2026 ICD-10-CM Diagnosis Code N46.121Oligospermia due to drug therapy

ICD-10-CM Codes›N00–N99›N40-N53›N46

ICD-10-CM N46.121
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

N46.121 is a billable ICD-10-CM diagnosis code for oligospermia due to drug therapy. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 729 through 730. The code is restricted by the Medicare Code Editor to adult patients (age 15 through 124). Coders also document this condition as hypospermatogenesis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Male infertility.

Code Identity

ICD-10-CM Code
N46.121
Billable Status
Yes — Valid for Submission
Code Describes
Oligospermia due to drug therapy
Short Description
Oligospermia due to drug therapy
Same as the full description in the CMS dataset.
Parent Code
N46.12
Oligospermia due to extratesticular causes

Code Classification

ChapterN00–N99Diseases of the genitourinary system
SectionN40-N53Diseases of male genital organs
CategoryN46Male infertility
This CodeN46.121Oligospermia due to drug therapy

Code EditsBilling

Medicare Code Editor checks that affect claim validity for N46.121.

Adult diagnoses
The Medicare Code Editor detects inconsistencies in adult cases by checking a patient's age and any diagnosis on the patient's record. The adult code edits apply to patients age range is 15–124 years inclusive (e.g., senile delirium, mature cataract).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Hypospermatogenesis
  • Oligozoospermia
  • Oligozoospermia due to drug therapy

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Infertility
      • male
        • oligospermia
          • extratesticular cause
            • drug therapy
    • Oligospermia
      • due to
        • drug therapy

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient No · outpatient No
CCSR GEN015
Male infertility
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

The full article covers:

  • What is a drug interaction?
  • What are side effects?
  • What are drug allergies?
  • How can I stay safe when taking medicines?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert N46.121 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
606.1 Oligospermia
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About N46.121Overview

Is N46.121 (Oligospermia due to extratesticular causes) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report oligospermia due to drug therapy on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does N46.121 group to?

When oligospermia due to drug therapy is the principal diagnosis on an inpatient stay, it groups to MS-DRG 729, 730, with relative weights from 0.6720 to 1.0587 depending on complications. Higher weights mean higher Medicare reimbursement.

Who can N46.121 be reported for?

The Medicare Code Editor checks oligospermia due to drug therapy against patient demographics: this code is intended for adult patients (age 15 through 124). Claims outside these limits are flagged as inconsistent.

What is the ICD-9 equivalent of N46.121?

Under the General Equivalence Mappings, oligospermia due to drug therapy converts to ICD-9-CM 606.1 (oligospermia). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.