of transaminase and lactic acid dehydrogenase [LDH]Non-billable
- R74.01 Elevation of levels of liver transaminase levels
- R74.02 Elevation of levels of lactic acid dehydrogenase [LDH]
- R74.8 Abnormal levels of other serum enzymes
- R74.9 Abnormal serum enzyme level, unspecified
About the R74 Code Range
The ICD-10 code R74 covers various abnormal serum enzyme levels detected in blood tests, used to classify findings without a specific diagnosis. These codes help identify elevated or abnormal enzyme activity related to liver function, muscle injury, and other organ systems.
R74.0 is for nonspecific elevation of transaminase enzymes and lactic acid dehydrogenase (LDH), common markers for tissue damage. More specific codes like R74.01 indicate elevated liver transaminase levels, often referenced as aspartate transaminase or alanine aminotransferase outside their normal ranges. R74.02 is assigned when only lactic acid dehydrogenase levels are elevated. The code R74.8 applies to abnormal levels of other serum enzymes, covering a broad set of enzymes such as creatine kinase, alkaline phosphatase, amylase, and gamma-glutamyl transferase. Finally, R74.9 captures unspecified abnormal serum enzyme findings, referred to generally as a high enzyme level in serum. These codes are essential for accurately recording abnormal lab results that require further clinical correlation.
Questions About This Page
How many billable codes are in the R74 range?
Of the 6 codes in this range, 4 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the R74 range classify?
The range classifies abnormal serum enzyme levels. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
