2026 ICD-10-CM Diagnosis Code D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvement
ICD-10-CM Codes›D50–D89›D55-D59›D57
- Billable — Valid for Submission
- Chronic Condition
D57.453 is a billable ICD-10-CM diagnosis code for sickle-cell thalassemia beta plus with cerebral vascular involvement. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Sickle cell trait/anemia.
Code Identity
Code Classification
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- HbS-beta plus with cerebral vascular involvement
- Sickle-cell beta plus with cerebral vascular involvement
Code Also
- , if applicable cerebral infarction I63
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
A "code also" note instructs that two codes may be required to fully describe a condition, but this note does not provide sequencing direction.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Disease, diseased - See Also: Syndrome;
- sickle-cell - D57.1
- thalassemia - D57.40
- with
- cerebral vascular involvement - D57.453
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Disease, diseased
- hemoglobin or Hb
- S or SS
- beta plus
- with
- cerebral vascular involvement
- Disease, diseased
- sickle-cell
- thalassemia
- beta plus
- with
- cerebral vascular involvement
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Sickle Cell Disease
Sickle cell disease (SCD) is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. This changes the shape of the red blood cells.
The full article covers:
- What is sickle cell disease (SCD)?
- What causes sickle cell disease (SCD)?
- Who is more likely to have sickle cell disease (SCD)?
- What are the symptoms of sickle cell disease (SCD)?
- How is sickle cell disease (SCD) diagnosed?
- What are the treatments for sickle cell disease (SCD)?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Code History & ChangesHistory
Replacement D57.453 replaces the following previously assigned code(s):
- D57.419 - Sickle-cell thalassemia with crisis, unspecified
- D57.419 - Sickle-cell thalassemia, unspecified, with crisis
Questions About D57.453Overview
Is D57.453 (Sickle-cell thalassemia beta plus with crisis) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report sickle-cell thalassemia beta plus with cerebral vascular involvement on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D57.453 group to?
When sickle-cell thalassemia beta plus with cerebral vascular involvement is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
