2026 ICD-10-CM Diagnosis Code C96.0Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis

ICD-10-CM Codes›C00–D49›C81-C96›C96

ICD-10-CM C96.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

C96.0 is a billable ICD-10-CM diagnosis code for multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 826 through 830, 843 through 845. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Non-Hodgkin lymphoma.

Code Identity

ICD-10-CM Code
C96.0
Billable Status
Yes — Valid for Submission
Code Describes
Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis
Short Description
Multifocal and multisystemic Langerhans-cell histiocytosis
Parent Code
C96
Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue

Code Classification

ChapterC00–D49Neoplasms
SectionC81-C96Malignant neoplasms of lymphoid, hematopoietic and related tissue
CategoryC96Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue
This CodeC96.0Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Disseminated Langerhans cell histiocytosis of abdominal lymph nodes
  • Disseminated Langerhans cell histiocytosis of bone
  • Disseminated Langerhans cell histiocytosis of cervical lymph nodes
  • Disseminated Langerhans cell histiocytosis of lymph nodes of head
  • Disseminated Langerhans cell histiocytosis of lymph nodes of lower limb
  • Disseminated Langerhans cell histiocytosis of lymph nodes of multiple sites
  • Disseminated Langerhans cell histiocytosis of lymph nodes of thorax
  • Disseminated Langerhans cell histiocytosis of lymph nodes of upper limb
  • Disseminated Langerhans cell histiocytosis of pelvic lymph nodes
  • Disseminated Langerhans cell histiocytosis of spleen
  • Langerhans cell histiocytosis, disseminated

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Histiocytosis X, multisystemic
  • Letterer-Siwe disease

Type 1 Excludes

  • adult pulmonary Langerhans cell histiocytosis J84.82
  • multifocal and unisystemic Langerhans-cell histiocytosis C96.5
  • unifocal Langerhans-cell histiocytosis C96.6

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Histiocytosis
      • acute differentiated progressive
    • Histiocytosis
      • Langerhans' cell NEC
        • multifocal X
          • multisystemic (disseminated)
    • Histiocytosis
      • X NEC
        • acute (progressive)
    • Histiocytosis
      • X NEC
        • multisystemic
    • Letterer-Siwe's disease
    • Reticuloendotheliosis
      • acute infantile
    • Reticuloendotheliosis
      • nonlipid
    • Reticulosis(skin)
      • acute of infancy

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO058
Non-Hodgkin lymphoma
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Langerhans cell histiocytosis

Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. Langerhans cells, which help regulate the immune system, are normally found throughout the body, especially in the skin, lymph nodes, spleen, lungs, liver, and bone marrow.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert C96.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
202.50 Ltr-siwe unsp xtrndl org
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About C96.0Overview

Is C96.0 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does C96.0 group to?

When multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis is the principal diagnosis on an inpatient stay, it groups to MS-DRG 826, 827, 828, 829, 830, 843, 844, 845, with relative weights from 0.8516 to 4.6778 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of C96.0?

Under the General Equivalence Mappings, multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis converts to ICD-9-CM 202.50 (ltr-siwe unsp xtrndl org). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.