2026 ICD-10-CM Diagnosis Code Z40.81Encounter for prophylactic surgery for removal of ovary(s) for persons without known genetic/familial risk factors
Z40.81 is a billable ICD-10-CM diagnosis code for encounter for prophylactic surgery for removal of ovary(s) for persons without known genetic/familial risk factors. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 742 through 743, 760 through 761. The code is exempt from POA reporting.
Code Identity
Code Classification
Present on Admission (POA)Billing
Z40.81 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Encounter for prophylactic oophorectomy for persons without known genetic/ familial risk factors
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Admission (for) - See Also: Encounter (for);
- prophylactic (measure) - See Also: Encounter, prophylactic measures;
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Admission(for)
- prophylactic (measure)
- oophorectomy for persons without known genetic/ familial risk factors
- Admission(for)
- prophylactic (measure)
- organ removal
- ovary (s)
- for persons without known genetic/familial risk factors
Code History & ChangesHistory
New Code Z40.81 was added to the ICD-10-CM code set for FY 2026, effective October 1, 2025.
Replacement Z40.81 replaces the following previously assigned code(s):
- Z40.8 - Encounter for other prophylactic surgery
Questions About Z40.81Overview
Is Z40.81 (Encounter for other prophylactic surgery) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report encounter for prophylactic surgery for removal of ovary(s) for persons without known genetic/familial risk factors on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does Z40.81 group to?
When encounter for prophylactic surgery for removal of ovary(s) for persons without known genetic/familial risk factors is the principal diagnosis on an inpatient stay, it groups to MS-DRG 742, 743, 760, 761, with relative weights from 0.5696 to 1.8348 depending on complications. Higher weights mean higher Medicare reimbursement.
Is Z40.81 exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for encounter for prophylactic surgery for removal of ovary(s) for persons without known genetic/familial risk factors on inpatient claims.
