2025 ICD-10-CM Diagnosis Code T45.1X5A
Adverse effect of antineoplastic and immunosuppressive drugs, initial encounter
- ICD-10-CM Code:
- T45.1X5A
- ICD-10 Code for:
- Adverse effect of antineoplastic and immunosup drugs, init
- Is Billable?
- Yes - Valid for Submission
- Chronic Condition Indicator: [1]
- Not chronic
- Code Navigator:
T45.1X5A is a billable diagnosis code used to specify a medical diagnosis of adverse effect of antineoplastic and immunosuppressive drugs, initial encounter. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2024 through September 30, 2025.
This code describes a circumstance which influences the patient's health status but not a current illness or injury. The code is unacceptable as a principal diagnosis.
T45.1X5A is an initial encounter code, includes a 7th character and should be used while the patient is receiving active treatment for a condition like adverse effect of antineoplastic and immunosuppressive drugs. According to ICD-10-CM Guidelines an "initial encounter" doesn't necessarily means "initial visit". The 7th character should be used when the patient is undergoing active treatment regardless if new or different providers saw the patient over the course of a treatment. The appropriate 7th character codes should also be used even if the patient delayed seeking treatment for a condition.
- Code Information
- Approximate Synonyms
- Clinical Classification
- Clinical Information
- Coding Guidelines
- Replaced Code
- Tabular List of Diseases and Injuries
- Code Edits
- Diagnostic Related Groups Mapping
- Convert to ICD-9 Code
- Table of Drugs and Chemicals
- Patient Education
- Other Codes Used Similar Conditions
- Code History
Approximate Synonyms
The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.
- Accelerated rheumatoid nodulosis
- Accelerated rheumatoid nodulosis caused by methotrexate
- Aclarubicin adverse reaction
- Acquired pancytopenia
- Acral erythema due to cytotoxic therapy
- Acute promyelocytic leukemia, FAB M3
- Adverse reaction to antineoplastic antibiotics
- Adverse reaction to dimethyl sulfoxide and/or idoxuridine
- Adverse reaction to rituximab administered by infusion
- Adverse reaction to sarilumab
- Adverse reaction to trastuzumab administered by infusion
- Adverse reaction to triazene
- Agranulocytosis
- Agranulocytosis due to and following administration of antineoplastic agent
- Aldesleukin adverse reaction
- Alkylating drug adverse reaction
- Amifostine adverse reaction
- Amsacrine adverse reaction
- Anemia caused by antineoplastic agent
- Antimetabolite adverse reaction
- Antineoplastic adverse reaction
- Aplastic anemia caused by antineoplastic agent
- Aplastic anemia due to drugs
- Azathioprine adverse reaction
- Azoospermia caused by chemotherapy
- Bleomycin adverse reaction
- Busulfan adverse reaction
- Carboplatin adverse reaction
- Cardiomyopathy caused by drug
- Carmustine adverse reaction
- Cellular atypia caused by antineoplastic agent
- Chlorambucil adverse reaction
- Chlormethine adverse reaction
- Chronic cyclosporin A nephrotoxicity
- Chronic drug-induced renal disease
- Chronic drug-induced renal disease
- Chronic drug-induced renal disease
- Chronic painful polyneuropathy
- Chronic painful polyneuropathy following chemotherapy
- Chronic peripheral neuropathic pain
- Cirrhosis of liver caused by methotrexate
- Cisplatin adverse reaction
- Cis-platinum nephropathy
- Complication of chemotherapy
- Crisantaspase adverse reaction
- Cyclophosphamide adverse reaction
- Cyclosporin adverse reaction
- Cytarabine adverse reaction
- Cytotoxic antibiotic adverse reaction
- Dacarbazine adverse reaction
- Dactinomycin adverse reaction
- Dermatosis caused by immunosuppressant
- Dermatosis due to cytotoxic therapy
- Differentiation syndrome due to and following chemotherapy co-occurrent with acute promyelocytic leukemia
- Dilated cardiomyopathy caused by anthracycline
- Dilated cardiomyopathy caused by drug
- Dimethyl sulfoxide adverse reaction
- Disorder of skin caused by epidermal growth factor receptor inhibitor
- Doxorubicin adverse reaction
- Drug-induced cirrhosis of liver
- Drug-induced immunodeficiency
- Drug-induced immunodeficiency
- Drug-induced tubulointerstitial nephritis
- Epirubicin adverse reaction
- Esophagitis due to chemotherapy
- Estramustine adverse reaction
- Ethoglucid adverse reaction
- Etoposide adverse reaction
- Fatigue due to chemotherapy
- Fludarabine adverse reaction
- Fluorouracil adverse reaction
- Gonad regulating hormone adverse reaction
- Gonad regulating hormone adverse reaction
- Gonad regulating hormone adverse reaction
- Goserelin adverse reaction
- Growing teratoma syndrome
- Heart failure following administration of antineoplastic agent
- Hematologic complication of procedure
- Hematologic complication of procedure
- Hydroxycarbamide adverse reaction
- Iatrogenic immunodeficiency-associated lymphoproliferative disorder
- Idarubicin adverse reaction
- Ifosfamide adverse reaction
- Immunodeficiency caused by long term therapeutic use of drug
- Immunodeficiency caused by long term therapeutic use of immunosuppressant
- Immunodeficiency secondary to chemotherapy
- Immunosuppressant adverse reaction
- Inflammation of mucous membrane due to and following chemotherapy
- Leuprorelin adverse reaction
- Lomustine adverse reaction
- Lymphoproliferative disorder caused by methotrexate
- Malignant neoplasm after immunosuppressive therapy
- Melphalan adverse reaction
- Mercaptopurine adverse reaction
- Methotrexate adverse reaction
- Methotrexate poisoning
- Methotrexate skin ulceration
- Methyl CCNU nephropathy
- Mitobronitol adverse reaction
- Mitomycin adverse reaction
- Mitoxantrone adverse reaction
- Myelopathy post intrathecal injection of chemotherapeutic agent
- Myelosuppression
- Myelosuppression due to chemotherapy
- Nephritis caused by drug
- Nephropathy induced by cyclosporine
- Nephropathy induced by tacrolimus
- Neurological pain disorder
- Neurotoxicity caused by L-asparaginase
- Neurotoxicity caused by methotrexate
- Neurotoxicity caused by procarbazine
- Neurotoxicity caused by vinblastine
- Neurotoxicity caused by vincristine
- Nitrogen mustard derivative adverse reaction
- Nitrosurea adverse reaction
- Paclitaxel adverse reaction
- Palmar erythema
- Pancytopenia caused by immunosuppressant
- Pancytopenia caused by medication
- Pancytopenia caused by medication
- Pentostatin adverse reaction
- Peripheral neuropathic pain
- Peripheral neuropathy due to and following antineoplastic therapy
- Plicamycin adverse reaction
- Poisoning by L-asparaginase
- Post-immunosuppression viral warts
- Procarbazine adverse reaction
- Procarbazine poisoning
- Razoxane adverse reaction
- Retinoid adverse reaction
- Ruxolitinib withdrawal
- Secondary aplastic anemia
- Stomatitis due to cytotoxic therapy
- Stomatitis medicamentosa
- Stomatitis medicamentosa
- Terpenes adverse reaction
- Terpenes adverse reaction
- Therapy related acute myeloid leukemia due to and following administration of antineoplastic agent
- Therapy-related myelodysplastic syndrome
- Thioguanine adverse reaction
- Thiotepa adverse reaction
- Thrombophilia due to antineoplastic agent therapy
- Toxic cardiomyopathy
- Toxic dilated cardiomyopathy
- Treosulfan adverse reaction
- Triptorelin adverse reaction
- Ulcerative inflammation of oral mucous membrane due to and following administration of antineoplastic agent
- Ulcerative stomatitis
- Vinblastine adverse reaction
- Vinblastine poisoning
- Vinca alkaloid adverse reaction
- Vincristine adverse reaction
- Vincristine poisoning
- Vindesine adverse reaction
- Warts in immune-deficient state
Clinical Classification
Clinical Classifications group individual ICD-10-CM diagnosis codes into broader, clinically meaningful categories. These categories help simplify complex data by organizing related conditions under common clinical themes.
They are especially useful for data analysis, reporting, and clinical decision-making. Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance. Each category is assigned a unique CCSR code that represents a specific clinical concept, often tied to a body system or medical specialty.
Adverse effects of drugs and medicaments, initial encounter
CCSR Code: INJ028
Inpatient Default: X - Not applicable.
Outpatient Default: Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.
Clinical Information
Agranulocytosis
a decrease in the number of granulocytes; (basophils; eosinophils; and neutrophils).Feline Panleukopenia
a highly contagious dna virus infection of the cat family, characterized by fever, enteritis and bone marrow changes. it is also called feline ataxia, feline agranulocytosis, feline infectious enteritis, cat fever, cat plague, and show fever. it is caused by feline panleukopenia virus or the closely related mink enteritis virus or canine parvovirus.Agranulocytosis
a marked decrease in the number of mature granulocytes (most often neutrophils) in the peripheral blood.Chemotherapy Related Agranulocytosis|Chemotherapy-Related Agranulocytosis
agranulocytosis that occurs with chemotherapy.Congenital Neutropenia|congenital neutropenia|genetic infantile agranulocytosis|infantile genetic agranulocytosis
a rare congenital disorder characterized by mild or severe reduction of neutrophils in the peripheral blood and recurrent infantile infections.Cyclic Neutropenia|CH|CN|Cyclic Agranulocytosis|Cyclic Hematopoiesis|Cyclic Hematopoiesis|Dysplasia, Myelocytic Periodic|Periodic Neutropenia|cyclic neutropenia|periodic neutropenia
a hematologic disorder caused by a mutation in the elane (ela2) gene; clinical manifestations include recurrent neutropenia with resultant susceptibility to infection leading to fever.Tumor Protein 63|CUSP|Chronic Ulcerative Stomatitis Protein|Keratinocyte Transcription Factor KET|TP63|Transformation-Related Protein 63|Tumor Protein p73-Like|p40|p51|p63|p73L
tumor protein 63 (680 aa, ~77 kda) is encoded by the human tp63 gene. this protein plays a role in the mediation of both transcription and limb morphogenesis.Ulcerative Stomatitis
inflammation of the mouth mucosa associated with the presence of ulcers.
Coding Guidelines
When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (T45). Use the following options for the aplicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Replaced Code
This code was replaced in the 2025 ICD-10-CM code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2024. This code was replaced for the FY 2025 (October 1, 2024 - September 30, 2025).
- T45.AX5A - Advrs effect of immune chkpt inhibtr/immunostim drugs, init
Code Edits
The Medicare Code Editor (MCE) detects errors and inconsistencies in ICD-10-CM diagnosis coding that can affect Medicare claim validity. These Medicare code edits help medical coders and billing professionals determine when a diagnosis code is not appropriate as a principal diagnosis, does not meet coverage criteria. Use this list to verify whether a code is valid for Medicare billing and to avoid claim rejections or denials due to diagnosis coding issues.
Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.
Convert T45.1X5A to ICD-9-CM
Below are the ICD-9 codes that most closely match this ICD-10 code, based on the General Equivalence Mappings (GEMs). This ICD-10 to ICD-9 crosswalk tool is helpful for coders who need to reference legacy diagnosis codes for audits, historical claims, or approximate code comparisons.
Adv eff med/biol NEC/NOS
ICD-9-CM: 995.29
Approximate Flag - The approximate mapping means this ICD-10 code does not have an exact ICD-9 equivalent. The matched code is the closest available option, but it may not fully capture the original diagnosis or clinical intent.
Adv eff antineoplastic
ICD-9-CM: E933.1
Approximate Flag - The approximate mapping means this ICD-10 code does not have an exact ICD-9 equivalent. The matched code is the closest available option, but it may not fully capture the original diagnosis or clinical intent.
Table of Drugs and Chemicals
The parent code T45.1X5 of the current diagnosis code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.
According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.
Patient Education
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
What is a drug interaction?
A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:
- Two drugs, such as aspirin and blood thinners
- Drugs and food, such as statins and grapefruit
- Drugs and supplements, such as gingko and blood thinners
- Drugs and medical conditions, such as aspirin and peptic ulcers
Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.
What are side effects?
Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.
What are drug allergies?
Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.
How can I stay safe when taking medicines?
When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.
[Learn More in MedlinePlus]
Code History
- FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
- FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
- FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
- FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
- FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
- FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
- FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
- FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
- FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
