2026 ICD-10-CM Diagnosis Code C69.21Malignant neoplasm of right retina

AHRQ’s CCSR groups this code into broader clinical categories.

• E2F1 Transcription Factor

  an e2f transcription factor that interacts directly with retinoblastoma protein and cyclin a and activates genetic transcription required for cell cycle entry and dna synthesis. e2f1 is involved in dna repair and apoptosis.

• Genes, Retinoblastoma

  tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kda to 115 kda. one copy of the wild-type rb gene is necessary for normal retinal development. loss or inactivation of both alleles at this locus results in retinoblastoma.

• Retinoblastoma

  a malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. the tumor tends to occur in early childhood or infancy and may be present at birth. the majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. an abnormal pupil reflex (leukokoria); nystagmus, pathologic; strabismus; and visual loss represent common clinical characteristics of this condition. (from devita et al., cancer: principles and practice of oncology, 5th ed, p2104)

• Retinoblastoma Binding Proteins

  a family of endogenous regulatory proteins that associate with retinoblastoma protein via a specific high-affinity binding domain. members of this family of proteins are often found associated with histone-modifying enzymes and protein complexes that regulate gene expression.

• Retinoblastoma Protein

  product of the retinoblastoma tumor suppressor gene. it is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. rb protein is absent in retinoblastoma cell lines. it also has been shown to form complexes with the adenovirus e1a protein, the sv40 t antigen, and the human papilloma virus e7 protein.

• Retinoblastoma-Binding Protein 1

  a ubiquitously expressed regulatory protein that contains a retinoblastoma protein binding domain and an at-rich interactive domain. the protein may play a role in recruiting histone deacetylases to the site of retinoblastoma protein-containing transcriptional repressor complexes.

• Retinoblastoma-Binding Protein 2

  a retinoblastoma binding protein that is also a member of the jumonji-domain histone demethylases. it has demethylation activity towards specific lysine residues found on histone h3.

• Retinoblastoma-Binding Protein 4

  a retinoblastoma-binding protein that is involved in chromatin remodeling, histone deacetylation, and repression of genetic transcription. although initially discovered as a retinoblastoma binding protein it has an affinity for core histones and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2.

• Retinoblastoma-Binding Protein 7

  a retinoblastoma-binding protein that has an affinity for core histones. it is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the mi2 and sin3 histone deacetylase complexes and the polycomb repressive complex 2.

• Retinoblastoma-Like Protein p107

  a negative regulator of the cell cycle that undergoes phosphorylation by cyclin-dependent kinases. it contains a conserved pocket region that binds e2f4 transcription factor and interacts with viral oncoproteins such as polyomavirus tumor antigens; adenovirus e1a proteins; and papillomavirus e7 proteins.

• Retinoblastoma-Like Protein p130

  a negative regulator of the cell cycle that undergoes phosphorylation by cyclin-dependent kinases. rbl2 contains a conserved pocket region that binds e2f4 transcription factor and e2f5 transcription factor. rbl2 also interacts with viral oncoproteins such as polyomavirus tumor antigens; adenovirus e1a proteins; and papillomavirus e7 proteins.

• Histones

  small chromosomal proteins (approx 12-20 kd) possessing an open, unfolded structure and attached to the dna in cell nuclei by ionic linkages. classification into the various types (designated histone i, histone ii, etc.) is based on the relative amounts of arginine and lysine in each.

Anatomical sites in the Table of Neoplasms that reference this code family.

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Eye Cancer

Cancer of the eye is uncommon. It can affect the outer parts of the eye, such as the eyelid, which are made up of muscles, skin and nerves. If the cancer starts inside the eyeball it's called intraocular cancer. The most common intraocular cancers in adults are melanoma and lymphoma.

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