2026 ICD-10-CM Diagnosis Code M32.10Systemic lupus erythematosus, organ or system involvement unspecified

ICD-10-CM Codes›M00–M99›M30-M36›SLE

ICD-10-CM M32.10
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

M32.10 is a billable ICD-10-CM diagnosis code for systemic lupus erythematosus, organ or system involvement unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 545 through 547. Coders also document this condition as connective tissue disease overlap syndrome. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Systemic lupus erythematosus and connective tissue disorders.

Code Identity

ICD-10-CM Code
M32.10
Billable Status
Yes — Valid for Submission
Code Describes
Systemic lupus erythematosus, organ or system involvement unspecified
Short Description
Systemic lupus erythematosus, organ or system involv unsp
Parent Code
M32.1
Systemic lupus erythematosus with organ or system involvement

Code Classification

ChapterM00–M99Diseases of the musculoskeletal system and connective tissue
SectionM30-M36Systemic connective tissue disorders
CategorySLESystemic lupus erythematosus (M32)
This CodeM32.10Systemic lupus erythematosus, organ or system involvement unspecified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Connective tissue disease overlap syndrome
  • Fulminating systemic lupus erythematosus
  • Lupus erythematosus overlap syndrome
  • Mixed collagen vascular disease
  • Overlap syndrome
  • Systemic lupus erythematosus with multisystem involvement
  • Systemic lupus erythematosus with organ/system involvement
  • Systemic lupus erythematosus-related syndrome

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Lupus
      • erythematosus (discoid) (local)
        • systemic
          • with organ or system involvement

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MUS024
Systemic lupus erythematosus and connective tissue disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Exosome Component 10|Autoantigen PM-SCL|Autoantigen PM/Scl|EC 3.1.13.-|EXOSC10|P100 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen|PM/Scl-100|Polymyositis/Scleroderma Autoantigen 100 kDa|Polymyositis/Scleroderma Autoantigen 2

    exosome component 10 (885 aa, ~101 kda) is encoded by the human exosc10 gene. this protein plays a role in the maturation and degradation of rna.

  • Other Overlap Syndromes|Other overlap syndromes

    evidence of other overlap syndromes not specified elsewhere.

  • Overlap Syndrome

    an autoimmune, connective tissue disorder in which the patient exhibits features from two or more diseases. these typically include systemic sclerosis, dermatomyositis, polymyositis, rheumatoid arthritis, systemic lupus erythematosus, and sjogren syndrome; in pediatrics the respective pediatric entities are encountered.

  • Scleroderma Polymyositis Overlap Syndrome|Scleroderma Polymyositis

    a rare autoimmune disorder in which patients present with overlapping symptoms of systemic scleroderma and polymyositis or dermatomyositis.

  • Exosome Complex Component RRP45|AMPA RECEPTORS|Autoantigen PM/Scl 1|EXOSC9|Exosome Component 9|GLuRs|P75 Polymyositis-Scleroderma Autoantigen|P75 Polymyositis-Scleroderma Overlap Syndrome Associated Autoantigen|P75 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen|PM/Scl-75|Polymyositis/Scleroderma Autoantigen 1|Polymyositis/Scleroderma Autoantigen 75 kDa

    exosome complex component rrp45 (439 aa, ~49 kda) is encoded by the human exosc9 gene. this protein is involved in the regulation of the exoribonuclease activity of the exosome.

  • Exosome Component 10|Autoantigen PM-SCL|Autoantigen PM/Scl|EC 3.1.13.-|EXOSC10|EXOSC10|P100 POLYMYOSITIS-SCLERODERMA AUTOANTIGEN|P100 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen|PM/Scl 2|PM/Scl-100|PM/Scl-100|Polymyositis/Scleroderma Autoantigen 100 kDa|Polymyositis/Scleroderma Autoantigen 2|Polymyositis/Scleroderma Autoantigen 2

    exosome component 10 (885 aa, ~101 kda) is encoded by the human exosc10 gene. this protein plays a role in the maturation and degradation of rna.

Patient EducationClinical

Lupus

Lupus is a chronic (long-lasting) type of autoimmune disease.Autoimmune diseases happen when your immune system attacks healthy cells and tissues by mistake. This attack causes inflammation. It can also damage many parts of the body, including the joints, skin, kidneys, heart, lungs, and brain.

The full article covers:

  • What is lupus?
  • What causes lupus?
  • Who is more likely to get lupus?
  • What are the symptoms of lupus?
  • What other problems can lupus cause?
  • How is lupus diagnosed?
  • What are the treatments for lupus?
  • How can I cope with lupus?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert M32.10 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
710.0 Syst lupus erythematosus
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About M32.10Overview

Is M32.10 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report systemic lupus erythematosus, organ or system involvement unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does M32.10 group to?

When systemic lupus erythematosus, organ or system involvement unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 545, 546, 547, with relative weights from 0.8362 to 2.4817 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of M32.10?

Under the General Equivalence Mappings, systemic lupus erythematosus, organ or system involvement unspecified converts to ICD-9-CM 710.0 (syst lupus erythematosus). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.