2026 ICD-10-CM Diagnosis Code D72.820Lymphocytosis (symptomatic)

ICD-10-CM Codes›D50–D89›D70-D77›D72

ICD-10-CM D72.820
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D72.820 is a billable ICD-10-CM diagnosis code for lymphocytosis (symptomatic). It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diseases of white blood cells.

Code Identity

ICD-10-CM Code
D72.820
Billable Status
Yes — Valid for Submission
Code Describes
Lymphocytosis (symptomatic)
Short Description
Lymphocytosis (symptomatic)
Same as the full description in the CMS dataset.
Parent Code
D72.82
Elevated white blood cell count

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD70-D77Other disorders of blood and blood-forming organs
CategoryD72Other disorders of white blood cells
This CodeD72.820Lymphocytosis (symptomatic)

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired lymphocytosis
  • Blood lymphocyte number above reference range
  • Diffuse infiltrative lymphocytosis syndrome
  • Lymphocytosis
  • Lymphocytosis - absolute
  • Monoclonal B-cell lymphocytosis
  • Monoclonal B-cell lymphocytosis chronic lymphocytic leukemia-type
  • Non-chronic lymphocytic leukemia monoclonal B-cell lymphocytosis
  • Non-malignant lymphocyte AND/OR plasma cell disorder
  • Persistent lymphocytosis
  • Persistent polyclonal B-cell lymphocytosis
  • Relative lymphocytosis
  • T lymphocyte disorder
  • T-cell lymphocytosis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Elevated lymphocytes

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Elevated, elevation
      • lymphocytes
    • Lymphocytosis(symptomatic)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD007
Diseases of white blood cells
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Leukemia, Large Granular Lymphocytic

    a spectrum of disorders characterized by clonal expansions of the peripheral blood lymphocyte populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. subtypes develop from either cd3-negative natural killer cells or cd3-positive t-cells. the clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.

  • Lymphocytosis

    excess of normal lymphocytes in the blood or in any effusion.

  • Lymphohistiocytosis, Hemophagocytic

    a group of related disorders characterized by lymphocytosis; histiocytosis; and hemophagocytosis. the two major forms are familial and reactive.

  • Pertussis Toxin

    one of the virulence factors produced by bordetella pertussis. it is a multimeric protein composed of five subunits s1 - s5. s1 contains mono adpribose transferase activity.

  • Virulence Factors, Bordetella

    a set of bacterial adhesins and toxins, biological produced by bordetella organisms that determine the pathogenesis of bordetella infections, such as whooping cough. they include filamentous hemagglutinin; fimbriae proteins; pertactin; pertussis toxin; adenylate cyclase toxin; dermonecrotic toxin; tracheal cytotoxin; bordetella lipopolysaccharides; and tracheal colonization factor.

  • Bordetella pertussis

    a species of gram-negative, aerobic bacteria that is the causative agent of whooping cough. its cells are minute coccobacilli that are surrounded by a slime sheath.

Patient EducationClinical

Blood Disorders

Your blood is living tissue made up of liquid and solids. The liquid part, called plasma, is made of water, salts and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells and platelets.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D72.820 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
288.61 Lymphocytosis-symptomatc
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D72.820Overview

Is D72.820 (Elevated white blood cell count) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report lymphocytosis (symptomatic) on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D72.820 group to?

When lymphocytosis (symptomatic) is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D72.820?

Under the General Equivalence Mappings, lymphocytosis (symptomatic) converts to ICD-9-CM 288.61 (lymphocytosis-symptomatc). The mapping is a direct match.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.