2026 ICD-10-CM Diagnosis Code D72.823Leukemoid reaction
ICD-10-CM Codes›D50–D89›D70-D77›D72
- Billable — Valid for Submission
- Not Chronic
D72.823 is a billable ICD-10-CM diagnosis code for leukemoid reaction. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diseases of white blood cells.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Basophilic leukemoid reaction
- Blood monocyte number above reference range
- Complete trisomy 21 syndrome
- Down syndrome co-occurrent with leukemoid reaction associated transient neonatal pustulosis
- Leukemoid reaction
- Leukemoid reaction of the newborn
- Lymphocytic leukemoid reaction
- Monocyte count - finding
- Monocyte count outside reference range
- Monocytic leukemoid reaction
- Monocytoid disorder
- Monocytosis
- Neutrophilia disorder
- Neutrophilic leukemoid reaction
- Non-malignant lymphocyte AND/OR plasma cell disorder
- Transient neonatal pustulosis
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Basophilic leukemoid reaction
- Leukemoid reaction NOS
- Lymphocytic leukemoid reaction
- Monocytic leukemoid reaction
- Myelocytic leukemoid reaction
- Neutrophilic leukemoid reaction
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Leukemoid reaction - See Also: Reaction, leukemoid; - D72.823
- Reaction - See Also: Disorder;
- leukemoid - D72.823
- basophilic - D72.823
- lymphocytic - D72.823
- monocytic - D72.823
- myelocytic - D72.823
- neutrophilic - D72.823
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Leukemoid reaction
- Reaction
- leukemoid
- Reaction
- leukemoid
- basophilic
- Reaction
- leukemoid
- lymphocytic
- Reaction
- leukemoid
- monocytic
- Reaction
- leukemoid
- myelocytic
- Reaction
- leukemoid
- neutrophilic
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Leukemoid Reaction
a peripheral blood picture resembling that of leukemia or indistinguishable from it on the basis of morphologic appearance alone. (dorland, 27th ed)Leukemoid Reaction
a hematology test result that indicates the presence of an increased white blood cell count and increased neutrophil precursors resembling leukemia, in a peripheral blood smear.Transient Leukemoid Reaction of the Newborn|Leukemoid Reaction of the Newborn|Transient Leukemoid Reaction of Newborn
increased white blood cell count and increased neutrophil precursors resembling leukemia in a neonate or fetus. often, this is a response to medications received, infection or down syndrome.Clonal Cytopenia with Monocytosis of Undetermined Significance|CCMUS
a myelodysplastic/myeloproliferative neoplasm that fulfills the diagnostic criteria of clonal monocytosis of undetermined significance and is associated with cytopenia.Clonal Monocytosis of Undetermined Significance|CMUS
a myelodysplastic/myeloproliferative neoplasm characterized by the presence of persistent monocytosis, presence of at least one myeloid neoplasm-associated mutation, absence of significant dysplasia or increased blasts in the bone marrow, absence of morphologic findings suggestive of chronic myelomonocytic leukemia in the bone marrow, and absence of history of a reactive condition that would explain the persistent monocytosis.Monocytosis
abnormally high level of monocytes in the blood.
Patient EducationClinical
Blood Disorders
Your blood is living tissue made up of liquid and solids. The liquid part, called plasma, is made of water, salts and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells and platelets.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D72.823 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D72.823Overview
Is D72.823 (Elevated white blood cell count) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report leukemoid reaction on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D72.823 group to?
When leukemoid reaction is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D72.823?
Under the General Equivalence Mappings, leukemoid reaction converts to ICD-9-CM 288.62 (leukemoid reaction). The mapping is a direct match.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
