ICD-10 Diagnosis Code D64.4

Congenital dyserythropoietic anemia

Diagnosis Code D64.4

ICD-10: D64.4
Short Description: Congenital dyserythropoietic anemia
Long Description: Congenital dyserythropoietic anemia
This is the 2017 version of the ICD-10-CM diagnosis code D64.4

Code Classification
  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    • Aplastic and other anemias and other bone marrow failure syndromes (D60-D64)
      • Other anemias (D64)

Information for Medical Professionals

Diagnostic Related Groups
The diagnosis code D64.4 is grouped in the following Diagnostic Related Group(s) (MS-DRG v33.0)


Convert to ICD-9 Additional informationCallout TooltipGeneral Equivalence Map
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Chronic multifocal osteomyelitis
  • Chronic osteomyelitis of multiple sites
  • Chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anemia and neutrophilic dermatosis
  • Congenital dyserythropoietic anemia
  • Congenital dyserythropoietic anemia, type I
  • Congenital dyserythropoietic anemia, type II
  • Congenital dyserythropoietic anemia, type III
  • Osteomyelitis of multiple sites

Index of Diseases and Injuries
References found for the code D64.4 in the Index of Diseases and Injuries:

Information for Patients


Also called: Iron poor blood

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction.

Conditions that may lead to anemia include

  • Heavy periods
  • Pregnancy
  • Ulcers
  • Colon polyps or colon cancer
  • Inherited disorders
  • A diet that does not have enough iron, folic acid or vitamin B12
  • Blood disorders such as sickle cell anemia and thalassemia, or cancer
  • Aplastic anemia, a condition that can be inherited or acquired
  • G6PD deficiency, a metabolic disorder

Anemia can make you feel tired, cold, dizzy, and irritable. You may be short of breath or have a headache.

Your doctor will diagnose anemia with a physical exam and blood tests. Treatment depends on the kind of anemia you have.

NIH: National Heart, Lung, and Blood Institute

  • Anemia
  • Anemia - B12 deficiency
  • Anemia caused by low iron -- infants and toddlers
  • Anemia of chronic disease
  • Anemia of Inflammation and Chronic Disease - NIH
  • Ferritin blood test
  • Hemolytic anemia
  • Iron deficiency anemia
  • Managing Chemotherapy Side Effects: Anemia - NIH - Easy-to-Read (National Cancer Institute)
  • Pernicious anemia
  • Vitamin B12 level

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Congenital dyserythropoietic anemia Congenital dyserythropoietic anemia (CDA) is an inherited blood disorder that affects the development of red blood cells. This disorder is one of many types of anemia, which is a condition characterized by a shortage of red blood cells. This shortage prevents the blood from carrying an adequate supply of oxygen to the body's tissues. The resulting symptoms can include tiredness (fatigue), weakness, pale skin, and other complications.Researchers have identified three major types of CDA: type I, type II, and type III. The types have different genetic causes and different but overlapping patterns of signs and symptoms.CDA type I is characterized by moderate to severe anemia. It is usually diagnosed in childhood or adolescence, although in some cases, the condition can be detected before birth. Many affected individuals have yellowing of the skin and eyes (jaundice) and an enlarged liver and spleen (hepatosplenomegaly). This condition also causes the body to absorb too much iron, which builds up and can damage tissues and organs. In particular, iron overload can lead to an abnormal heart rhythm (arrhythmia), congestive heart failure, diabetes, and chronic liver disease (cirrhosis). Rarely, people with CDA type I are born with skeletal abnormalities, most often involving the fingers and/or toes.The anemia associated with CDA type II can range from mild to severe, and most affected individuals have jaundice, hepatosplenomegaly, and the formation of hard deposits in the gallbladder called gallstones. This form of the disorder is usually diagnosed in adolescence or early adulthood. An abnormal buildup of iron typically occurs after age 20, leading to complications including heart disease, diabetes, and cirrhosis.The signs and symptoms of CDA type III tend to be milder than those of the other types. Most affected individuals do not have hepatosplenomegaly, and iron does not build up in tissues and organs. In adulthood, abnormalities of a specialized tissue at the back of the eye (the retina) can cause vision impairment. Some people with CDA type III also have a blood disorder known as monoclonal gammopathy, which can lead to a cancer of white blood cells (multiple myeloma).Several other variants of CDA have been described, although they appear to be rare and not much is known about them. Once researchers discover the genetic causes of these variants, some of them may be grouped with the three major types of CDA.
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